SCAT8

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SCAT8, is a long non-coding RNA that modulate cell cycle progression and cell proliferation.

Annotated Information

Name

SCAT8: S-phase cancer associated transcript 8 [1], EYS-AS1 (HGNC nomenclature).

Characteristics

SCAT8 is 1454 bp long non-coding RNA, located on human chromosome chr6q12 (HGNC) [1].

Function

The top clinically relevant SCATs regulate crucial cancer cell hallmarks. MTT proliferation assay of Caki-2 (KIRC) cell line depleted with two independent LNAs (SCAT4, SCAT8) or siRNAs (SCAT7) (left graph). Cell cycle profiles of Caki-2 cells depleted with two different LNAs or siRNAs (middle grapgh). g Estimation of the caspase 3/7 activities 48 h post-silencing of the corresponding SCAT in Caki-2 cells (right grapgh).[1]

Higher expression of all SCATs is correlated with poor overall survival [1].

Depletion of SCAT8 in Caki-2 cells altered cell proliferation, inhibited cell cycle progression, and induced apoptosis. SCAT8 appeared to be the top prognostic indicator with the higher hazard ratio in multivariate models and it also interferes with cancer cell hallmarks, indicating that it may be an oncogenic driver in multiple cancers [1].

Expression

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Regulation

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Diseases

  • kidney clear cell carcinoma [1]

Labs working on this lncRNA

  • Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, 40530 Sweden.[1]
  • Department of Pediatrics, Institution for Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, 40530 Sweden.[1]

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Ali MM, Akhade VS, Kosalai ST, Subhash S, Statello L, Meryet-Figuiere M et al. PAN-cancer analysis of S-phase enriched lncRNAs identifies oncogenic drivers and biomarkers[J]. Nat Commun. 2018, 9(1):883.

Sequence

>gi|112935969|ref|NR_157848.1| Homo sapiens S-phase cancer associated transcript 8 (SCAT8), long non-coding RNA

000001 TAGGAAAGTC AAGAAATAGG AAGGAAATCG GTCAGTTTTC TATCATCATT GGTTGGGCTT GAAAGTGTAA CAAGAGGTTA 000080
000081 AAATAGAAGT TCTAGCTGAA GCACAAAGAA AGTAGAAACA ACACATCAAA GTGAGGGATT TATAAAGCAG GAGACTGAAA 000160
000161 ACCAGCTGGT GACTCTTGAA TTCCTCACCC TTATTGAGAG TATAAAAGGC TTATAGCCCT CACCCTTTCA CCTCAAATCA 000240
000241 AGAGGGAAGG GTTTTAGAAA CACAACTTGG AGAGCTTAAT ATGTATCCCT GAAGTTTGAG GAAAGGGGAC GTAGTGTACT 000320
000321 GACTTCTGCC TGGAAAGTCT AACAGGTGGG AGATTAATTG ACTGCAATGA AGGAGAAAGC CAATGACAGG TTGCTTCTTG 000400
000401 ACTGGAATTG TTCAGCACTC CAGAGGCTGT CAGGGAAAGG ATGTGAGCAT GCTGCCTGGA ATCTGATGTG GCTCAGCTGT 000480
000481 AGGACAAAGA TAGTGTGTTT TCTTAAGTTC TGACCAAATG AACCACCTTA AGAGACAAAG ATCACTCAGC AAGGAAAGCT 000560
000561 GAAGATGCTA TGAGATGCCA GAGGTTGGGG AAGGAGCAAA CAACCAGCTG GAATGGATAT GCCTTTTCTC AAAGAAAATT 000640
000641 GCAAGTGGAA GAATTCCAGC CATGGGGTCT CCAAAGCATC CGTGAAACTG TTCCACAAGA CAAGGATGGA TGACTGAATG 000720
000721 CCAAACCCAG AGAGCAGTGA AGCTAAATCA ACTCAATCAT TTCAGTGAAG AAAGAAATCT CCTGTCCTTT CCTGTCCCTG 000800
000801 AACTCCATGA TGAAGGGCCA TGTGCTGTAG GTAGCAAAAC AGGGGAGAAA GAATTTCAGT TTTCCTTTTC CCTTGAAATT 000880
000881 TTCTAGCTAA ATCAGTCCGA AATGTGGAAG GAAAAAGCAT GAAGTTTTTT ATTTTTATTT TTTGAGACTG AGTCTTGCTC 000960
000961 TGTTGCCCAG GCTGGAGTGC AGTGGTGTGG TCTTGGCTCA CTGCAACCTC CTCTTCTCGA GTTCAAATGA TTCTCCTGCC 001040
001041 TCTGCCTCCC GAGTAGCTGG AATTACAGCC GTGCACCACC ATGCCCAGCT AATTTTTATA TTTTTAGTAG AAACAGGTTT 001120
001121 CACCATGTTG GCCAGGCTGG TAATGAACTC CTGACTTCAG GTGTCTGCCA GCCTTGGCCT CCCAAAGTGC TGGAATTACA 001200
001201 GGCATGAGCC ACCACACCTG GCCACATGAA AGCATGAAAT TTAATGCAGA TAGATTTACC TATCATATAA AAATGGAAAA 001280
001281 CCGAATTACT AAGTGGAACT GATATTTTGT GATCCAGGAA TGACCATGTC TGAACTTTCA TTTGAGGGGA AAAAGGATAA 001360
001361 TTAACACCAT TGAACAAATT TAAAGGGAGA ATGGAAGACA AAGTAAAGTT GTTTTATGTT TACATACAGC TGTGCTATTA 001440
001441 AGAAAAGCTA CCGA
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