HCG14
HCG14, HLA complex group 14 long non-protein coding gene that carries a novel celiac disease risk variant.
Contents
Annotated Information
Name
Approved symbol：HCG14
Approved name：HLA complex group 14
HGNC ID ：HGNC:18323
Previous name：HLA complex group 14|HLA complex group 14 (non-protein coding)
Alias symbol：dJ111M5.4
RefSeq ID：NR_104117
Characteristics
HCG14 is a long non-protein coding RNA gene at chromosome location 6p22.1. A risk variant in HCG14 contributes to celiac disease pathogenesis.[1]
Function
This lncRNA seems to regulate the expression of NOD1 in an allele-specific manner.[1]
Regulation
Please input information here.
Expression
Expression of HCG14 was slightly downregulated in epithelial cells isolated from duodenal biopsies of celiac patients, and eQTL analysis revealed that polymorphisms in HCG14 region were associated with decreased NOD1 expression in duodenal intestinal cells.[1]
Disease
Celiac disease [1]
Labs working on this lncRNA
- Endocrinology and Diabetes Research Group, BioCruces Health Research Institute, UPV-EHU, CIBERDEM, Barakaldo.
- Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV-EHU), BioCruces Health Research Institute, Leioa.
- Department of Gastrointestinal and Liver Diseases, Biodonostia Health Research Institute, San Sebastian.
- Department of Pediatrics, University of the Basque Country (UPV-EHU), Cruces University Hospital, Barakaldo, Spain.
References
Sequence
>gi|414760|ref|NR_104117.1| Homo sapiens HLA complex group 14 (HCG14), long non-coding RNA
000081 TTTCAGGAAG GAAAGAAGAT CTTTTGCTTC TTCGGTCGCT GGGTCGGCTC TCCAGTGTCT GATGTTTACT GAAATCTTGA 000160
000161 TCGTGGTTAG CCTCCCCCAG GACTTCATTG TTTGGAAGAT GCCTTCGCCA AGCAATCTGA GCTCCAGGCC GGGAAGCCCC 000240
000241 AAGGTCACAA ATTTTAATGG AGCCCTGAAA CTAAACAGAA ATCATCCCTC CCACTAGAAC AAGAGCCCCT AGAGGCCAGC 000320
000321 GACACCGCTA AAATAACATG TGTAGACCAA TGCCGTCCAG GTAACAGTGC CTGGCAAACA CGGTAGAGGT TCAATAAATA 000400
000401 CATTTTAACT C
