CHROMR

A primate-specific lncRNA ( CHROME ), elevated in the plasma and atherosclerotic plaques of individuals with coronary artery disease, that regulates cellular and systemic cholesterol homeostasis.

Annotated Information

Name

Approved symbol:CHROMR

Approved name:cholesterol induced regulator of metabolism RNA

HGNC ID:54059

Previous name:PRKRA antisense RNA 1

Alias symbol:CHROME

prev_symbol:PRKRA-AS1

RefSeq ID:NR_110204

prev_symbol:PRKRA-AS1

Characteristics

A primate-specific lncRNA, increased in the setting of human atherosclerotic vascular disease, that contributes to the maintenance of cholesterol homeostasis.

Function

CHROME as a central component of the non-coding RNA circuitry controlling cholesterol homeostasis in humans.<ref name="ref1">.

Regulation

CHROME promotes cholesterol efflux and HDL biogenesis by curbing the actions of a set of functionally related microRNAs that repress genes in those pathways<ref name="ref1">.

Expression

LncRNA CHROME expression is influenced by dietary and cellular cholesterol via the sterol-activated liver X receptor transcription factors, which control genes mediating responses to cholesterol overload.<ref name="ref1">.

Disease

• systemic cholesterol homeostasis<ref name="ref1">.

Labs working on this lncRNA

• Department of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA<ref name="ref1">.

• Department of Internal Medicine (Nephrology), Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands<ref name="ref1">.

• Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California, USA<ref name="ref1">.

• Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden<ref name="ref1">.

• Department of Vascular and Endovascular Surgery, Klinikum Rechts der Isar, Technical University Munich, Munich, Germany<ref name="ref1">.

• Max Planck Institute for Molecular Genetics, Berlin, Germany<ref name="ref1">.

• Department of Microbiology, New York University School of Medicine, New York, New York, USA<ref name="ref1">.

• INSERM U1111, Centre International de Recherche en Infectiologie, Ecole Normale Supérieure de Lyon, Université de Lyon, Lyon, France<ref name="ref1">.

• Saha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky, USA<ref name="ref1">.

• Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenessee, USA<ref name="ref1">.

• Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University Ithaca, New York, USA<ref name="ref1">.

• Institute of Laboratory Medicine, Ludwig-Maximilians-University Munich, Munich, Germany<ref name="ref1">.

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