ATP2C2-AS1
Revision as of 07:33, 13 August 2019 by Qianpeng Li (talk | contribs)
Contents
Annotated Information
Name
Approved symbol: ATP2C2-AS1:ATP2C2 antisense RNA 1
Alias symbols : RP11-517C16.2-001 [1], RP11-517C16.2
HGNC ID : HGNC:53167
LncBook transcript ID: HSALNT0289472
Characteristics
-
Function
RP11-517C16.2 shares identical sequences with LoNA on NCL and FBL-binding sites, indicating that RP11-517C16.2 maybe functionally similar to LoNA[1].
Regulation
-
Diseases
-
Expression
RP11-517C16.2-001 is significantly upregulated (33.479-fold) in Botulinum Toxin Type A (BoNTA )(5 U 48 h) treated human dermal fibroblasts [2].
According to GTEx Portal(v7), RP11-517C16.2 is ubiquitously expressed in human tissues, with relatively high levels in brain tissue. We further examined its expression level in different human cell lines, and found that it is abundantly expressed in SH-SY5Y cells, and barely expressed in 293T, U2OS, and U87 cells[1].
Sequence
>NR_146503.1 Homo sapiens ATP2C2 antisense RNA 1 (ATP2C2-AS1), long non-coding RNA
000001 ATCAGAAGGC CTGGGCAGAC TTGGCCAGCC ACCTGGAGCA CTGTGCCCTT AAACTCAGGG CATTCACTGG TGACCCACAC 000080
000081 TGACACTGCT TTTTGGAGGA CAAGGCAGAG TTGACCATCC CAGTCTTGCC TGGAGGTCAT AGGACCGTTG TCACTGCAGC 000160
000161 CTCAGGTCTG ATGCATAATC CCATGACCCT CCAGATCTGA GCCATGACCC ACTCTGGGCC CTGCCGGCGG GGAGGCGGTG 000240
000241 GGCCCATGGG GGCTGCCTCA CTGGCCTCCC TCGTCCTCTA TTCCGGGTTG GGGTTGGCTC TCAGCACACT GGGGAAAAGG 000320
000321 GTGGGGTCGA TGACTTGTCC CTGGCTCCCT CCCCTTGCCC CATGCCTGCC ATAACCGCAG CTTCAGAGAA AGGTGCCACA 000400
000401 CTCGCTTGGC TGACAATGTC GGGGAGTCCC CTGGGCTCCA CACCAGGGCG TGTGCCCTTG GAAAACCACG GTGACTGAAT 000480
000481 CATGTCCCTT TCAGCCAAAA CTGGAAGACA GCCCAGCTCC CTGCCTTCAG GTGACCAGAT CTCTAAGTCA CATTACTGGC 000560
000561 CCCAGGGTCA AGTCCAGGCT CCCCAGCTGG GGTACCTCCC AGGCTGAGTA CAGGCCTTGC TCCCTCCTTC CTCCCTGCAC 000640
000641 GTGCTCTGAG CCTCCAGCCC GACGCCTGGG ATGCCGGTGC CCCTTGGGCC CCAGACCCTA CTACTCTTGA GTGACAGGCC 000720
000721 TCTTCCTAGG GGTTTCTGTG CATCCGTCAC ATCACCCACG TTAGAGTCCC TTCCTGTGAG GACAGAAGGG CCCTGAAGAC 000800
000801 AGAGCCGGCC CCTGGTGAGC TCTGCTTTCC CGCACTGACC CCTCCTGGGC TGCAGCTCCC CACCTGGCAG CTGCCGCCCC 000880
000881 CCATGGCCCT GGTCGAGGTC ACCTGTCGTT CCCGTCCCCA CCACTCACCA AGCGCTCCCA GGTTCTCCGT CTGGAAGACC 000960
000961 CTCTGCAGCG GGGGGATGTA AATGACCGCC AGCTGCCCCA GGATGGACCC CAGGACGGAG TAGAGGAACA TGTGGTTCCT 001040
001041 GAGAAAGCCG ATCTCAAATA TCAGCTTGGT CTGCAGGGAG AAGGTCACAC GGGGGATTGT GTGCTGTCCA CACCCCAGGT 001120
001121 ACAGGCAGGG GAGCTCTGAC TGCCCACGCT GAGCCAGAGC CGCTCAATGC TGCGGGCAGG GTCGGGGCGC TGCTGTCGAG 001200
001201 AACACACAGC AGCTCTGCAG CGAGGAGGGT CAGCCCGGGT CTCACCTGAG AGCGGCAGGT CAAGGCGTTG AAGAGATCGA 001280
001281 AAAACACAAA ACAAGTGAAC GTCATCGTCG TGGTGCGGGG AGTGCTTGCT CTGTCTTCAG GCATCTGGAA GGTGAGCACA 001360
001361 AAGATGTGAG CTGTGGCAGG AGGGCAGGGA CTGCAGTCCC CAGCGTCTGC ACCGCACCAG GGCTTGGAGA ACAGGCCGGG 001440
001441 GTGACCCTCG CTCACCTCCT TCCAGAAGAT AAAGAGGGTC CCGCTGATGA TGATGGCCGC GGACATGAGG ATCTTCAGGA 001520
001521 TGAGGGCTCT GCTGAGGATG GTGTCCCGCA CACTCCGTGG TGGCTGCCTG AAGGCGTCTT TGTCAACGGG CTCTACCCCC 001600
001601 AAGCTGCTCC GAACAAGACA CAGACACTTT GAAATGAACC AGGAATGAAA TAAAGGACCC TTGAAACAGC TGTGCCTGAG 001680
001681 CCTCCCAGGC CAAGTTGGCA CAGGGGGCAG GGCCAGGCAT TTGCTGAACG CCCCCAGGCA TCGCACCTGC CCTCCTCGGC 001760
001761 ACCTTCCAGA AGCCCCAGAG CCTGGGTCCA TGGGCAGCTG TGCCCCTCCA TCTGTCCCGC AGACAGTGAA GGAAGACCAC 001840
001841 CCCGTAAGGC CAACCACACA CAGTTCCATA CACCCAGATG ATCTCCATCA CCCCGAGGGG ACCCCCCCCA ACGTTGCGCC 001920
001921 TGGAGAAACA GGCTCCAGGC TCCGCCCTCC GCAGAGCCCC TCATCAGCTG AGAGAGACCA GCCTCCAGCC AACTCCACAC 002000
002001 AGCAGGGTTG AGGCTAGACC CGCAGCAGGC GGTATGGTGG GAGTGGCCGG GTGAGGCCCT GCCGCTCAGA CACAGCTGAG 002080
002081 GCCAGCTTCC TGGTCCCACT TCTGCTCCCA GGGAGGGCTG GCAGGAGAGG TAACCCTCAC ACTTGGCTTT GGGGACACAA 002160
002161 ATGAGGACTC TCTTTCCCTT GGCAGCTATC ACTGGTGATA ACAGCAGCAC TGAGCTCCAG CGGAAGCACT GGCTCTGTGC 002240
002241 TCATACGGTT ACGCACACGT GGCCAGATGG GTCCCCTGAC TCCAAAGCGC ATTCCTTCCC CCACACCACT TGGCCAGCTT 002320
002321 GTTGAAGGGG ATATTAAGTG GCGGAGCGGG TGGACTCCTG AGCACCTACT GAGTGGCAAG CCCTTTATCT CTAGACATCA 002400
002401 GGGATGAAAC ACAAACTCCG CCTCCATGAA ACTGATGTTC TAAAGGGGAG ACAGATCACA ATCAGATCCA TAAGGAAAAG 002480
002481 TGTGTCTGTG TGTATCTTCC TCTCTAGGGA AAAATACAGC AGGGTGAGGG GATTGAGTGG GAGTGCAATC AGGGAAGACT 002560
002561 TCCTGAAGGC AGTGACTGGT GACTGGAATG AAGCATGAGA ATGAGCCATG CAGGTTGCCC AGAGAGAGCA TCCAGGCAGA 002640
002641 GGGAGCAGAA AGTTCCATCC TCACCCAGCT CTGCCGGCCC AGGTACTTTC TCCTCTGCCT TCTACTCCCA GTCTCACTGC 002720
002721 AGTGCAACAC ACTTCAGTTT TCTGGGAACT CCTGATGGAA AGTGGCTGTA TTTGTTCATC CCTATAGCCT TGGGGCACAG 002800
002801 CCAGCAGCCC CTGGAGGAAG CCCCGCAGGT GGGTAAAGAG ACACAGGGCT CCCAGCCGGC CCTGCCTCAC CTCTGCGCCG 002880
002881 GTGGCCCATC CATGATGATG TTGATCCATA GGATCTGCAT GGCGTTGAGG GGGCTGGGCA GGTTGAACAC GGTGGACAGA 002960
002961 GTGATGAGAC TCAGGGCGGA GATGCTCCTG CGGGGCAC
000081 TGACACTGCT TTTTGGAGGA CAAGGCAGAG TTGACCATCC CAGTCTTGCC TGGAGGTCAT AGGACCGTTG TCACTGCAGC 000160
000161 CTCAGGTCTG ATGCATAATC CCATGACCCT CCAGATCTGA GCCATGACCC ACTCTGGGCC CTGCCGGCGG GGAGGCGGTG 000240
000241 GGCCCATGGG GGCTGCCTCA CTGGCCTCCC TCGTCCTCTA TTCCGGGTTG GGGTTGGCTC TCAGCACACT GGGGAAAAGG 000320
000321 GTGGGGTCGA TGACTTGTCC CTGGCTCCCT CCCCTTGCCC CATGCCTGCC ATAACCGCAG CTTCAGAGAA AGGTGCCACA 000400
000401 CTCGCTTGGC TGACAATGTC GGGGAGTCCC CTGGGCTCCA CACCAGGGCG TGTGCCCTTG GAAAACCACG GTGACTGAAT 000480
000481 CATGTCCCTT TCAGCCAAAA CTGGAAGACA GCCCAGCTCC CTGCCTTCAG GTGACCAGAT CTCTAAGTCA CATTACTGGC 000560
000561 CCCAGGGTCA AGTCCAGGCT CCCCAGCTGG GGTACCTCCC AGGCTGAGTA CAGGCCTTGC TCCCTCCTTC CTCCCTGCAC 000640
000641 GTGCTCTGAG CCTCCAGCCC GACGCCTGGG ATGCCGGTGC CCCTTGGGCC CCAGACCCTA CTACTCTTGA GTGACAGGCC 000720
000721 TCTTCCTAGG GGTTTCTGTG CATCCGTCAC ATCACCCACG TTAGAGTCCC TTCCTGTGAG GACAGAAGGG CCCTGAAGAC 000800
000801 AGAGCCGGCC CCTGGTGAGC TCTGCTTTCC CGCACTGACC CCTCCTGGGC TGCAGCTCCC CACCTGGCAG CTGCCGCCCC 000880
000881 CCATGGCCCT GGTCGAGGTC ACCTGTCGTT CCCGTCCCCA CCACTCACCA AGCGCTCCCA GGTTCTCCGT CTGGAAGACC 000960
000961 CTCTGCAGCG GGGGGATGTA AATGACCGCC AGCTGCCCCA GGATGGACCC CAGGACGGAG TAGAGGAACA TGTGGTTCCT 001040
001041 GAGAAAGCCG ATCTCAAATA TCAGCTTGGT CTGCAGGGAG AAGGTCACAC GGGGGATTGT GTGCTGTCCA CACCCCAGGT 001120
001121 ACAGGCAGGG GAGCTCTGAC TGCCCACGCT GAGCCAGAGC CGCTCAATGC TGCGGGCAGG GTCGGGGCGC TGCTGTCGAG 001200
001201 AACACACAGC AGCTCTGCAG CGAGGAGGGT CAGCCCGGGT CTCACCTGAG AGCGGCAGGT CAAGGCGTTG AAGAGATCGA 001280
001281 AAAACACAAA ACAAGTGAAC GTCATCGTCG TGGTGCGGGG AGTGCTTGCT CTGTCTTCAG GCATCTGGAA GGTGAGCACA 001360
001361 AAGATGTGAG CTGTGGCAGG AGGGCAGGGA CTGCAGTCCC CAGCGTCTGC ACCGCACCAG GGCTTGGAGA ACAGGCCGGG 001440
001441 GTGACCCTCG CTCACCTCCT TCCAGAAGAT AAAGAGGGTC CCGCTGATGA TGATGGCCGC GGACATGAGG ATCTTCAGGA 001520
001521 TGAGGGCTCT GCTGAGGATG GTGTCCCGCA CACTCCGTGG TGGCTGCCTG AAGGCGTCTT TGTCAACGGG CTCTACCCCC 001600
001601 AAGCTGCTCC GAACAAGACA CAGACACTTT GAAATGAACC AGGAATGAAA TAAAGGACCC TTGAAACAGC TGTGCCTGAG 001680
001681 CCTCCCAGGC CAAGTTGGCA CAGGGGGCAG GGCCAGGCAT TTGCTGAACG CCCCCAGGCA TCGCACCTGC CCTCCTCGGC 001760
001761 ACCTTCCAGA AGCCCCAGAG CCTGGGTCCA TGGGCAGCTG TGCCCCTCCA TCTGTCCCGC AGACAGTGAA GGAAGACCAC 001840
001841 CCCGTAAGGC CAACCACACA CAGTTCCATA CACCCAGATG ATCTCCATCA CCCCGAGGGG ACCCCCCCCA ACGTTGCGCC 001920
001921 TGGAGAAACA GGCTCCAGGC TCCGCCCTCC GCAGAGCCCC TCATCAGCTG AGAGAGACCA GCCTCCAGCC AACTCCACAC 002000
002001 AGCAGGGTTG AGGCTAGACC CGCAGCAGGC GGTATGGTGG GAGTGGCCGG GTGAGGCCCT GCCGCTCAGA CACAGCTGAG 002080
002081 GCCAGCTTCC TGGTCCCACT TCTGCTCCCA GGGAGGGCTG GCAGGAGAGG TAACCCTCAC ACTTGGCTTT GGGGACACAA 002160
002161 ATGAGGACTC TCTTTCCCTT GGCAGCTATC ACTGGTGATA ACAGCAGCAC TGAGCTCCAG CGGAAGCACT GGCTCTGTGC 002240
002241 TCATACGGTT ACGCACACGT GGCCAGATGG GTCCCCTGAC TCCAAAGCGC ATTCCTTCCC CCACACCACT TGGCCAGCTT 002320
002321 GTTGAAGGGG ATATTAAGTG GCGGAGCGGG TGGACTCCTG AGCACCTACT GAGTGGCAAG CCCTTTATCT CTAGACATCA 002400
002401 GGGATGAAAC ACAAACTCCG CCTCCATGAA ACTGATGTTC TAAAGGGGAG ACAGATCACA ATCAGATCCA TAAGGAAAAG 002480
002481 TGTGTCTGTG TGTATCTTCC TCTCTAGGGA AAAATACAGC AGGGTGAGGG GATTGAGTGG GAGTGCAATC AGGGAAGACT 002560
002561 TCCTGAAGGC AGTGACTGGT GACTGGAATG AAGCATGAGA ATGAGCCATG CAGGTTGCCC AGAGAGAGCA TCCAGGCAGA 002640
002641 GGGAGCAGAA AGTTCCATCC TCACCCAGCT CTGCCGGCCC AGGTACTTTC TCCTCTGCCT TCTACTCCCA GTCTCACTGC 002720
002721 AGTGCAACAC ACTTCAGTTT TCTGGGAACT CCTGATGGAA AGTGGCTGTA TTTGTTCATC CCTATAGCCT TGGGGCACAG 002800
002801 CCAGCAGCCC CTGGAGGAAG CCCCGCAGGT GGGTAAAGAG ACACAGGGCT CCCAGCCGGC CCTGCCTCAC CTCTGCGCCG 002880
002881 GTGGCCCATC CATGATGATG TTGATCCATA GGATCTGCAT GGCGTTGAGG GGGCTGGGCA GGTTGAACAC GGTGGACAGA 002960
002961 GTGATGAGAC TCAGGGCGGA GATGCTCCTG CGGGGCAC
Labs working on this lncRNA
- Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
References
- ↑ 1.0 1.1 1.2 Li D, Zhang J, Wang M, Li X, Gong H, Tang H, Chen L, Wan L, Liu Q. Activity dependent LoNA regulates translation by coordinating rRNA transcription and methylation. Nat Commun. 2018 Apr 30;9(1):1726. doi: 10.1038/s41467-018-04072-4.
- ↑ Miao YY, Liu J, Zhu J, Tao YL, Zhang JA, Luo D, Zhou BR. The Effect of Botulinum Toxin Type A on Expression Profiling of Long Noncoding RNAs in Human Dermal Fibroblasts. Biomed Res Int. 2017;2017:2957941. doi:10.1155/2017/2957941.
