PCSEAT

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PCSEAT promoting cell proliferation and motility and a potential oncogene in PCa cells via mediating EZH2 activity.[1][2]

Annotated Information

Name

Approved symbol:PCSEAT

Approved name:prostate cancer expressed EZH2 associated transcript

HGNC ID HGNC:54485

Alias symbol:PRCAT38

RefSeq ID:NR_164474

Characteristics

PCSEAT in human prostate cancer tissues.[2]

Function

PCSEAT is specifically overexpressed in PCa patients and a potential oncogene in PCa cells via mediating EZH2 activity.[1]

Regulation

PCSEAT promotes cell proliferation by affecting miR-143-3p- and miR-24-2-5p-mediated regulation of EZH2, suggesting that PCSEAT and EZH2 competitively 'sponge' miR-143-3p and miR-24-2-5p.[1]

Expression

File:PCSEAT.jpeg
PCSEAT regulates EZH2 through miR-143-3p and 31 miR-24-2-5p.[1]

The expression levels of PCSEAT were significantly upregulated in human prostate cancer tissues.[2] Bioactive PCSEAT is incorporated into exosomes and transmitted to adjacent cells, thus promoting cell proliferation and motility.[1]

Diseases

Prostate cancer[2]

Labs working on this lncRNA

  • Faculty of Biological Sciences, Department of Genetics, Tarbiat Modares University, Tehran, Iran.[2]
  • Urology and Nephrology Research Centre, Labbafi-Nejad Medical Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran.[2]
  • Laboratory for Noncoding RNA & Cancer, School of Life Sciences, Shanghai University, Shanghai, 200444, China; CAS Key Laboratory of Bio-medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, 215163, China.[1]
  • CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.[1]
  • CAS Key Laboratory of Bio-medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, 215163, China.[1]
  • Shanxi Academy of Advanced Research and Innovation, Taiyuan, 030032, China.[1]
  • Medical College, Guizhou University, Guiyang, 550025, China.[1]
  • CAS Key Laboratory of Bio-medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, 215163, China; Shanxi Academy of Advanced Research and Innovation, Taiyuan, 030032, China; Medical College, Guizhou University, Guiyang, 550025, China. Electronic address: gaos@sibet.ac.cn.[1]

References

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 Yang X, Wang L, Li R, Zhao Y, Gu Y, Liu S, Cheng T, Huang K, Yuan Y, Song D, Gao S. The long non-coding RNA PCSEAT exhibits an oncogenic property in prostate cancer and functions as a competing endogenous RNA that associates with EZH2. Biochem Biophys Res Commun. 2018 Jul 12;502(2):262-268. doi:10.1016/j.bbrc.2018.05.157. Epub 2018 May 26.
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Bayat H, Narouie B, Ziaee SM, Mowla SJ. Two long non-coding RNAs, Prcat17.3 and Prcat38, could efficiently discriminate benign prostate hyperplasia from prostate cancer. Prostate. 2018 Aug;78(11):812-818. doi: 10.1002/pros.23538. Epub 2018 Apr 19.