MIR205HG
MIR205HG act as a executor of the pro-oncogenic functions of mutant p53.
Contents
Annotated Information
Name
MIR205HG: MIR205 host gene [1] LINC00510 (HGNC).
Characteristics
MIR205HG is an intergenic 940 bp long non-coding RNA, located on human chromosome chr1q32.2, consisting four exons (GenBank) [1].
Function
MIR205HG is involved in colony formation and migration of HNSCC cells and is required for pro-tumorigenic activities of the mutant p53 protein[1]. Down-regulation of MIR205HG expression significantly reduced cell proliferation, cell migration and clonogenic activity of head and neck cancer cells. Expression of MIR205HG was significantly increased in HNSCC with mutated TP53 when compared with matched non-tumoral tissues. Furthermore, MIR205HG expression levels were significantly higher in tumoral samples with mutant p53 than in tumoral tissues expressing wild-type p53 [1]..
MIR205HG depletes endogenous miR-590-3p leading to elevated levels of ccnb and cdk1 in HNSCCs carrying mutated TP53, thereby leading to increased cell proliferation in head & neck squamous cell carcinoma (HNSCC) [1].
Expression
MIR205HG is overexpressed in tumor samples from TCGA and also in a cohort of HNSCC patients [1].
Regulation
MIR205HG is regulated by p53 through binding to regulatory elements located in the upstream region of the first exon of MIR205HG [1].
Diseases
- Head & neck squamous cell carcinoma (HNSCC) [1]
Labs working on this lncRNA
- Oncogenomic and Epigenetic Unit, Department of Diagnostic Research and Technological Innovation, IRCCS Regina Elena National Cancer Institute, Rome 00144, Italy [1]
- SAFU Unit, Department of Diagnostic Research and Technological Innovation, IRCCS Regina Elena National Cancer Institute, Rome 00144, Italy.[1]
- Molecular Chemoprevention Group, Department of Diagnostic Research and Technological Innovation, IRCCS Regina Elena National Cancer Institute, Rome 00144, Italy.[1]
- Dofasco Chair Cancer Experimental Therapeutics, Department of Oncology, Faculty of Health Science, McMaster University, Hamilton, Canada.[1]
References
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 Di Agostino S, Valenti F, Sacconi A, Fontemaggi G, Pallocca M, Pulito C et al. Long Non-coding MIR205HG Depletes Hsa-miR-590-3p Leading to Unrestrained Proliferation in Head and Neck Squamous Cell Carcinoma[J]. Theranostics. 2018, 8(7):1850-1868.
Sequence
>gi|642587|ref|NR_145435.1| Homo sapiens MIR205 host gene (MIR205HG), long non-coding RNA
000081 ATTCTAAAAA TTCAGCTCAA TTCTCAACCA TACTCCAAAC TCTCTCTTTT CCAGCTACCT TTACTCCCTC TCCTTCAATT 000160
000161 CCACTTTCCT CTGCTTACTT TTTTTTTTTT TCTGACAGGG TCTCACTTTG TCGCCCGGGC AGGAGTGCAG TGGCTCAATC 000240
000241 TTGGGCTCAC TGCAGCCTCA ACCTCCCAGA GGCGGGGTTT CACCATGTTG CCCAGACTGG TCTTGAACTC CTGAGCTTAA 000320
000321 GCAATCCACC TGCCTCGGCC TCCCAAAGTG TTGGGATCAC AGGCGTGAGC CACCGCATCC GGCCTCATGT TCTTTTTCAT 000400
000401 TAAAGAGAGA AATCAACTAT TCAGGACCGG CCCCCACCTT TCCTCAGGAG TCATTTCTGT TCCGCACAGG CCTGCTGAAC 000480
000481 TGGGTGCTTT ATATAGGAAA GGACCAACCA CACCGAGCTC AGTTATGGCA CACACAGTGG GACCTAGACA AAGGGAGAGG 000560
000561 GTGACCGACA TCCCAACTAG ATTTCAGTGG AGTGAAGTTC AGGAGGCATG GAGCTGACAA CCATGAGGCC TCGGCAGCCA 000640
000641 CCGCCACCAC CGCCGCCGCC ACCACCGTAG CAGCAGCAGC AGCAGCAGCA GCAGCAGCAG CAGCAGCAAG AGTAACTCTG 000720
000721 ACTTAGGAAT AGAGACAGCC AGAGAGAAAT GTGATCAATG AAGGAGACAT CTGGAGTGTG CGTGCTTCTT CAGAGGGACG 000800
000801 GGTGATGGGC AGATTGGAAA AAGCACCGCA GATGGGAACC TTAATCTTTC TTTTCTAAAA TTGATGCTAT GAAAATTTGC 000880
000881 GTTTTCTGTA ACTTGTAAAA ACTAAAAGTT GCTTGTCTAC TGAAAAAAAA AAAAAAAAAA
