ACTA2-AS1

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Annotated Information

Name

Approved Symbol:ACTA2-AS1

Approved Name:ACTA2 antisense RNA 1

Synonyms:uc001kfo.1, ZXF1

Ensembl ID:ENSG00000180139

RefSeq ID:NR_125373

Chromosome

10q23.31

Function

UC001kfo promotes HCC proliferation and metastasis by targeting α-SMA.[1] UC001kfo potentially serves as a prognostic marker and a therapeutic target for treatment of HCC (hepatocellular carcinoma).[1]

Expression

Compared with tumor-adjacent tisses and cell lines, the expression of UC001kfo was upregulated in HCC.[1]

Sequence

>gi|667478416|ref|NR_125373.1| Homo sapiens ACTA2 antisense RNA 1 (ACTA2-AS1), long non-coding RNA

000001 GTGCTTAGGC ACTGCAGTTG AGTGGCTCAC AAGGAGCTAA AATTTCACTA ATGCGTATTC AGTGGGTGGT TCTGGTTTGC 000080
000081 CTGATTTTTG CCTCTGGGCA TGGCTGTTTC AGCCTGAGAG GCTGTTCCAA GAATGTTGCT TTACTAGGAG CTCATGCCGC 000160
000161 CTGGTGGTAA ATATGAAGTA CAGCAGTGCA ACAGACCAGT TTTACTCCAA GGAAACCCTG TAGAGATGAC AGCAATGGTT 000240
000241 GGTGATTTCT GCCTCAATTA TGAAAGTGAT CTGGTGTTAC AGGGCCAGAG AAGACTAGGG GAGTTCGGGT TTTCTAGACC 000320
000321 AAACAGACAC TCAGTCCTGG GCCTGGAGGT CTCTGCAGTG AGGTGCTGCC ACAGACAGAG CCACCTTAAC TCCTCAGGAC 000400
000401 AACCAGTGGC TTCCGACACA CACTATGCAC TGGAGGGCAA GCAGCTCTCA GCTTGGGAGC AACTGAGGAT GGTGAACAGC 000480
000481 CTGGGCAAGG AGTGCTCTGA GGCTAAGACC CTGAACAGCA GGAACCGAAG TGCAGCTCCC CACTTCAGGT AATGTGATTC 000560
000561 TACCCTTTGC CTGAGAAACA TATCCATCCT AATTGCCATG TGCTCAGCTG GACCACTAGA GGGAGCCATC CTGTAACGGG 000640
000641 TGAGGTCAAC CTAACAAATG GTATCAGTCG AGTATTGATC GGAGGCCAAC GCAAGAAGTT ACCAGTAGCC TATTTCAGAT 000720
000721 TTATTAAAAA ACACATAGGT AACGAGTCAG AGCTTTGGCT AGGAATGATT TGGAAAAGAA CTGAAGGCAT AATTCCACAG 000800
000801 GACATTCACA GTTGTGTGCT AGAGACAGAG AGGAGCAGGA AAGTGTTTTA GAAGCATTTG CGGTGGACAA TGGAAGGCCC 000880
000881 GGCTTCATCG TATTCCTGTT TGCTGATCCA CATCTGCTGG AAGGTGGACA GAGAGGCCAG GATGGAGCCA CCGATCCAGA 000960
000961 CAGAGTATTT GCGCTCCGGA GGGGCAATGA TCTGTCAGTC AAGATGAAAA AGAATGGTCA TTAATGTCAT CATTAGTGCA 001040
001041 GTCGTTAGTG CGGTAGGACA GAGCCTGGAT GTTCTACCAT GGCCTAGTTT CTTGTTCAGC AGGGACACAG GCTTGTCTGT 001120
001121 TAGATGCCAA TTGTGTCCTA ATTGTGTCAT GTTCTTGGCA GGACCGCCAG AGGGAGCCAT GGATTTAGAA ATTCTTCAGT 001200
001201 GGTTTCATGG ATGCCAGCAG ACTCCATCCC TGGAAAAGAG ACACAGGCCA TGGTCCTTAA GTGGAGAGTA AAACCCAGGC 001280
001281 TAGACATGGA AGACCAGACT TGAACATCTG GATGATCTTG CAGTGGACTG AGGCTGGGAA GACATAATAA TCTAGGAACC 001360
001361 ACCTGTCTGA GAGACAAAAG GGTCTTGTTA TGCTCTATGT CTTCCTGCCT GCCTTCTAAT GAGGAAGGCC TGCTGCAGCA 001440
001441 TCCTGAGGTG TGGGCTACAA CAGAAATGCT TTTGGTCTTG GGGCAACCGT CACTTGTCTC CATGTTCTGG AGGCTGGCTT 001520
001521 GATATGGAAG AAGACAATGA CTCCCCTTCC CAGGAAAAGG GCGTTTGTTG CCTACCGATG AAGGATGGCT GGAACAGGGT 001600
001601 CTCTGGGCAG CGGAAACGTT CATTTCCGAT GGTGATCACT TGCCCATCAG GCAACTCGTA ACTCTTCTCA AGGGAGGATG 001680
001681 AGGATGCGGC AGTGGCCATC TCATTTTCAA AGTCCAGAGC TACATAACAC AGTTTCTCCT TGATGTCCCG GACAATCTCA 001760
001761 CGCTCAGCTG TCAACCAGAT ACAAACATTG TGGCAAACAT TAGGGTCTGC ACAGGTGGCA AAGATTCACC TGCCCTACTG 001840
001841 CAGTCTCTCC CTCAAGACAT GTGCCATCAA AAAATGTGTC AGTTCAATAT TCTGCAATCC AAAATCCACA ATGATAATGA 001920
001921 CGTAGTAGGG CCACCAGGGA ACCACCTCTG TTCCTAGGAC AGTGTCTCAT GCATAGTAGG CCCTCAGCAT GCATTGTCTG 002000
002001 GGAAATGCAT AACAAGAATA AAATGAGCTA GCTAGAGAAA GGC

Labs working on this lncRNA

  • Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China. Electronic address: pyfzzuni@163.com

References

  1. 1.0 1.1 1.2 Pan Y, Qin T, Yin S, Zhang X, Gao X, Mu L. Long non-coding RNA UC001kfo promotes hepatocellular carcinoma proliferation and metastasis by targeting α-SMA. Biomed Pharmacother. 2017 Mar;87:669-677. doi: 10.1016/j.biopha.2017.01.018. Epub 2017 Jan 12. PubMed PMID: 28088733.