ENST00000531381.1
MIR100HG, the human miR-99a/100 ~ 125b cluster host gene, locating in the nuclear cell compartment, plays a role in the regulation of erythro-megakaryocytic development.
Contents
Annotated Information
Name
Approved symbol: MIR100HG
Approved name: mir-100-let-7a-2-mir-125b-1 cluster host gene
HGNC ID: HGNC:39522
Previous names: mir-100-let-7a-2 cluster host gene (non-protein coding); mir-100-let-7a-2 cluster host gene;
Alias symbols: AGD1; lncRNA-N2; linc-NeD125
Alias names: "adipogenesis down-regulated transcript 1", AGD1, "lncRNA neuronal 2", lncRNA-N2[1]
RefSeq ID: NR_024430
LncBook ID: HSALNT0289173
Characteristics
MIR100HG was localized in the nucleus and their expression correlated with the corresponding miRNA clusters[1].
It was contained in BH3-like motif ,which was associated with the single nucleotide polymorphism (SNP) rs577948, a susceptibility locus for high myopia in Japanese subjects[2].
Cellular Localization
MIR100HG was localized in the nucleus[1].
Regulation
TGF-β increases MIR100HG transcription through SMAD2/3 TFs[3].
Function
Knockdown of MIR100HG impaired cell viability and replating-efficiency of AMKL（acute megakaryoblastic leukemia） cells,which implys MIR100HG may contributes to the maintenance of leukemic growth[1].
Diseases
- myeloid leukemia
- Pancreatic ductal adenocarcinoma (PDAC)[3]
Labs working on this lncRNA
- Pediatric Hematology and Oncology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany[1]
- School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China[2]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Emmrich S, Streltsov A, Schmidt F, Thangapandi VR, Reinhardt D, Klusmann JH. LincRNAs MONC and MIR100HG act as oncogenes in acute megakaryoblastic leukemia[J]. Molecular cancer. 2014,13:171.
- ↑ 2.0 2.1 Zhao F, Bai J, Chen W, Xue A, Li C, Yan Z, et al. Evaluation of BLID and LOC399959 as candidate genes for high myopia in the Chinese Han population[J]. Molecular vision. 2010,16:1920-7.
- ↑ 3.0 3.1 Ottaviani S, Stebbing J, Frampton AE, et al. TGF-beta induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression[J]. Nat Commun, 2018, 9: 1845.
Basic Information
| Transcript ID |
ENST00000531381.1 |
| Source |
Gencode19 |
| Same with |
lnc-BLID-1:4,NONHSAT024776,MIR100HG,AGD1, lncRNA-N2 |
| Classification |
intergenic |
| Length |
3370 nt |
| Genomic location |
chr11-:121959811..121972886 |
| Exon number |
2 |
| Exons |
121959811..121962448,121972155..121972886 |
| Genome context |
|
| Sequence |
000001 GAGACACACT ACAACAGGAG AGGGAGCAAG CGCGAGAGGA TATTAGAAGA GAGGCTTGTC TCCAAGATAT GGAAGGAAGT 000080
000081 GAGAAATGAC AGGGCTGCAA GCTTTGTATG TAGGAGCCCG GCAGGGCGGG GGAGCGGCGA GGAGAGCCAA GTGGATTCTC 000160 000161 AGAAAAGGGG GGAAGCCATC GAAGAGCTAA AGGTGATTAG AGGGGGATAT TGATTTCTTA TTCTGCCAGA GATTTAAGCA 000240 000241 GGCATGCGAG GAATCTGCAC CATGGTTGGC AAAAAGAGAC CCGTTGCCTC CTGTAACCAG ACACTCAGGC TTTCCAGGAG 000320 000321 CCCAGGGAGC AAGCCGAGAA GAAAGGGGGC AGTGTGGTCT AGGAAAATTC AACTTGTCGC TGATTTGTGC CTGATGCCTG 000400 000401 CTGTCCGTCA GCAGCCTCCC TTACAATCTT TTTTTCTCTC TCTCCTTTTT TTTTCCTTGC CTTCTCCTTC TTCACTGAAG 000480 000481 CCTAGGGGAG CCAGTAAAGA TTAAATGTGC TTCTCAAAGG CAGCCACTTC ATGCTGCTAT GTCGAAAGGG CCATTATTAT 000560 000561 TATTATATTT TAATGGTAAA AGAGAAAAGG AGAGAGGTTG AGCGAGCGAG AGAGAAGCTA GGTGTGATGA TGACAGACTA 000640 000641 GCTTTTCTGA GAGGAAAAGG AAAAGGGAAG GGAGAGAAAA AGGAGAGCCT CTGAGCTCAA CGGAGGATTG TGCCTGAGAA 000720 000721 GAACCCACAG AGTTGTGTTG ATGTTCCTTT CAGCTGGTCC TATAGTACCC CTCCTCAGGA ATGTCTCCCC AGTGCAAGGA 000800 000801 CAAAGACTGA AGAGACTGCT ATATTGATGG ACTCTCAAGC CAACTATGAA GTTGAAACAA AGAAAGTGAT CACCTGAAGA 000880 000881 CACCTCCTCT GCTAAGAAAC ACCCCCAAAT TGTGCAGCTT CTGCCACTAG AACTCTCAGA ACAAGAGACA ATCTTTTCAA 000960 000961 GAAACAGAAA AACTCAATAA TGACATCTAG ATTTTCATGA GCCAAGAACT TTCCCTTCCT CATGTGTATT CCTCTGTTTG 001040 001041 TACTTAAATT CATGTGACAT TCATTTTTTT CCTAGTATGG ATATGCTTAT TAATGCACTT GTTTCAAAAT CCCAAATTGC 001120 001121 ACAAATGTGT TAATATTTTA AGAAACAAAA TGAATCCTAC AAGGAGAATG ATTTTTAGCC ACACATAGGG TTGGATCTTG 001200 001201 AGAGTGACCT ACAGAATAAA AGTACTTTTA AAATAAAGTA GTCAGAGGCT ATTCAAAGGG TAAAATAATC ATAGTACCAC 001280 001281 ATTGGTCCAC TTGACACTAA CCAATCGATC ATTTTTTTTT AATCAAGAAA GCTAGATTCT ATCAGATAAA ATCACTGCTT 001360 001361 CTAAAGAGTT TAAATCTAGT TAGAAAAAGT TATAGAAATG TTTGCAAAGA TAAGTAACAG ATAGAGTCAG TAGAGGATAA 001440 001441 GATCAAAAAC AAAACCAAGC AAAAGATGAG TTCAGGGGAG TTTGCCATCA AGTTGGCAAA ACTGACTTAC TTAGGGAAGA 001520 001521 AAGTTATAAA ACAGGAAAAT ATGAGATGAA CCTTGAGTGA TGTGGAAGAT TTAGATAAAT GGAAAGGAAG GAGAAAATGG 001600 001601 AGTTCTTTAG GTGGTTGTAA TTGGAGGAGG AAATGAATAC ACACATCTTG TTGACTTAAA CCCAGACATT CAGCAGCTCT 001680 001681 CTATACATAT CTGGAAAAGA CTGCACAGTC ACCTCCTGTC TCTCACCCCA GGTATTACTT AGAATTATTA TCATATTTCC 001760 001761 CTTCCTTTAA AGTAAGTAAG GGTGATTGGT GACAATATGG AGAACTATGA TTTTTCCATT AACCTAATAA TAATTGGTAT 001840 001841 TTATTGAGTT CTGTTAAGCA TTTTACATAT TAACTCACTT AAGCCTTTCA ACAGCCTTGC AAAATAGGTA TTATTATCCC 001920 001921 CATTTTACAG GCAAGAAAAC TGAGGTTTAA GTAACTTGCC GAAGTGCCAT ATACAGGGCT CACATTCAGT ATTGCAGTTG 002000 002001 CAAAGCTCAT GATCTATAGT GCCAAGTTGC AATATTGTAG TCAATGTCAC AATTATTACC CCTTTTTATA TTCCTTGATA 002080 002081 TTTTTCCATG GCAAACAATT AGCTATTTCA TTTAATAATC ACCTAAAACT TTTCAGTCTT CTGATTAAAA TTACGCTGGA 002160 002161 GTGATAGAAT GTATTTTCAT GATAGAAATT GGGAAAAAAA ATGGGGAATG AAGTTTATCA GCATTTCAGA CTTGTTTTTT 002240 002241 TTTTTTTTTT TTGCAAGACT TTGATGAGAT TGTTCACTTT TGTCTATGTA AAATCCCAAA TCCTTGAGAA TAAAAAAGGG 002320 002321 GGAGGTTTAA GTCACTTGTT GCAATGCCCT TTTTAATAGA GGCAATAAAT CTAAAGGCCA TAAATTTAGA GTGACTTACA 002400 002401 GAAGATCGAA CTTTGGAGTG TGGCAGAGTA AGGGATGGAA ACCGGGCCCT CCAGTTCACT ATCAGTAGCT TTTGCACTGG 002480 002481 TCTGCCCTTC CTAAATTAAG TATGCACTTC AATTTGATGA GTGGAAACAG TCTATCTGGG CAGTAACCAG GGAGCTTTGT 002560 002561 GCCTAGTAGA TTGCTTCTGT TCTGCACTTC TTTGGTTTCC CACCTCAATG TAAAAAATAG CTAGCAATGA AGTCCAGAAG 002640 002641 TTGTCAATGG TTCATCCCCA GAAGAATGCA TAATGTCCAA AGTTGTATGT GTATGATGTC TTCAATGGTA TTAAGTTATT 002720 002721 TCAAATTCTT AGTTCACCTA CATAAATCAT TTCTAACAAG CATCTTCTTA ACCAACTTTA TGCACAGTGT ATGTTTGTAA 002800 002801 GTGCTTCTGC ACGAATGTTT ATACATGACT GTTTCCATAG TACTTATGTT TTTAAAAATA TTCAGTCATT TCCTACTATA 002880 002881 ATCCTCATGT ATCCATGTAA CTGACTCAAA AATACTTCAG CCACAGAAAG CTAAAACTGA GCAAATCTCA TTCTTCTTTT 002960 002961 CCATCCCCTT TGCATGTGGC TGGCATTTAG TAATGATTAA TAATATGGCC AGCTGAATAA CAGAGGTTTG AGACACAATT 003040 003041 CTTTCTCAAA GGAGTCAGCT AAGCTGGGTC TACTTATGGA CAAACATCTA AATGTGTGGA AGTATCTGAT ATTTGACAAT 003120 003121 GGTAAATTTC CACTTAGCTA GCTAGCATTG TCAGACTTCA ATCTCCTCAT GGCTCTGGCC GTCCTGTTTT AAGCATGATA 003200 003201 ATTGTTGGCC ACATCTCACA TAGTTCTCAT TGAGTGAGTT CATAAATAAA CAGGGTTTTT TTTTTTTTTT AAAGAGCAGC 003280 003281 CAAGCACAAA GTGTGACTTT GTTGACATTT TATGTGACTT TGTCATATGT TCCTAACCCC CAATAAAAGC AATGTTGCAT 003360 003361 CAACTGTGAA |
Predicted Small Protein
| Name | ENST00000531381.1_smProtein_530:640 |
| Length | 37 |
| Molecular weight | 4510.4008 |
| Aromaticity | 0.111111111111 |
| Instability index | 55.4111111111 |
| Isoelectric point | 9.57720947266 |
| Runs | 6 |
| Runs residual | 0.0137917637918 |
| Runs probability | 0.0272625566743 |
| Amino acid sequence | MLLCRKGHYYYYILMVKEKRREVERAREKLGVMMTD |
| Secondary structure | LEEEELLLEEEEEEEEHHHHHHHHHHHHHHLLLLLL |
| PRMN | - |
| PiMo | - |
