FAM99A
The alterations in the lncRNA family with sequence similarity 99 member A (FAM99A) in PE and its effects on trophoblasts.
Contents
Annotated Information
Name
Approved symbol:FAM99A
Approved name:family with sequence similarity 99 member A
HGNC ID:HGNC:32368
Previous name:family with sequence similarity 99, member A|family with sequence similarity 99, member A (non-protein coding)|family with sequence similarity 99 member A (non-protein coding)
Alias symbol:FLJ42833
RefSeq ID:NR_026643
LncBook ID:[1]
Characteristics
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Function
FAM99A may serve a role in modulating the functions of trophoblasts, partially via targeting Wnt/β catenin signaling. [1].
EMS cooperates with the RNA binding protein RALY to stabilize E2F1 mRNA, and thereby increases E2F1 expression[1].
Regulation
Overexpression of FAM99A promoted invasion and migration of HTR 8/SVneo cells; conversely, knockdown of FAM99A suppressed the invasive and migratory abilities of HTR 8/SVneo cells.[1].
Expression
FAM99A overexpression induced a decrease in the apoptotic rate of cells, whereas knockdown of FAM99A increased the apoptotic rate of HTR 8/SVneo cells. [1].
Diseases
- Preeclampsia (PE)[1].
Labs working on this lncRNA
- Obstetrics and Gynecology Intensive Care Unit, The Northwest Women and Children's Hospital, Xi'an, Shaanxi 718900, P.R. China.[1]
- Department of Obstetrics, The Northwest Women and Children's Hospital, Xi'an, Shaanxi 718900, P.R. China.[1]
