DGCR9
Revision as of 02:39, 13 August 2019 by Qianpeng Li (talk | contribs)
Contents
Annotated Information
Name
Approved Symbol: DGCR9
Approved Name: DiGeorge syndrome critical region gene 9 (non-protein coding)
Synonyms: DGS-A, POM121L5P
Chromosome: 22q11.21
RefSeq ID: NR_024159
Ensembl ID: ENSG00000273032
LncBook transcript ID: HSALNT0275220
Characteristics
Function
- DGCR9 was positively associated with lymph node invasion and tumor-node-metastasis (TNM) stage in gastric cancer patients. By in vitro functional analysis, knockdown of DGCR9 in gastric cancer cells suppressed cellular proliferation, migration, and glucose uptake. In contrast, overexpression of DGCR9 increased each of these cancer cell characteristics[1].
Regulation
Diseases
Gastric cancer[1].
Expression
DGCR9 was significantly upregulated in gastric cancer tissues and cell lines[1].
| Experiment | Forward primer | Reverse primer |
|---|---|---|
| Quantitative real-time PCR | 5'-TAGCATGGCCAGGTATGCAC- 3' | 5'-TGCGAATCCCAAAGCTGTCA- 3'[1] |
Evolution
Sequence
>gi|205830460|ref|NR_024159.1| Homo sapiens DiGeorge syndrome critical region gene 9 (non-protein coding) (DGCR9), long non-coding RNA
000001 GTAAAACTCA TATGAAACCA AAAAAGAGCT CAAAGAGCCA AAGTCATCCT CAGCAAAAAC AACAAAACTA GAAGCACCCC 000080
000081 ATTTCACTGC AAATTAGAAT GACAAAATTT TTGACAAGTG CATGGTAACC AAAACAGCAT GGTCCTAGCA TAAAACTAGA 000160
000161 CACATAGATC AATGGGACGG ATGACAGAGC CCAGAAAGAC AGCCACATAG TCTTGGGGCT TGTGTCTCTC CTGCTGTGCA 000240
000241 TCCATGCTGG GTGCTTTACA TACAACAGGC AGACAAGAAG TCCCTGTTGC AAGTGAGGAC AAAGTGTGGG AAGGCCGTGA 000320
000321 GGGTCTGCAG TCCCAGATGG CCTTGGCCTC ACCCCGCAGT GCGCTTTTGC ACCAGAGTGC CACCTTCTTC TCCAGGTCCA 000400
000401 GGTCTTCAGC AGTGACCCCA GACCCCAGCT GTAAGGGAGG TGGCAGCATC AGAGGCTCCC CTTGCCTGAG TGGCAGCAGA 000480
000481 GGAAACTTGC ATCTATGGGG CCTAGAGGCC TGGGATGTGG GGGAGCCATT CCTGGGGGCA AGTGTCTGCC CTGGTGCTGC 000560
000561 ATCTGCTGCC TTTTCACACT GGGTGAGACC CCAAGAGACA GCCTGAGGCC GGTCCTCACT CACTGTCTTT GAGGACCTGA 000640
000641 GGGGCAGCTG ACAGTGGGAT GAGGCTGGCC CCCTCCTCTT TGGTGACAGG AAGCCTCCCA TGGAACTGTA GGAGCTCACG 000720
000721 ATGGCATTTT GTTTGGTGCA CGAACTCATC CAGGAGGTCT GGGATCTCTG GTTTTATCCG ACTTCTGACC TCTGGGCATG 000800
000801 GAGGTCTCTC TGCAGAGGCC CAGGCCTGGG CACGAAGGGA GAGAGGCCTC CATTGTCCCA CAGGGGCCTA AATGCAGACT 000880
000881 GTGCATCCCC GGTGCCCTCA GGAACCCTTC TCTGATCATC AGGATTCTCT TGGACTCTGG GGTCCTTGTC CTGCTCAGGC 000960
000961 ATCCCTGCCC CCCTCTTCAG GAGGGCCCTC AACACGATCT TCTCTGGACA GGAGTCTGGG GCACAACTGG ATGTTGTGGG 001040
001041 CCCCAAAGGG GTGACTCCCT GCTCCTGGGC CCCACAGAGA GTCCTTGTGC TCAGTGCACT GGCTGAGCTG CAAGACATCC 001120
001121 TGGAATTGGG AGCACACAGC ACCGGCTTGC TGTGGTACCT GTGCATTCAA ATTGAAGGCA GGATCGCCAG CAAGGAACAC 001200
001201 AGGGCTTGCA GGATCACAGA AAACCCTTGG AGTTGTTTTG ACACACCACT GATGCCAAGT GTCTGGGTAC TTGTAGGATG 001280
001281 GCCCTGCCAT TCCATCCAGG GGCAGTGGCA ACAGGGAGAT TCCACAAACA AAGTGAACTG GGGGATGGGA TGAGCAGGCT 001360
001361 CCAGGCAACT GAGCCCTACT GGCAGGCCCT TGGCCCCCGG GGCCGGGACA GGGGTGACAG ACACAGAGTG CCCAGGTAAC 001440
001441 CACTCCTGGG AGCAGTGGGG AACCGTCGGA TGCTTCAACT CTTGAGAGCT GGGCTCTAAG CATCCGCCTT AGCTGCCAAC 001520
001521 TTGGCCAAAG GCTATGCGAG CAGTTTCCCG TTGACGGGCA ATGCATCTTT CCAACCTGAG CGAGTGGGTG TGTGTGCAAA 001600
001601 GATGGTGCGA GTCACGGATC TGCGCAGGAA GGGTGACTTT AAGGGATTAG CATGGCCAGG TATGCACACA AGGCACCTGC 001680
001681 TGGCAATGCC TTGGTGGGGA GCGGGCAGTG CACACAAGAG GTACTGGAGG GAGAGGCGCG CGGGAAGAAC AGGCGCGCAC 001760
001761 AATGGCTGCA GATCCACCTG TGGATCGCTG AAGATTCCTG CTGAGGGTTG AGGCTGCTGG GCTGGAGGAC TGTATGGTCC 001840
001841 ATGCATTGTA ATGTCCCCTT CTCTCCCTGG CCCGGAGCCC CAAGAGCTAT CCGGACTCTC TCCAAGACCT GGTTCTGGCC 001920
001921 CAGCAAAGAG GTCTCGGCAG GGGAGCAGGA TTCCCGGCCC AGCAGCTGGC TCAGGAGGTG ACAGCTTTGG GATTCGCATC 002000
002001 TGAGCATCCT CCTACTCTTC TCCTGGGAAC TCTGTTGGGG AGGGTTGCTC AGAACAGAAG TGCCTGGGAC GCCCAGATCC 002080
002081 TGCTGGAGTG GCAGCTGGGG TGATGGCCAG GGCAGGCTGG GAGGGACATA CTTTCCATAG GACCCAGTGC TTTCATCTCC 002160
002161 GTGCAACTGA CCAAGAGAAA CCAAACCCAA ACTCCTTCCT TTACACAGAC CTATTTGAGG GAGGCTGGGT ATTGTTTGTG 002240
002241 TATTTCAACC TAACAAGATT TTGAGATAGT TGGAATGCAG AAGGAGACAG GAGGACTCAA GTGTCCTGTC TTTTGCAAAA 002320
002321 ATGTCAAACG TAGCTACTCA GTCTCTTTTT TGTTTTTTTG TTTGTTTTGA AGACTATGGT TATTTTGCAA AATATATATT 002400
002401 ATTTGAGTTT CTCTAAAAAA AAAAAAAAAA AAAA
000081 ATTTCACTGC AAATTAGAAT GACAAAATTT TTGACAAGTG CATGGTAACC AAAACAGCAT GGTCCTAGCA TAAAACTAGA 000160
000161 CACATAGATC AATGGGACGG ATGACAGAGC CCAGAAAGAC AGCCACATAG TCTTGGGGCT TGTGTCTCTC CTGCTGTGCA 000240
000241 TCCATGCTGG GTGCTTTACA TACAACAGGC AGACAAGAAG TCCCTGTTGC AAGTGAGGAC AAAGTGTGGG AAGGCCGTGA 000320
000321 GGGTCTGCAG TCCCAGATGG CCTTGGCCTC ACCCCGCAGT GCGCTTTTGC ACCAGAGTGC CACCTTCTTC TCCAGGTCCA 000400
000401 GGTCTTCAGC AGTGACCCCA GACCCCAGCT GTAAGGGAGG TGGCAGCATC AGAGGCTCCC CTTGCCTGAG TGGCAGCAGA 000480
000481 GGAAACTTGC ATCTATGGGG CCTAGAGGCC TGGGATGTGG GGGAGCCATT CCTGGGGGCA AGTGTCTGCC CTGGTGCTGC 000560
000561 ATCTGCTGCC TTTTCACACT GGGTGAGACC CCAAGAGACA GCCTGAGGCC GGTCCTCACT CACTGTCTTT GAGGACCTGA 000640
000641 GGGGCAGCTG ACAGTGGGAT GAGGCTGGCC CCCTCCTCTT TGGTGACAGG AAGCCTCCCA TGGAACTGTA GGAGCTCACG 000720
000721 ATGGCATTTT GTTTGGTGCA CGAACTCATC CAGGAGGTCT GGGATCTCTG GTTTTATCCG ACTTCTGACC TCTGGGCATG 000800
000801 GAGGTCTCTC TGCAGAGGCC CAGGCCTGGG CACGAAGGGA GAGAGGCCTC CATTGTCCCA CAGGGGCCTA AATGCAGACT 000880
000881 GTGCATCCCC GGTGCCCTCA GGAACCCTTC TCTGATCATC AGGATTCTCT TGGACTCTGG GGTCCTTGTC CTGCTCAGGC 000960
000961 ATCCCTGCCC CCCTCTTCAG GAGGGCCCTC AACACGATCT TCTCTGGACA GGAGTCTGGG GCACAACTGG ATGTTGTGGG 001040
001041 CCCCAAAGGG GTGACTCCCT GCTCCTGGGC CCCACAGAGA GTCCTTGTGC TCAGTGCACT GGCTGAGCTG CAAGACATCC 001120
001121 TGGAATTGGG AGCACACAGC ACCGGCTTGC TGTGGTACCT GTGCATTCAA ATTGAAGGCA GGATCGCCAG CAAGGAACAC 001200
001201 AGGGCTTGCA GGATCACAGA AAACCCTTGG AGTTGTTTTG ACACACCACT GATGCCAAGT GTCTGGGTAC TTGTAGGATG 001280
001281 GCCCTGCCAT TCCATCCAGG GGCAGTGGCA ACAGGGAGAT TCCACAAACA AAGTGAACTG GGGGATGGGA TGAGCAGGCT 001360
001361 CCAGGCAACT GAGCCCTACT GGCAGGCCCT TGGCCCCCGG GGCCGGGACA GGGGTGACAG ACACAGAGTG CCCAGGTAAC 001440
001441 CACTCCTGGG AGCAGTGGGG AACCGTCGGA TGCTTCAACT CTTGAGAGCT GGGCTCTAAG CATCCGCCTT AGCTGCCAAC 001520
001521 TTGGCCAAAG GCTATGCGAG CAGTTTCCCG TTGACGGGCA ATGCATCTTT CCAACCTGAG CGAGTGGGTG TGTGTGCAAA 001600
001601 GATGGTGCGA GTCACGGATC TGCGCAGGAA GGGTGACTTT AAGGGATTAG CATGGCCAGG TATGCACACA AGGCACCTGC 001680
001681 TGGCAATGCC TTGGTGGGGA GCGGGCAGTG CACACAAGAG GTACTGGAGG GAGAGGCGCG CGGGAAGAAC AGGCGCGCAC 001760
001761 AATGGCTGCA GATCCACCTG TGGATCGCTG AAGATTCCTG CTGAGGGTTG AGGCTGCTGG GCTGGAGGAC TGTATGGTCC 001840
001841 ATGCATTGTA ATGTCCCCTT CTCTCCCTGG CCCGGAGCCC CAAGAGCTAT CCGGACTCTC TCCAAGACCT GGTTCTGGCC 001920
001921 CAGCAAAGAG GTCTCGGCAG GGGAGCAGGA TTCCCGGCCC AGCAGCTGGC TCAGGAGGTG ACAGCTTTGG GATTCGCATC 002000
002001 TGAGCATCCT CCTACTCTTC TCCTGGGAAC TCTGTTGGGG AGGGTTGCTC AGAACAGAAG TGCCTGGGAC GCCCAGATCC 002080
002081 TGCTGGAGTG GCAGCTGGGG TGATGGCCAG GGCAGGCTGG GAGGGACATA CTTTCCATAG GACCCAGTGC TTTCATCTCC 002160
002161 GTGCAACTGA CCAAGAGAAA CCAAACCCAA ACTCCTTCCT TTACACAGAC CTATTTGAGG GAGGCTGGGT ATTGTTTGTG 002240
002241 TATTTCAACC TAACAAGATT TTGAGATAGT TGGAATGCAG AAGGAGACAG GAGGACTCAA GTGTCCTGTC TTTTGCAAAA 002320
002321 ATGTCAAACG TAGCTACTCA GTCTCTTTTT TGTTTTTTTG TTTGTTTTGA AGACTATGGT TATTTTGCAA AATATATATT 002400
002401 ATTTGAGTTT CTCTAAAAAA AAAAAAAAAA AAAA
Labs working on this lncRNA
- Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo, People’s Republic of China.
