SNHG29
SNHG29 acts as a potential molecular biomarker to predict the prognosis in acute myeloid leukemia (AML) patients. This long non-coding RNA also has a role in the pathological process of rheumatoid arthritis (RA) [1]. However, further studies are required to know the underlying function.
Contents
Annotated Information
Name
SNHG29: Small nucleolar RNA host gene 29 (HGNC nomenclature). Synonym: LRRC75A-AS1 [2], C17orf76-AS1 [1].
Characteristics
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Function
SNHG29 is highly associated with the target genes of transcription factors tumor protein 53 and ETS variant 6 [2].
Regulation=== SNHG29 may regulate TP53 and ETV6 target genes in trans manner [2].
Diseases
Expression
SNHG29 expression is positively correlated with ATAD3A and NDUFA4L2 mRNA expression levels [1].
| Experiment | Forward primer | Reverse primer |
|---|---|---|
| Quantitative PCR | 5'-CACGTGAAAGGGGGAGAAA- 3' | 5'-CCAACAGCACAGAAGGCGT- 3' [1] |
Labs working on this lncRNA
- Department of Hematology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200092, P.R. China. [2]
- Department of Clinical Laboratory Science, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing, 210002 China. [1]
- Department of Osteology, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing, 210002 China. [1]
- State Key Laboratory of Analytical Chemistry for Life Science, Department of Chemistry, Nanjing University, Nanjing, 210093 China. [1]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Zhang Y, Xu YZ, Sun N, Liu JH, Chen FF, Guan XL, Li A, Wang F, Zhao QF, Wang HY, Song SS. Long noncoding RNA expression profile in fibroblast-like synoviocytes from patients with rheumatoid arthritis. Arthritis research & therapy. 2016, 18(1):227.
- ↑ 2.0 2.1 2.2 2.3 2.4 Wang F, Tian X, Zhou J, Wang G, Yu W, Li Z, Fan Z, Zhang W, Liang A. A three‑lncRNA signature for prognosis prediction of acute myeloid leukemia in patients. Molecular medicine reports. 2018, 18(2):1473-84.
Sequence
>gi|25144|ref|NR_027160.1| Homo sapiens Small nucleolar RNA host gene 29 (SNHG29), long non-coding RNA
000081 TCTCTAGGAA TCTGGGAGTA GTAGCTGGGG GGCAAGAGCA AATAAAGAGC TCGAGCTTCT GTGGTCTCTG GGGAGATGTT 000160
000161 CCCGGGAAGC CTGTCTAGAG GGCGGAGGGC AGCTGTTGAG ATGGCGTGGC TCCCCGGCTC CTGCGCCCGC GTGGCTTTCG 000240
000241 CGGCGGGCGC TGCGGCCCGG TATTGGACAG CCTGGCAGGG CAGCGCGGGG CCGAATCCGG CTGCCGTGGC TGAGGCTCAT 000320
000321 GGATCACTCT TTTGTGGTAG GGCCACATCT GCCAGAGCCT GGAGTCTGCG AAGGCCGGGA CCCGGTTCCC CGGCCCACAG 000400
000401 TGGGGGTGTG CAAACCCGAG AGAACTGGTC GCTGAAACCT CTACAACTTA GTTGACCGTA ACTGCCAGAG CCCTGCCCTG 000480
000481 AATTCCTGTC CTTACTCCCT CTTTAAGATT GCGTACCCAC TGCAGAGTGC TGAAGACGGG GTAGCCACGA GGTTGCAAAT 000560
000561 TCGTGAAGAA TCAGCATCAT GTTTGGCAGC TGAGTATTGG AGCCAGGAGC CTGCCATGAG GTTTTGAGAA CAGAGTGCTG 000640
000641 TTTTAGAGCT GGCAGCAGCA TCTCAGCCCA AGAGAAGGTT ATATTCCCAG AGGATGTCAG TCCCAAGGAC CAGTAGCTGC 000720
000721 CATCAGTTTG GATTCTGAAA ACTAACTGGC ATCAACACTG GGTGTAGAAA CATGCTTGCC TTATGTATCA GAGGACATGC 000800
000801 TCAGCAGATC CAAGAGATAT ATTTGGCAAC TTTTTCTAGA AAAGGCACAT TGGGTATCAT TCATTACATT CTTGAGTTTT 000880
000881 TTTGGGTTTT TTTTTTTTTT TTTGAGACAG TCTTGCTGTA TTGCCCAGGC TGGAGTGTGG TGGCACAATC ACAGCTCATT 000960
000961 GCATCCTCAA TCACCCAGGC CTAAGCAATC CTCCCACCTT GTAGCTGGGA CTACAGCTCA CAGCACACCT GGCTAAAATT 001040
001041 TTTTTTTTGT TGAGACGGAT TCTCTATGTT GCCCAGGCTG GTCTCAGGCT CCTGGGCTCA GATGGTCCTC CTGCCTCAGC 001120
001121 TTCCAAAGGC ACAGGCCAAG TTGTAGCTTT GTCCCTTGCC ATCATGCCCA ACAAGAGGTT CTATACCTTT TAATGAATTG 001200
001201 ACTTTCATAA ATTGGTTATG TTGGTGGGCA AAGTTCTTTA AGCTGGAAAT TGTAAATTCC TCCTGAAATG TTTTTTCATG 001280
001281 CAGTTACCAT GAACTAATAC TACAATAAAG GATGGTCTTG GGTGTCAATT CTTGAAAA
