HPYR1

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HPYR1, Helicobacter pylori responsive 1, a novel gene confirmed in vivo in patients with H. pylori infection presents a case of pathogen induced changes in host gene expression.

Annotated Information

Name

Approved symbol:HPYR1

Approved name:Helicobacter pylori responsive 1

HGNC ID:HGNC:16071

Previous name:Helicobacter pylori responsive 1|Helicobacter pylori responsive 1 (non-protein coding)

Alias symbol:;HPRG1|NCRNA00027|LINC00027

RefSeq ID:NR_026684

Characteristics

Please input information here.

Function

Gastric differential expression of a novel gene HPYR1 was confirmed in vivo in patients with H. pylori infection but functional mechanisms are not clear [1].

Diseases

  • H. pylori infection [1]

Expression

in vivo expression data shows that HPYR1 is upregulated at 0.75 h after exposure to cag PAI-positive strains [1].

Experiment Forward primer Reverse primer
RT PCR 5'-dGTAGGATCTTGTTTTGCTGC- 3' 5'-dCTACAGCTCTGTTGGTTACC- 3'[1]

Labs working on this lncRNA

  • Molecular Medicine Unit, St. James's University Hospital, Leeds LS9 7TF, United Kingdom. [1]
  • Genomics Unit, Glaxo Smith Kline Research and Development, Stevenage, Hertfordshire SG1 2NY, United Kingdom. [1]

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Cox JM, Clayton CL, Tomita T, Wallace DM, Robinson PA, Crabtree JE. cDNA array analysis of cag pathogenicity island-associated Helicobacter pylori epithelial cell response genes. Infection and immunity. 2001, 69(11):6970-80.

Sequence

>gi|93668|ref|NR_026684.1| Helicobacter pylori responsive 1 (HPYR1), long non-coding RNA

000001 TCATTCTGGG AGCCGCAGAG AGAAAGGTAG GATCTTGTTT TGCTGCAGGC TGACCTTGTG AGGTTTAGGT TTAGGTGGGG 000080
000081 CCATCTGGAA GAGTAAGCTC TACCCCTTAG AACAGGGCAG GAGGAGGGGA GGACTCTTCC ATTCTGAGAT ACAAATAAAA 000160
000161 CCCACCTTAT ACCATGAACA TTATTTTCCA AAAAACCCTG ATTTGGACTC CATATGGCAG TCATATATAT TCTTTCTGGT 000240
000241 AACATAACTT TGCTTGGCCT CATTTCTTGT GAACAGTCGT GGTCTTATTT TGTTTAGAGA TTGTTCATGC AATAGCTGCC 000320
000321 TTGGGTAACC AACAGAGCTG TAGGACGTTG TCAGACAATG ACGCATTCTG TGCCCAATCT CTTCTCCTGA ATTCCCAGGA 000400
000401 TTCACCTCCA AGTTAGGAAG GCAGTGGTAT TTTTATTTAA GTAGCTACCC TATGCAAAGC CATATCTCTC CTTAGGACTC 000480
000481 AGCCAGTTTC CCCAGGTTCT GCTAAAGGCG TATTTTGGAA TTGTCACCAC ACTATCCTCT GAGCCACCAC TCTTCTCGGG 000560
000561 AGGTTAAAGT CTGTTCCTGG TACAGCTCTT GAAGCCAACC CCTGCACTCA TCAGGTTGAG TTCTCCCCCA AAAATGAGTT 000640
000641 AACAGAGCAG GTCTGAGGCT GCTATGCTTA GAAAGACCTG CAGGCATGGC CGTCATCTGG GAACTTGGAC TTGGGGAGGG 000720
000721 TTTCCACCTT CCCCAGAATT GATAAGCGTG GCTCACAGTA CCTAAACAGA CGATGTGGTA TATGTTGAAC TTCTGCTTTC 000800
000801 CCTTCTGGGA GTCTGGAATT TTGGTATGTG CCAGGTAGAG GCAGACAATA AAAGCCTTGG GCCCTGAGTC TCTAAGAAGT 000880
000881 ATTCCTGGTA GACAGCATTT AACACATGGC ATGACTTGTT GCTGGAAGAA TTGAATATAT GCCATGTGAC CCCATGGGGA 000960
000961 AAAGACTCTT GGGAGCTTTC CT
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