DEC1
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DEC1, a candidate tumor suppressor in 9q32
Contents
Annotated Information
Name
Approved symbol: DEC1
Approved name: deleted in esophageal cancer 1
HGNC ID: HGNC: 23658
Aliases: CTS9, Candidate Tumor Suppressor CTS9
RefSeq ID: NR_163556
Characteristics
Function
DEC1 cDNA can suppress growth of some cancer cells in vitro, it is a candidate tumor suppressor in 9q32 [1].
Regulation
Disease
Expression
The DEC1 gene is expressed in most normal human tissues, including the esophagus, but its expression is lower than normal, often absent, in more than half of the esophageal carcinomas examined [1].
Sequence
>PREDICTED: Homo sapiens deleted in esophageal cancer 1 (DEC1), transcript variant X1
000001 CTTCCAGTTC TGGAGGCTGG GAAGTGGAAG AGCATTGTGC CAGCACCTGG TGAGGGCCTT CTTGCCGTGT TACACATGAT 000080
000081 GGTTTTTACT GATGCCCTGC ACAGAGAGAG GTCTGTAAAG TGGCAAGCAG GAGTCTGCTA CAATGGAGGA AAGGATTTTG 000160
000161 CTGTATCTCT TGCCAGGCCC AAGGCTGCAG AGGGAATTGG TAATATACTT CATTTAATAA TAGTGTTTTA AGGGACATTA 000240
000241 TCATTTCATC CTATGTGGTA GATGTGATCA TCTTCATCTC ACAGATGAAA AGAGACAAAC CTGGGATTCA GAGGTACTTG 000320
000321 CCTATGAGTT TCTTACAGAT TTCCTCTTAC AATCCAGAAC TGCTGATTCC TGGGTCAGTG TCCTTTCCAA TATGGCATCT 000400
000401 TAGGCATGGC AATAAGTGAG ATCTAAAAGC TAGTTATTTG ATGCTTGGAC AAAGGCTTAG GGCATGGGCT TTGACCTAAT 000480
000481 GAATCAGTAG ATTCTAGTCT AATATTTTAA AGGATTTGAA ATGATTCCAG TTTATAAGCC CCTTTAACTG TCTTCTAAGA 000560
000561 TGTGGCTAAA CATTCCAACC TTCCTTAGCT CAAAAGTGGA CAAAACAAGA GATTACACAT GTTGATACTT TGGGAGTCAT 000640
000641 AGAAAATTCA CATATACATA GGCAGAGTGG TTCTGTAATT AACCAAATCT TTAGAGGTCC AAGGTTAACA GTATTGACCA 000720
000721 TTCATAATTA GCCATAAACT CAGACATTTT AAAAGCCTCA TGAAAATAGA AGTATAGTTT TCAAATGTTA CAGACCCCAA 000800
000801 ACACCAGTGT TTTATTGCCT ACAGCAAGCA TAGCTCACAG ATCATCAC
000081 GGTTTTTACT GATGCCCTGC ACAGAGAGAG GTCTGTAAAG TGGCAAGCAG GAGTCTGCTA CAATGGAGGA AAGGATTTTG 000160
000161 CTGTATCTCT TGCCAGGCCC AAGGCTGCAG AGGGAATTGG TAATATACTT CATTTAATAA TAGTGTTTTA AGGGACATTA 000240
000241 TCATTTCATC CTATGTGGTA GATGTGATCA TCTTCATCTC ACAGATGAAA AGAGACAAAC CTGGGATTCA GAGGTACTTG 000320
000321 CCTATGAGTT TCTTACAGAT TTCCTCTTAC AATCCAGAAC TGCTGATTCC TGGGTCAGTG TCCTTTCCAA TATGGCATCT 000400
000401 TAGGCATGGC AATAAGTGAG ATCTAAAAGC TAGTTATTTG ATGCTTGGAC AAAGGCTTAG GGCATGGGCT TTGACCTAAT 000480
000481 GAATCAGTAG ATTCTAGTCT AATATTTTAA AGGATTTGAA ATGATTCCAG TTTATAAGCC CCTTTAACTG TCTTCTAAGA 000560
000561 TGTGGCTAAA CATTCCAACC TTCCTTAGCT CAAAAGTGGA CAAAACAAGA GATTACACAT GTTGATACTT TGGGAGTCAT 000640
000641 AGAAAATTCA CATATACATA GGCAGAGTGG TTCTGTAATT AACCAAATCT TTAGAGGTCC AAGGTTAACA GTATTGACCA 000720
000721 TTCATAATTA GCCATAAACT CAGACATTTT AAAAGCCTCA TGAAAATAGA AGTATAGTTT TCAAATGTTA CAGACCCCAA 000800
000801 ACACCAGTGT TTTATTGCCT ACAGCAAGCA TAGCTCACAG ATCATCAC
Labs working on this lncRNA
- Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
- Laboratory of Molecular Medicine, The Institute of Medical Science, The University of Tokyo, Japan.
References
- ↑ 1.0 1.1 1.2 Nishiwaki T, Daigo Y, Kawasoe T, Nakamura Y. Isolation and mutational analysis of a novel human cDNA, DEC1 (deleted in esophageal cancer 1), derived from the tumor suppressor locus in 9q32. Genes Chromosomes Cancer. 2000 Feb;27(2):169-76.
- ↑ Miura K, Suzuki K, Tokino T, Isomura M, Inazawa J, Matsuno S, Nakamura Y. Detailed deletion mapping in squamous cell carcinomas of the esophagus narrows a region containing a putative tumor suppressor gene to about 200 kilobases on distal chromosome 9q. Cancer Res. 1996 Apr 1;56(7):1629-34.
