THY1-AS1
THY1-AS1,a dysregulated long noncoding RNA (lncRNA) long noncoding, promotes the proliferation, migration and invasion of breast cancer cells by activating the STAT3 pathway.[1]
Contents
Annotated Information
Name
Approved symbol：THY1-AS1
Approved name：THY1 antisense RNA 1
HGNC ID：54852
Alias symbol：RP11-334E6.12
Characteristics
THY1-AS1 is related to poor overall survival.[1]
Function
THY1-AS1 promoted the proliferation, migration and invasion of BC cells.[1]
Regulation
THY1-AS1 promotes the phosphorylation of STAT3 pathway.[1]
THY1-AS1 promotes the epithelial mesenchymal transition of BC by activating the STAT3 pathway. [1]
Expression
THY1-AS1 is upregulated in the TCGA database.[1]
Disease
Breast cancer[1]
Labs working on this lncRNA=
- Department of General Surgery, Chiping District People's Hospital, Liaocheng, Shandong, People's Republic of China.[1]
- Department of Anesthesiology, Chiping District People's Hospital, Liaocheng, Shandong, People's Republic of China.[1]
- Department of Thyroid and Breast Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, People's Republic of China.[1]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Sun D, Liu H, Wang T. Long Noncoding RNA RP11-334E6.12 Promotes the Proliferation, Migration and Invasion of Breast Cancer Cells Through the EMT Pathway by Activating the STAT3 Cascade. Cancer Manag Res. 2020 Feb 13;12:1113-1120. doi: 10.2147/CMAR.S237981. PMID: 32104091; PMCID: PMC7025680.
