GRASLND
The novel lncRNA GRASLND (originally named RNF144A-AS1) as a regulator of mesenchymal stem cell (MSC) chondrogenesis.[1]. And The expressions of gender-associated lncRNAs-RNF144A-AS1 is negatively correlated with Braak stage of AD. [2].
Contents
Annotated Information
Name
Approved symbol:GRASLND
Approved name:glycosaminoglycan regulatory associated long non-coding RNA
HGNC ID :HGNC:30963
Previous name:RNF144A antisense RNA 1 (non-protein coding)|RNF144A antisense RNA 1
RefSeq ID:NR_033997
prev_symbol:RNF144A-AS1
Characteristics
GRASLND, a primate-specific lncRNA, is upregulated during MSC chondrogenesis and appears to act directly downstream of SOX9, but not TGF-β3. [1].
Function
The novel lncRNA GRASLND (originally named RNF144A-AS1) as a regulator of mesenchymal stem cell (MSC) chondrogenesis.
[1].
GRASLND has an important role in regulating stem cell chondrogenesis, as well as its therapeutic potential in the treatment of cartilage-related diseases, such as osteoarthritis.[2].
Regulation
The silencing of GRASLND resulted in lower accumulation of cartilage-like extracellular matrix, while GRASLND overexpression - either via transgene ectopic expression or by endogenous activation via CRISPR-dCas9-VP64 - significantly enhanced cartilage matrix production.[1].
Expression
The expressions of gender-associated lncRNAs-RNF144A-AS1 is negatively correlated with Braak stage of AD. [2]
Diseases
Alzheimer's disease (AD) [2]
Labs working on this lncRNA
- Core Laboratory, School of Medicine, Sichuan Provincial People's Hospital Affiliated to University of Electronic Science and Technology of China, Chengdu, People's Republic of China.[2]
- Department of Computer Science and Engineering, University of Nebraska-Lincoln, Lincoln, NE, USA.[2]
- Key Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan University, Chengdu, People's Republic of China. Electronic address: zj804@163.com.[2]
- Department of Computer Science and Engineering, University of Nebraska-Lincoln, Lincoln, NE, USA. Electronic address: jcui@unl.edu.[2]
- Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address: guoku.hu@unmc.edu.[2]
- Department of Orthopaedic Surgery, Washington University, St Louis, United States.[1]
- Shriners Hospitals for Children, St. Louis, United States.[1]
- Department of Cell Biology, Duke University, Durham, United States.[1]
- Center of Regenerative Medicine, Washington University, St Louis, United States.[1]
- Department of Biomedical Engineering, Vanderbilt University, Nashville, United States.[1]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Huynh NP, Gloss CC, Lorentz J, Tang R, Brunger JM, McAlinden A, Zhang B, Guilak F. Long non-coding RNA GRASLND enhances chondrogenesis via suppression of the interferon type II signaling pathway. Elife. 2020 Mar 23;9:e49558. doi: 10.7554/eLife.49558. PMID: 32202492; PMCID: PMC7202894.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Cao M, Li H, Zhao J, Cui J, Hu G. Identification of age- and gender-associated long noncoding RNAs in the human brain with Alzheimer's disease. Neurobiol Aging. 2019 Sep;81:116-126. doi: 10.1016/j.neurobiolaging.2019.05.023. Epub 2019 Jun 6. PMID: 31280115; PMCID: PMC6732230.
