LINC02861
LINC02861,a long noncoding RNA,regulates IQSEC. 2 expression by sponging miR-744-5p.[1]
Contents
Annotated Information
Name
Approved symbol：LINC02861
HGNC ID:54406
Approved name：long intergenic non-protein coding RNA 2861
Alias symbol：RP11-462G12.2
RefSeq ID：NR_120311
Characteristics
Rs2262251 (G>C) in LINC02861 is in high linkage disequilibrium with rs8049367 and is a potential causative single-nucleotide polymorphism (SNP) for NSCL/P.[1]
Function
Rs2262251 in lncRNA LINC02861 is associated with nonsyndromic cleft lip with/without cleft palate.[1]
Regulation
LINC02861 regulates IQSEC. 2 expression by sponging miR-744-5p.[1] LINC02861 rs2262251 [C] is a target of miR-744-5p.[1]
Expression
Knockdown of lncRNA LINC02861 induced a significant increased in the number of G0/G1 phase cells and reduction the number of S phase cells. [1]
Diseases
Nonsyndromic cleft lip with/without cleft palate (NSCL/P) [1]
Labs working on this lncRNA
- Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.[1]
- Department of Orthodontics, College of Stomatology, Dalian Medical University, Dalian, China.[1]
- Department of Environmental Genomics, School of Public Health, Nanjing Medical University, Nanjing, China.[1]
- State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China.[1]
References
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 Yun L, Ma L, Wang M, Yang F, Kan S, Zhang C, Xu M, Li D, Du Y, Zhang W, Pan Y, Wang L. Rs2262251 in lncRNA RP11-462G12.2 is associated with nonsyndromic cleft lip with/without cleft palate. Hum Mutat. 2019 Nov;40(11):2057-2067. doi: 10.1002/humu.23859. Epub 2019 Aug 7. PMID: 31283072.
