LINC00637
LncRNA LINC00637 (HIF-1α inhibitor at translation level),an inhibitor of ATM activation,and HIF-1α form an autoregulatory feedback loop where HIF-1α destabilizes LINC00637 by inducing MiR-205, which directly targets LINC00637 for degradation.
Contents
Annotated Information
Name
Approved symbol：LINC00637 Approved name：long intergenic non-protein coding RNA 637
HGNC ID：HGNC:27069
Alias symbol：LINC00637
RefSeq ID：NR_038436
Characteristics
LINC00637 titrates away YB-1 from the 5'-UTR of HIF-1α mRNA via a high-stringency YB-1-binding motif.[1]
Function
LINC00637-HIF-1α axis as constituting an additional layer of regulation of angiogenesis and tumor growth, with potential implications for therapeutic targeting.[1]. HTTT has a potential roles in sensitizing cancers to genotoxic treatment.[2].
Regulation
LINC00637 inhibits HIF-1α expression, mainly by interfering with its translation.[1]
Expression
Restoration of the expression of LINC00637 in cancer cells inhibits angiogenesis and tumor growth in vivo in an HIF-1α-dependent manner.[1]
Diseases
colon cancer[1]
Labs working on this lncRNA
- School of Life Science and Technology, Harbin Institute of Technology, 150001, Harbin, Heilongjiang Province, China.[1]
- The Affiliated Tumor Hospital of Harbin Medical University, 150001, Harbin, Heilongjiang Province, China.[1]
- State Key Laboratory of Robotics and Systems, Harbin Institute of Technology, 2 Yikuang, 150001, Harbin, China.[1]
- School of Life Science and Technology, Harbin Institute of Technology, 150001, Harbin, Heilongjiang Province, China. huying@hit.edu.cn.[1]
- Shenzhen Graduate School of Harbin Institute of Technology, 518055, Shenzhen, China. huying@hit.edu.cn.[1]
- School of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang Province, China.[2]
- The fourth affiliated hospital, Harbin Medical University, Harbin, Heilongjiang Province, China.[2]
- Shenzhen Graduate School of Harbin Institute of Technology, Shenzhen, China.[2]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Wang X, Li L, Zhao K, Lin Q, Li H, Xue X, Ge W, He H, Liu D, Xie H, Wu Q, Hu Y. A novel LncRNA LINC00637 forms a regulatory loop with HIF-1α to modulate angiogenesis and tumor growth. Cell Death Differ. 2020 Apr;27(4):1431-1446. doi: 10.1038/s41418-019-0449-8. Epub 2019 Nov 7. PMID: 31700144; PMCID: PMC7205893.
- ↑ 2.0 2.1 2.2 2.3 Zhao K, Wang X, Xue X, Li L, Hu Y. A long noncoding RNA sensitizes genotoxic treatment by attenuating ATM activation and homologous recombination repair in cancers. PLoS Biol. 2020 Mar 23;18(3):e3000666. doi: 10.1371/journal.pbio.3000666. PMID: 32203529; PMCID: PMC7138317.
