SNHG14

Annotated Information

Name

Approved symbol: SNHG14

Approved name: small nucleolar RNA host gene 14

HGNC ID: HGNC:37462

Previous names: UBE3A antisense RNA 1 (non-protein coding); small nucleolar RNA host gene 14 (non-protein coding)

Previous symbols: UBE3A-AS1

Alias symbols: NCRNA00214; UBE3A-AS; UBE3A-ATS

Alias names: non-protein coding RNA 214; UBE3A antisense

RefSeq ID: NR_146177

LncBook ID: HSALNT0217643

Characteristics

Human UBE3A-ATS is a large (∼460 kb) transcript that initiates in the PWS-IC and extends distally through SNURF/SNRPN, IPW and overlaps UBE3A, alternatively spliced and serves as a host for several types of small nucleolar RNA (snoRNA) of the box C/D class that are contained within the introns and are expressed upon processing of the paternal copy of the host transcript.

Regulation

In the 7SK ribonucleoprotein, Larp7 binds directly to 3′ terminus of 7SK RNA ((Krueger 2008)) ((Markert 2008)), and prevents degradation of 7SK in vivo ((Krueger 2008)).

Function

Model of hLarp7 recognition of the 7SK 3′end and mechanism of assembly of core 7SK RNP((Eichhorn 2018))

The mechanism of epigenetic silencing of UBE3A has been associated with a brain specific paternal antisense (UBE3A-ATS) transcript in human and mouse.

Disease

Angelman syndrome (AS)

Evolution

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Labs working on this lncRNA

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References

Annotation originally sourced from lncRNAdb.