LINC02859

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LINC02859,a long non-coding RNA, function as anti-oncogene and also plays an important role in GC tumorigenesis.[1]

Annotated Information

Name

Approved symbol:LINC02859

HGNC ID:54399

Approved name:long intergenic non-protein coding RNA 2859

Alias symbol:LncRNA-LOC101928316

RefSeq ID:XR_001748478

Characteristics

location:11p15.2

Function

LINC02859 overexpression can significantly inhibit SGC-7901 cell migration, invasion, and proliferation (P<0.05).[1]

Regulation

LINC02859 can regulate PI3K-Akt-mTOR signaling pathway and change the GC development progression in vivo and in vitro.[1]

Expression

LINC02859 overexpression can inhibit the GC tumorigenesis in vivo.[1]

LINC02859 was significantly downregulated in gastric cancer (GC) tissues specimen, GC cell lines, and associated with the GC patients tumor, node, and metastasis (TNM) stage and degree of differentiation (P < 0.05).[1] LINC02859 overexpression can inhibit the GC tumorigenesis in vivo.[1]

Diseases

Gastric cancer (GC) [1]

Labs working on this lncRNA

  • Department of Toxicology, School of Public Health, Lanzhou University, Lanzhou, China.[1]
  • Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China.[1]
  • Gansu Wuwei Tumor Hospital, Wuwei, China.[1]
  • Department of Oncology, Jiangsu Cancer Hospital, Nanjing, China.[1]

References

  1. Jump up to: 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 Li C, Liang G, Yang S, Sui J, Wu W, Xu S, Ye Y, Shen B, Zhang X, Zhang Y. LncRNA-LOC101928316 contributes to gastric cancer progression through regulating PI3K-Akt-mTOR signaling pathway. Cancer Med. 2019 Aug;8(9):4428-4440. doi: 10.1002/cam4.2165. Epub 2019 Jun 17. PMID: 31207155; PMCID: PMC6675725.