MYOPARR
Revision as of 04:07, 12 August 2019 by Qianpeng Li (talk | contribs)
MYOPARR, a long noncoding RNA, is essential for the expression of human myogenin gene, which is one of the key myogenic transcription factors.
Contents
Annotated Information
Name
Approved symbol: MYOPARR
Approved name: MYOPARR: myogenin promoter-associated myogenic regulatory antisense long non-coding RNA.
HGNC ID: HGNC: 54178
RefSeq ID: NR_160550
Characteristics
MYOPARR contains a potential RNA nuclear retention signal at the 5’-side, a putative polyadenylation signal 15-nt upstream of the poly(A) tail, and a LINE-1-like sequence in the 3’-half[1].
Function
Proposed model of Myoparr function during myogenesis[1].
- MYOPARR is essential both for the specification of myoblasts by activating neighboring myogenin expression and for myoblast cell cycle withdrawal by activating myogenic microRNA expression. Mechanistically, MYOPARR interacts with Ddx17, a transcriptional coactivator of MyoD, and regulates the association between Ddx17 and the histone acetyltransferase PCAF[1].
- MYOPARR also promotes skeletal muscle atrophy caused by denervation, and knockdown of MYOPARR rescues muscle wasting in mice[1].
Regulation
MYOPARR expression is regulated by MyoD and TGF-b. During the conversion of C3H10T1/2 fibroblasts into myogenic cells by MyoD expression, a significant increase in MYOPARR expression was observed. In contrast, TGF-b treatment significantly decreased Myoparr expression during C2C12 differentiation[1].
Diseases
Expression
MYOPARR is co-expressed with myogenin, the expression of which is highly restricted to myogenic tissues in embryonic, fetal, and adult skeletal muscles [1].
Evolution
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Sequence
>NR_160550.1 Homo sapiens myogenin promoter associated myogenic regulatory antisense long non coding RNA (MYOPARR), long non-coding RNA
000001 AGAGCTGGCT TCCTAGCATC AGGGCAGCCT GGCTTAGGAG GCCCCTGCTA CAGAAGTAGT GGCATCTGTG GCCAGCTTGG 000080
000081 GGGGCTCGCA AGGATGCCCG GCTTGGAAGA CAATCTCAGT TGGGCATGGT TTCATCTGGG AAGGCCACAG ACACATCTTC 000160
000161 CACTGTGATG CTGTCCACGA TGGAGGTGAG GGAGTGCAGG TTGTGGGCAT CTGTAGGGTC AGCCGTGAGC AGATGATCTG 000240
000241 TAAGGGGAGG TGGGAAGGTG GTACCTGGGT GAGCAGTGGG GGTTCTTGAG GCCCAGAATA GAGGATGGGA CCCTTGGGGT 000320
000321 GACAGAGGTT TTCCAGGACA GATGAATGAC AAAGCTCCGG AGTTCTACTC CCTAGTCCCT GCCTTTCCCC ATGCTCTGTG 000400
000401 AGTGTGTGTG TGTGTGTGTG TGTGTGTGTG TGTGTGTGTA TGCGCCTCTT TTCTGAACTC CCCTAGTAGG TAGGGTTTGG 000480
000481 AAGCAGCCAC TCAAGTTGGA GCAGGATGGA GCTCCCCAGA GACTGGACCT GCCCTTTGCT CGGCCCAGTT TTGCAGCACT 000560
000561 GACTCAGCAC TTCACAGGGA CCCCTGGGGC AGGGACATTG TCCTCTCTGT GGAGAAGGTC AACCACCAGG CATCAGCTGG 000640
000641 GGAGCTGCAG GAGCTACTAT CACTCCTTTG CTGGTCAAGA CTGCAGGGGC ACACAGAACC TCCCAGCCCA CCCTTTGGGC 000720
000721 CTTGGAGTCA GCAGGTCCCT AGAGAGACCC AAGGGAAGAG GACCGGAGCA AGGAATAAGG TAAGAGGGGA GAACCTGGCC 000800
000801 CAGGGAGGGA CTGAGGGATT GGAGCCAAGG TTACCAGTCA GGCCTTACTT ACCCCCTGGG TTGGCGCTGA ACTCCAGTGC 000880
000881 ACTGCCCCAC TCTGGACTGC AGGAGGCGCT GTGAGAGCTG CATTCGCTGG GCACCTGCAA GACAGGGCGA AGGCCCAAGG 000960
000961 TCGGGGCACA GCCATTCTTT GATGTCTCTC TCTGCCTAGT CCCAGTGGGC AGAAGTACCT GTGGTGGGGT TGGAGGGTGG 001040
001041 GCCACAGGCT GTGGCCTTCC AGCCCAGGCC ATCCCCAACC CCAGAATCTT TGTAACTAGC TCCTCTCACA CCCCAGAGGC 001120
001121 CCTGCTTCCA GGCCTTCCTG GCTTCCATCC TGGGTGGTGG TTCTGCTCTC ACAGGACACC AGCTTAAAGG GGTCCCTGGT 001200
001201 TCTCCTGACT CTGGCGATAA GGGTGATGGA GACAGATTTT GTGGCCCAGT GAAGGTCGCT CTGTGCAGGC CTGCTGGAGT 001280
001281 TCCAATGAGA CTGAGTGGGT TTTCTCTCTG CTCAGCCACA CCCAGGATGG GGGCAAAGCA GTCTTCTCTG GTGAACTTGG 001360
001361 CCTGGCCTTT TAGGCTCTGA CTCAGGCGCT GGGATTAATC CTCACCCTCA CCTGGGCTGA CTGTGGCCTT GCTCCTGATC 001440
001441 TTTCTTCAGT CCTATGTTCC CCACCCCAAC CCCTTCTGCA CTTCCTCCCC ACTGCCTTTA TCTTGTCTGG AAAGAACACA 001520
001521 GGACACAGGA GGTCAGCTGG ATAGCCCAGC TCTGACCAGG GAAGGGCTCC TGCAGCCCCT CGACCCTGTC TGGCACCTGC 001600
001601 ACCAACCCTC TGAGCCCCTC TTGGGGTCTT GAGGCTGTCC AGGTGCCTCC CTCTGGCCCC GTCCCCTTGG GGCAGGGGGA 001680
001681 TGGGATGGCC ACTTACCCCT GGCTGGGGCC CGCCCCCGCC CCGGTAGCGG AGGTCACGCT CCTCCTGGTT GAGGGAGCTG 001760
001761 AGCAGGGCCT GGAGGCGCTC GATGTACTGG ATGGCACTGC GCAGGATCTC CACCTTGGGC AGCCGCTGGT TGGGGTTGAG 001840
001841 CAGGGTGCTT CTCTTCAGGG CCTCGAAGGC CTCATTCACC TTCTTGAGCC TGCGCTTCTC CCTCAGTGTG GCCGCCCGCC 001920
001921 GCCGGTCCAC GGACACCGAC TTCCTCTTAC ACACCTTACA CGCCCACGGC AGGCACTGGC CTGGACAGTG CTCGGGGGTC 002000
002001 CCCAGCCCCT TGTCCTCAAG GGGCCCTGGG GCCTCGGGGC TCAGGGTGAG CTCCGTCCGC TCGTAGCCTG GTGGTTCGAA 002080
002081 GCCCTGGAGG TGGACAGGCA GGTAGTTTTC CCCATCATAG AAGCGGGGTT CCTGGTAGAA GTAGGGGGAT GTCTCATACA 002160
002161 GCTCCATGGG GTCGGAAAAG GCTTGTTCCT GCCACCAGCC CCCAAGCTCC AGCAGCCCCT CACGCCAACT GCTGGGTGCC 002240
002241 ATTTAAACCC TCCCCGCTGG CATGGAACCA GAGATAAATA TAGCCAACGC CACAGAAACC TGAGCCCCCT CTAAGCTGTT 002320
002321 GCTGCACATC AAGGCGTTTA CAGTGGATTA GATGTGATTC CCCTTCTTTC TCCCGCATGG CCCCCACCCC ACCCTGCCAG 002400
002401 CCTGCCCCTG GCCCAGGCGG GCTCCTGTGC ACGGGTCGGG AGGCCGTCGG GTGTAATTTG ATTAGTTTTC ATTTCTCAGC 002480
002481 AGCCCCTGTG GGGCAGGGGC GTTGGGGGAG GACACATTCC CCTCTCATCT GCTCCTTTCA ATTACTCCTA GCTGGGCGGC 002560
002561 CTGCCTGCTG TCTCCTTGCA GTCCCGAAGA AGCTGGTGGG TATAGGGGGA GGAGGGAACA AGGAAGGGTA GGCTTAGGCT 002640
002641 GGAAGGGGCC TTAAGAGCCA ACTTATCCAT CTCCTTGCTT CCTGACAGCA CCTTAACCAC ACTACATCAG TCGATGAGAC 002720
002721 TCTTTTAAAG ACTTCCCTCC GGAAAGAATG GGACTGCTTC AGATTCTGGG CATTCATGGG CACTCAGTAT CCAGGGATAA 002800
002801 GAAGGATCAA GACTCAGAGC AGCTAACAGA TTCCACTTTT GGGGTTCCCA AGCAGCTTTG AGCTGTATGT TCTCTTAGGT 002880
002881 CTCATCTGGG GGGGTAAATT GAGGCAAGAG AAATTATTTG GGTTTTGGTT TTCTTGGCAG GGGTAAAGAG AAATTTCCTC 002960
002961 TTTAATACAG CAGCCGTGGT CAGAGCAGAG ATTAGAATTT ACAGCCTACA CGTTGCCACC TTCCCCAGAG CGGCAAGGTC 003040
003041 AAGATGTCCT AAGCTCCCTG TCTCCTCCCT GTCTCACTCC GGACCATTGA TCTGTCCTTC TATGTTACCT CCTCAACTCT 003120
003121 TTTTCCAACA CCAGAATTTT CCTGGCTCAT TAATGTGGAC GGGGGTGAAA AAGTAGAAAA AACAGAGCCC TTCAAACTCA 003200
003201 GTTTAAATCT CCTCTCTCCT TGGCCACCGG GCTTGGTTGT TCTGCCTCTT ACTGTCTGAG CCATCAATTT TACACGTATC 003280
003281 ATGCAGGTCT CAAATGTCAG GTAGAGCAGG GACTATTTAA TCTTCAGGCC TCTCAGGCCA TGGTCACCTC TCAGTAGGTG 003360
003361 CCTCAGGGTC TGAGAGGACA AATTCCTTCC AATGCAGTGG GCAGACCTTA GACACTAGCA GTGAACAAGG CTCAGTCTTA 003440
003441 GGGCTGGGGA TTATAGGGAC ACCCCAGACA GGATCCCTGC CCTCGAACTT ACCATCTGAT AGACAACGGT GATCACCTCT 003520
003521 TTCTACCTAG CCCCTGATGC CCAAATCTCC TCCGAGGCGG CTACTGTTCA GCTTCTGCTC ACGTCAGGAG ACAGCCCGTT 003600
003601 CCATTGACGT GTAGCTTTGG GCTGCAATCT GCTCCCTCTA TCTTTTATCC TTTGTTCCCA GTTTTTTCCT CCCCATAGAC 003680
003681 TAATGTCCTG CTCCTTATCC TACGACAGAT CAAACTGACA AGTTCAAGCC AGTGGCAAGG ACAATAAGAG GAAGGGGAAC 003760
003761 CCTGCTGGGG ACTCATGGGA GACTTCACAG GGAACATGAG ATCTGCGAGG CATGTGAAGA ACCAGTGTTC CTTCCTCTCA 003840
003841 TTATTCACAG CAGGGAGCCA GGAGAATTCT GATGTCCTTT TGGGACAGGA AATGGAGGGA AGGAGGGAAC ATAGCTGGAC 003920
003921 AACAAAAGAA CCCTAAGCAT GTTGAGGGAG AGCAGTGAGG TCTTAATTCT GTTCTTGGCC TTACCAGCAT GATAGAAAGT 004000
004001 AGCAGCATAG GCCGGGCGTG GTGGCTCATG CCTGTAGTCC TAGCACTTTG GGAGGCCAAG GCGGGTGGAT CACGAGGTCA 004080
004081 GGAGTTCAAG ACCAGCCTGG CCAAGATGGT GAAACCCTGT CTCTACTAAA AATACAAAAA TTAGCCAGGC ATGGTGGTGG 004160
004161 GCACTGTAAT CCCAGCTACT TGGGAGGCTG AGGCAGGGAA TTACTTGAAC TCAGGAGGAG GAGGTTGCAG TGAGCCGAGT 004240
004241 TCGCACCACT GTACTCCAGT CTGGGTGACA CAGCGAGACT CTGCCTCAAA AAAAAAAAAA AAAAAAAAAA AAAAAAGTAG 004320
004321 CAGCATAGGT ACTGTGTGGG TTCTAAACTT TGCTTTCCCC TGACCAGCTG GGCTGAAGAA GAGTCTCTAT TTCTAACACA 004400
004401 TCCCCTGCCA AACAAAAAAG AAAAAAAAAG CCTCAGTTTA CCCTCCAGTC CTATGAGCCC TGAGAAAAGA AGTCATGTTG 004480
004481 AAGCCACTAT AGGAACCCCC ATATTTGCAT CTTTTGTTAT TCCAGGATCC AGTGTGACTT ACCTCT
000081 GGGGCTCGCA AGGATGCCCG GCTTGGAAGA CAATCTCAGT TGGGCATGGT TTCATCTGGG AAGGCCACAG ACACATCTTC 000160
000161 CACTGTGATG CTGTCCACGA TGGAGGTGAG GGAGTGCAGG TTGTGGGCAT CTGTAGGGTC AGCCGTGAGC AGATGATCTG 000240
000241 TAAGGGGAGG TGGGAAGGTG GTACCTGGGT GAGCAGTGGG GGTTCTTGAG GCCCAGAATA GAGGATGGGA CCCTTGGGGT 000320
000321 GACAGAGGTT TTCCAGGACA GATGAATGAC AAAGCTCCGG AGTTCTACTC CCTAGTCCCT GCCTTTCCCC ATGCTCTGTG 000400
000401 AGTGTGTGTG TGTGTGTGTG TGTGTGTGTG TGTGTGTGTA TGCGCCTCTT TTCTGAACTC CCCTAGTAGG TAGGGTTTGG 000480
000481 AAGCAGCCAC TCAAGTTGGA GCAGGATGGA GCTCCCCAGA GACTGGACCT GCCCTTTGCT CGGCCCAGTT TTGCAGCACT 000560
000561 GACTCAGCAC TTCACAGGGA CCCCTGGGGC AGGGACATTG TCCTCTCTGT GGAGAAGGTC AACCACCAGG CATCAGCTGG 000640
000641 GGAGCTGCAG GAGCTACTAT CACTCCTTTG CTGGTCAAGA CTGCAGGGGC ACACAGAACC TCCCAGCCCA CCCTTTGGGC 000720
000721 CTTGGAGTCA GCAGGTCCCT AGAGAGACCC AAGGGAAGAG GACCGGAGCA AGGAATAAGG TAAGAGGGGA GAACCTGGCC 000800
000801 CAGGGAGGGA CTGAGGGATT GGAGCCAAGG TTACCAGTCA GGCCTTACTT ACCCCCTGGG TTGGCGCTGA ACTCCAGTGC 000880
000881 ACTGCCCCAC TCTGGACTGC AGGAGGCGCT GTGAGAGCTG CATTCGCTGG GCACCTGCAA GACAGGGCGA AGGCCCAAGG 000960
000961 TCGGGGCACA GCCATTCTTT GATGTCTCTC TCTGCCTAGT CCCAGTGGGC AGAAGTACCT GTGGTGGGGT TGGAGGGTGG 001040
001041 GCCACAGGCT GTGGCCTTCC AGCCCAGGCC ATCCCCAACC CCAGAATCTT TGTAACTAGC TCCTCTCACA CCCCAGAGGC 001120
001121 CCTGCTTCCA GGCCTTCCTG GCTTCCATCC TGGGTGGTGG TTCTGCTCTC ACAGGACACC AGCTTAAAGG GGTCCCTGGT 001200
001201 TCTCCTGACT CTGGCGATAA GGGTGATGGA GACAGATTTT GTGGCCCAGT GAAGGTCGCT CTGTGCAGGC CTGCTGGAGT 001280
001281 TCCAATGAGA CTGAGTGGGT TTTCTCTCTG CTCAGCCACA CCCAGGATGG GGGCAAAGCA GTCTTCTCTG GTGAACTTGG 001360
001361 CCTGGCCTTT TAGGCTCTGA CTCAGGCGCT GGGATTAATC CTCACCCTCA CCTGGGCTGA CTGTGGCCTT GCTCCTGATC 001440
001441 TTTCTTCAGT CCTATGTTCC CCACCCCAAC CCCTTCTGCA CTTCCTCCCC ACTGCCTTTA TCTTGTCTGG AAAGAACACA 001520
001521 GGACACAGGA GGTCAGCTGG ATAGCCCAGC TCTGACCAGG GAAGGGCTCC TGCAGCCCCT CGACCCTGTC TGGCACCTGC 001600
001601 ACCAACCCTC TGAGCCCCTC TTGGGGTCTT GAGGCTGTCC AGGTGCCTCC CTCTGGCCCC GTCCCCTTGG GGCAGGGGGA 001680
001681 TGGGATGGCC ACTTACCCCT GGCTGGGGCC CGCCCCCGCC CCGGTAGCGG AGGTCACGCT CCTCCTGGTT GAGGGAGCTG 001760
001761 AGCAGGGCCT GGAGGCGCTC GATGTACTGG ATGGCACTGC GCAGGATCTC CACCTTGGGC AGCCGCTGGT TGGGGTTGAG 001840
001841 CAGGGTGCTT CTCTTCAGGG CCTCGAAGGC CTCATTCACC TTCTTGAGCC TGCGCTTCTC CCTCAGTGTG GCCGCCCGCC 001920
001921 GCCGGTCCAC GGACACCGAC TTCCTCTTAC ACACCTTACA CGCCCACGGC AGGCACTGGC CTGGACAGTG CTCGGGGGTC 002000
002001 CCCAGCCCCT TGTCCTCAAG GGGCCCTGGG GCCTCGGGGC TCAGGGTGAG CTCCGTCCGC TCGTAGCCTG GTGGTTCGAA 002080
002081 GCCCTGGAGG TGGACAGGCA GGTAGTTTTC CCCATCATAG AAGCGGGGTT CCTGGTAGAA GTAGGGGGAT GTCTCATACA 002160
002161 GCTCCATGGG GTCGGAAAAG GCTTGTTCCT GCCACCAGCC CCCAAGCTCC AGCAGCCCCT CACGCCAACT GCTGGGTGCC 002240
002241 ATTTAAACCC TCCCCGCTGG CATGGAACCA GAGATAAATA TAGCCAACGC CACAGAAACC TGAGCCCCCT CTAAGCTGTT 002320
002321 GCTGCACATC AAGGCGTTTA CAGTGGATTA GATGTGATTC CCCTTCTTTC TCCCGCATGG CCCCCACCCC ACCCTGCCAG 002400
002401 CCTGCCCCTG GCCCAGGCGG GCTCCTGTGC ACGGGTCGGG AGGCCGTCGG GTGTAATTTG ATTAGTTTTC ATTTCTCAGC 002480
002481 AGCCCCTGTG GGGCAGGGGC GTTGGGGGAG GACACATTCC CCTCTCATCT GCTCCTTTCA ATTACTCCTA GCTGGGCGGC 002560
002561 CTGCCTGCTG TCTCCTTGCA GTCCCGAAGA AGCTGGTGGG TATAGGGGGA GGAGGGAACA AGGAAGGGTA GGCTTAGGCT 002640
002641 GGAAGGGGCC TTAAGAGCCA ACTTATCCAT CTCCTTGCTT CCTGACAGCA CCTTAACCAC ACTACATCAG TCGATGAGAC 002720
002721 TCTTTTAAAG ACTTCCCTCC GGAAAGAATG GGACTGCTTC AGATTCTGGG CATTCATGGG CACTCAGTAT CCAGGGATAA 002800
002801 GAAGGATCAA GACTCAGAGC AGCTAACAGA TTCCACTTTT GGGGTTCCCA AGCAGCTTTG AGCTGTATGT TCTCTTAGGT 002880
002881 CTCATCTGGG GGGGTAAATT GAGGCAAGAG AAATTATTTG GGTTTTGGTT TTCTTGGCAG GGGTAAAGAG AAATTTCCTC 002960
002961 TTTAATACAG CAGCCGTGGT CAGAGCAGAG ATTAGAATTT ACAGCCTACA CGTTGCCACC TTCCCCAGAG CGGCAAGGTC 003040
003041 AAGATGTCCT AAGCTCCCTG TCTCCTCCCT GTCTCACTCC GGACCATTGA TCTGTCCTTC TATGTTACCT CCTCAACTCT 003120
003121 TTTTCCAACA CCAGAATTTT CCTGGCTCAT TAATGTGGAC GGGGGTGAAA AAGTAGAAAA AACAGAGCCC TTCAAACTCA 003200
003201 GTTTAAATCT CCTCTCTCCT TGGCCACCGG GCTTGGTTGT TCTGCCTCTT ACTGTCTGAG CCATCAATTT TACACGTATC 003280
003281 ATGCAGGTCT CAAATGTCAG GTAGAGCAGG GACTATTTAA TCTTCAGGCC TCTCAGGCCA TGGTCACCTC TCAGTAGGTG 003360
003361 CCTCAGGGTC TGAGAGGACA AATTCCTTCC AATGCAGTGG GCAGACCTTA GACACTAGCA GTGAACAAGG CTCAGTCTTA 003440
003441 GGGCTGGGGA TTATAGGGAC ACCCCAGACA GGATCCCTGC CCTCGAACTT ACCATCTGAT AGACAACGGT GATCACCTCT 003520
003521 TTCTACCTAG CCCCTGATGC CCAAATCTCC TCCGAGGCGG CTACTGTTCA GCTTCTGCTC ACGTCAGGAG ACAGCCCGTT 003600
003601 CCATTGACGT GTAGCTTTGG GCTGCAATCT GCTCCCTCTA TCTTTTATCC TTTGTTCCCA GTTTTTTCCT CCCCATAGAC 003680
003681 TAATGTCCTG CTCCTTATCC TACGACAGAT CAAACTGACA AGTTCAAGCC AGTGGCAAGG ACAATAAGAG GAAGGGGAAC 003760
003761 CCTGCTGGGG ACTCATGGGA GACTTCACAG GGAACATGAG ATCTGCGAGG CATGTGAAGA ACCAGTGTTC CTTCCTCTCA 003840
003841 TTATTCACAG CAGGGAGCCA GGAGAATTCT GATGTCCTTT TGGGACAGGA AATGGAGGGA AGGAGGGAAC ATAGCTGGAC 003920
003921 AACAAAAGAA CCCTAAGCAT GTTGAGGGAG AGCAGTGAGG TCTTAATTCT GTTCTTGGCC TTACCAGCAT GATAGAAAGT 004000
004001 AGCAGCATAG GCCGGGCGTG GTGGCTCATG CCTGTAGTCC TAGCACTTTG GGAGGCCAAG GCGGGTGGAT CACGAGGTCA 004080
004081 GGAGTTCAAG ACCAGCCTGG CCAAGATGGT GAAACCCTGT CTCTACTAAA AATACAAAAA TTAGCCAGGC ATGGTGGTGG 004160
004161 GCACTGTAAT CCCAGCTACT TGGGAGGCTG AGGCAGGGAA TTACTTGAAC TCAGGAGGAG GAGGTTGCAG TGAGCCGAGT 004240
004241 TCGCACCACT GTACTCCAGT CTGGGTGACA CAGCGAGACT CTGCCTCAAA AAAAAAAAAA AAAAAAAAAA AAAAAAGTAG 004320
004321 CAGCATAGGT ACTGTGTGGG TTCTAAACTT TGCTTTCCCC TGACCAGCTG GGCTGAAGAA GAGTCTCTAT TTCTAACACA 004400
004401 TCCCCTGCCA AACAAAAAAG AAAAAAAAAG CCTCAGTTTA CCCTCCAGTC CTATGAGCCC TGAGAAAAGA AGTCATGTTG 004480
004481 AAGCCACTAT AGGAACCCCC ATATTTGCAT CTTTTGTTAT TCCAGGATCC AGTGTGACTT ACCTCT
Labs working on this lncRNA
- Division for Therapies against Intractable Diseases, Institute for Comprehensive Medical Science (ICMS), Fujita Health University, Toyoake, Japan.
- Department of Medical Technology, School of Health Sciences, Gifu University of Medical Science, Seki, Japan.
