DCXR-DT
DCXR-DT, A long non-coding RNA that shows potent activity in prostate cancer.
Contents
Annotated Information
Name
Approved symbol:DCXR-DT
Approved name:DCXR divergent transcript
HGNC ID:54083
Alias symbol:RP13-650J16.1
RefSeq ID:NR_159947
Characteristics
DCXR-DT belongs to the class of noncoding RNA, and is located adjacent to RAC3 on chromosome 17q25.3 [1]. DCXR-DT act as an oncogene. DCXR-DT
Function
DCXR-DT regulates the expression of RAC3 genes. [1] DCXR-DT might be an oncogene and plays role in cell proliferation. [1] Knockout of DCXR-DT could inhibit PCa cell proliferation and migration. [1]
Regulation
NA
Diseases
- Prostate Cancer [1]
Expression
Expressions of DCXR-DT and RAC3 in PCa tissues were higher than that in paracancerous tissues. [1] Effect of DCXR-DT on downstream gene was studied, DU145 cells were transfected with si-RP13-650J16.1. This results showed that si-RP13-650J16.1 could significantly reduce RAC3 expression and BCL-2 protein level. [1]
Labs working on this lncRNA
- Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China
- Department of Urology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
- Department of Urology, Yichun People’s Hospital, Yichun 336000, Jiangxi, China
References
Sequence
>gi|113523640|ref|NR_159947.1|Homo sapiens DCXR divergent transcript (DCXR-DT), transcript variant 1, long non-coding RNA
000081 AATATCGGAA AGAATGTGTG GTTAATATCA GGAAGAACAC GTGAAATGGA GAATTTCAGG GCTAACATTT CTTGTTTTGT 000160
000161 TTCTGAAAAC ATCGGCATGT CCTAAAAAGT GTCGCCTGTG CCCATCATCT CTCAGGCTTG GGAGCAGGAC ACCGCCGGCT 000240
000241 CACTTTAAAG CCAAGGGAAA GAATTTGGAC AACCAACTAC GTCTGGAGAA GACACCAATG TCAGCAGAGC TCCGCTTTCA 000320
000321 TCTGTGGGCG AAGGATTACC TAGATGCCAA GGCAAGAGAC TGAAGACACA AACTGTTTCA GTATAACAAA GAAAATAGGC 000400
000401 CGGGAGCGGT GGCTCACGCC TGTAATCCCA GCACTTTGGG AGGCCGAGGC GGGTGGATCA CGAGGTCAGG AGATCGAGAC 000480
000481 CATCCTGGCT AACACGCTAC CTAAAAGGGA AGCGCCCCCT GTCCTATGAT CACGTGACTT GCTTCACCTT GTCAATCACT 000560
000561 TGGAAGATTC ACCCTCCTTA CCCTGCCCTC CTTGTCTTGT ATGCAATAAA TATCAGTGCG CCCAGCCATT CGGGGCCACT 000640
000641 ACTGGTCTCC GTGTCTTGAT GGTAGTGGTC CCCCGGGCCC AGCTGTTCTC TCTTTA
