DLEU2L
Contents
Annotated Information
Name
Approved symbol: DLEU2L
Approved name: deleted in lymphocytic leukemia 2 like
HGNC ID: HGNC:13225
Previous names: BCMS upstream neighbor-like
Alias symbols: BCMSUNL
RefSeq ID: NR_002771
Characteristics
BCMSUNL located at 1p22-p31, not part of the critical deletion region of 1p22 in MCLs. BCMSUNL has intronless, lacks exon 2 and shows 90.3% homology on the nucleic acid levelcompare with BCMSUN.
Expression
The highly expressed in primary mouse hepatocytes treated with GW3965((Sallam T 2016)) and upregulated in OS(Osteosarcoma) tissues((Wang G 2017)).
Regulation
Please input evolution information here.
Function
LeXis binds with heterogeneous ribonucleoprotein Raly which contains both an RNA-binding domain and a leucine-zipper coiled domain, to affect the expression of srebf2 gene, resulting to the change of the level of SREBP-2(sterol regulatory element-binding protein), to modulate cholesterol metabolism((Sallam T 2016)).
LeXis positively regulates CTNNB1 expression by functioning as a ceRNA against miR-199a to promote osteosarcoma growth((Wang G 2017)).
Disease
- osteosarcoma
- colon adenocarcinoma [1]
Evolution
Please input evolution information here.
Labs working on this lncRNA
- No.4 Department of Orthopedics, Cangzhou Central HospitalCangzhou, Hebei Province, China
- Department of Pathology and Laboratory Medicine, Howard Hughes Medical Institute, University of California, Los Angeles, California 90095, USA.
References
- ↑ Shahriyari L. Effect of normalization methods on the performance of supervised learning algorithms applied to HTSeq-FPKM-UQ data sets: 7SK RNA expression as a predictor of survival in patients with colon adenocarcinoma. Brief Bioinform. 2017 Nov 3. doi: 10.1093/bib/bbx153.
