LNCNEF

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LNCNEF, is a long noncoding RNA and attenuated in vivo lung metastasis.

Annotated Information

Name

Approved symbol:LNCNEF

Approved name:lncRNA neighboring enhancer of FOXA2

HGNC ID HGNC:50656

Previous name:long intergenic non-protein coding RNA 1384

Alias symbol:lncRNA-NEF

RefSeq ID:NR_109883

Prev_symbol:LINC01384

Characteristics

LNCNEF is three exon transcript of 675 bp long non-coding RNA (GenBank), located on chromosome 20p11.21.

Function

Reinforced expression of LNCNEF suppressed in vivo tumor metastasis but not tumor growth. . a The indicated cells were implanted subcutaneously into nude mice. The tumor tissues were collected (n = 6). b Tumor weight was measured. c Tumor volumes were calculated after measurement. d The indicated cells were introduced into mice through tail vein injection (n = 6). The lung tissues were collected in the indicated time. e After H&E staining, representative pictures of lung tissues were captured. f The metastatic sites under the microscope were counted and calculated. **P < 0.01[1]

LNCNEF acted as a novel activator of its neighbor gene FOXA2, which formed a positive feedback loop [1].

LNCNEF physically interacted with β-catenin to increase the binding of GSK3β with β-catenin and therefore promoted the inhibitory phosphorylation of β-catenin, leading to the suppression on Wnt/β-catenin signaling and activation of FOXA2 expression [1].

Expression

LNCNEF is downregulated in human hepatocellular carcinoma (HCC) tissue [1].

Regulation

LNCNEF is transcriptionally activated by EMT suppressor FOXA2 [1].

Diseases

  • Hepatocellular carcinoma (HCC) [1]

Labs working on this lncRNA

  • School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, PR China.[1]
  • The Nethersole School of Nursing, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, PR China.[1]
  • School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, PR China.[1]
  • Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, PR China.[1]
  • Key Laboratory of Orthopaedics and Traumatology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, The First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, PR China.[1]

References

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 Liang W-C, Ren J-L, Wong C-W, Chan S-O, Waye MM-Y, Fu W-M et al. LncRNA-NEF antagonized epithelial to mesenchymal transition and cancer metastasis via cis-regulating FOXA2 and inactivating Wnt/β-catenin signaling[J]. Oncogene. 2018, 37(11):1445.

Sequence

>gi|101929685|ref|NR_109883.1| Homo sapiens lncRNA neighboring enhancer of FOXA2 (LNCNEF), long non-coding RNA

000001 ATGAAGAAAC AGAGGGATAT ACTGCCGTCT TAAACCAACC CAAATGCCTC TGCCGCAGTC GCAGTTATTT AGGGTGGAGA 000080
000081 AGCGGGCTCT GGCAACTAGA GAAGGTGGCC GCAGCATGGG GACACCCGAA TTGAGGAGCT GTTTGGGCAA TAAGCTGATT 000160
000161 TAGAGAATTA AGACCTCCAC AGATGGGAGT GGAATCCGCA ACTGCTCAAT CCATCCACTG AGAAGTCCCA TAAAAGATGG 000240
000241 ACAATCCATA ACTGAAACCC AACCTTCGGC ACAACGATCA AATTCTACAT GCATAAAGCA AGAGATCTGT GTGCCAGATC 000320
000321 CATCTTAAAG GCACCCCACC CAGAGGACAG AGTCTGTCTC CTTCCCCTAA ACAATATGCA GAAACCACCC TGGTATTTCA 000400
000401 TGGGTTCTCA CTTAGGAAAA TTGAGTTCTG TTCAATGATG CCCCTTCTGC ACTGGTTGGT TTCATGTGAC AAAGAGAGCT 000480
000481 CTAGGGAGGA CTTTTGCTAG GGGAACGCAG ATTGTTCCAG CAAGATGAAG GCCTAGGAGA CCTGGATGGC CTGGGTGTTT 000560
000561 TCTTCCCAGG GAGAGCAGAG GAGGCCTGGA TTTGAACTCG AGTCTTATGA CTTTGCCATT GAGGCAACAT CCAAAATAAA 000640
000641 AATAGCATGC TAACCCCAAA AAAAAAAAAA AAAAA
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