LGALSL-DT
LGALSL-DT, LGALSL divergent transcript aberrantly expressed in postmenopausal osteoporosis (PMOP).
Contents
Annotated Information
Name
LGALSL-DT: LGALSL divergent transcript (HGNC:53951)
Alias
LOC105374771 (HGNC:53951)
Characteristics
LGALSL-DT is a long non-protein coding RNA gene located at chromosome position 2p14. [1]
Function
LOC105374771 may be involved in the pathogenesis of PMOP by regulating the expression of its nearby and co-expressed differentially expressed mRNAs and the pathway of osteoclast differentiation. LOC105374771 also regulates the expression of LGALSL. [1]
Regulation
LOC105374771 was the most markedly downregulated lncRNA in PMOP. [1]
Expression
This lncRNA was co-expressed with 130 differentially expressed mRNAs (DEmRNAs), including ALPL, SOCS3, ADM, CD177 and SLPI. LOC105374771 may affect the pathogenesis of PMOP by regulating the expression of these DEmRNAs. [1]
Disease
Postmenopausal osteoporosis (PMOP) [1]
Labs working on this lncRNA
Department of Orthopedics, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China
References
Sequence
>ENST00000441630.1, Homo sapiens lncRNA LGALSL-DT cDNA antisense
000081 AAAGAACGAA GCAGAGAGGA CTCAAGACAC TGCATTTGGG AGCCACCTCT GCTTCCAGAA CACTTGTCTC TTCCAAGAGC 000160
000161 TGGATTCAGT ATCAAAAGGA GAAGGTATGA CATAGCTCCA CCTACATGCA AGGGGAGCCA GGAAGTGCAA TCCCTGGCTG 000240
000241 GGCTGCCACG TCTCAGAAAC CATTAAGCCT ATGGAAGGTC TCTGGATTTG ATGGCAAATG GCAGCAGAAA TGTGGAAAAG 000320
000321 ATCAAAGTGA TGTCAAGGTT GATCTCTGAG TTTGGCATGG CTGAACTCAA ACATCATTTG CCATGGACCC ACAGTGTCTT 000400
000401 CAGTAGCTGA GTGTGGTGTC ATTCCCCTAT GATATGTGCA CTCAATTGCT GGCCAGTTTT TGTTTTTTGT TTTTGAGAGA 000480
000481 GTCTCGCTTT GTCTCCTAGG CTGGAGTGCA GTGGCACGAT CTCGGCTCAC TGCAACCTCC GCCTCCCGGG TTCAAGTGAT 000560
000561 TTTCCTGCCT CAGCCTCCCG AGTAGCTGAG ATTACAGGCA TGTGCCAGCA GGCCCGGCTA ATTTTTTTTG TAATTTTAGT 000640
000641 AGAGACGGGG TTTTGCCATG TTGGCCAGGC TGGTCTCGAG CTCCTGGCCT CAAGTGATCC ACCTGCCTCC ACCTCCCAAA 000720
000721 GTG
