MIR23AHG
LOC284454 affected the cytoskeletal and adhesion-related Rho/Rac signaling pathways and is expected to be a new diagnostic and prognostic marker in patients with NPC.[1]
Contents
Annotated Information
Name
Approved symbol:MIR23AHG
Approved name:miR-23a/27a/24-2 cluster host gene
HGNC ID:HGNC:27620
Alias symbol:LOC284454
RefSeq ID:NR_036515
Characteristics
MIR23AHG located in the same primary transcript harboring miR-23a 27a 24-2 cluster is a stable, nuclear restricted and chromatin associated lncRNA.[2]
Function
Focal adhesion and cell migration pathway genes are downregulated under overexpression condition, and these genes are significantly upregulated in breast cancer cell lines as well as breast cancer tissue samples suggesting a functional role of MIR23AHG in breast cancer pathobiology.[2] In in vivo and in vitro assays, MIR23AHG promoted the migration and invasion capacity of NPC cells.[1]
Regulation
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Expression
Expression of MIR23AHG is significantly reduced in breast, prostate, uterus and kidney cancer and also in breast cancer cell lines (MCF7 and T47D). [2] MIR23AHG, was upregulated and associated with poor prognosis in NPC. [1]
Diseases
Breast cancer[2] Nasopharyngeal carcinoma (NPC)[1]
Labs working on this lncRNA
- Molecular Biology and Genetics Unit , Jawaharlal Nehru Centre for Advance Scientific Research , Bangalore , Karnataka , India.[2]
- Molecular Reproduction, Development and Genetics , Indian Institute of Science , Bangalore , Karnataka , India.[2]
- Kidwai Memorial Institute of Oncology , Bangalore , Karnataka , India.[2]
- The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital.[1]
- The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute and School of Basic Medical Science.[1]
- Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine.[1]
- Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.[1]
- Department of Chemistry, University of North Dakota, Grand Forks, ND, USA.[1]
- Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.[1]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Fan C, Tang Y, Wang J, Wang Y, Xiong F, Zhang S, Li X, Xiang B, Wu X, Guo C, Ma J, Zhou M, Li X, Xiong W, Li Y, Li G, Zeng Z. Long non-coding RNA LOC284454 promotes migration and invasion of nasopharyngeal carcinoma via modulating the Rho/Rac signaling pathway. Carcinogenesis. 2019 Apr 29;40(2):380-391. doi: 10.1093/carcin/bgy143.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Das M, Renganathan A, Dighe SN, Bhaduri U, Shettar A, Mukherjee G, Kondaiah P, Satyanarayana Rao MR. DDX5/p68 associated lncRNA LOC284454 is differentially expressed in human cancers and modulates gene expression. RNA Biol. 2018 Feb 1;15(2):214-230. doi: 10.1080/15476286.2017.1397261. Epub 2017 Dec 11.
