LINC02835
LINC02835,an LTR-activated long noncoding RNA, modulates cell migration and invasion via posttranslational control of p120-catenin protein stability. [1]
Contents
Annotated Information
Name
Approved symbol:LINC02835
HGNC ID:54369
Approved name:long intergenic non-protein coding RNA 2835
Alias symbol:lncMER52A
RefSeq ID:XR_002959796
Characteristics
LINC02835 derived from MER52A retrotransposons that was exclusively expressed in hepatocellular carcinoma (HCC).[1]
Function
LINC02835 blocks ubiquitin/proteasome-dependent p120-catenin degradation.[1] LINC02835 promoted invasion and metastasis of HCC cells in vitro and in vivo.[1]
Regulation
The activation of LINC02835 is tightly regulated by chromatin 516 accessibility and transcription factors YY1.[1] LINC02835 stabilized p120-catenin and triggered the activation of Rho GTPase downstream of p120-catenin.[1] LINC02835 regulates the Epithelial-Mesenchymal Transition (EMT) signaling pathway.[1]
Expression
LINC02835(liver cancer-specific oncogenic long non-coding RNA transcribed by MER52A LTR retrotransposon of the ERV1 class) that is not expressed in most normal tissues but is widely expressed in HCC samples.[1]
Diseases
Hepatocellular carcinoma (HCC)[1]
Labs working on this lncRNA
- Fudan University Shanghai Cancer Center, Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.[1]
- Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.[1]
References
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 Wu Y, Zhao Y, Huan L, Zhao J, Zhou Y, Xu L, Hu Z, Liu Y, Chen Z, Wang L, Huang S, He X, Liang L. An LTR Retrotransposon-Derived Long Noncoding RNA lncMER52A Promotes Hepatocellular Carcinoma Progression by Binding p120-Catenin. Cancer Res. 2020 Mar 1;80(5):976-987. doi: 10.1158/0008-5472.CAN-19-2115. Epub 2019 Dec 24. PMID: 31874857.
