WAKMAR2
WAKMAR2, a Long Noncoding RNA Downregulated in Human Chronic Wounds, is an important regulator of skin wound healing.[1]
Contents
Annotated Information
Name
Approved symbol：WAKMAR2
Approved name：wound and keratinocyte migration associated lncRNA 2
HGNC ID：53754
Alias symbol：lnc-TNFAIP3
RefSeq ID：NR_049793
Characteristics
In both cytoplasm and nucleus.[1]
Function
WAKMAR2 is an important regulator of skin wound healing and its deficiency contribute to the pathogenesis of chronic wounds.[1][2] WAKMAR2 restricte the production of inflammatory chemokines by keratinocytes, while enhancing cell migration.[1] WAKMAR2 modulates Keratinocyte Motility and Production of Inflammatory Chemokines.[1]
Regulation
WAKMAR2 expression is induced by TGF-β signaling.[1]
Expression
Knockdown of WAKMAR2 impaire re-epithelization of human ex vivo wounds.[1]
Disease
Pathophysiological inflammation.[2]
Labs working on this lncRNA=
- Dermatology and Venereology Section, Department of Medicine (Solna), Karolinska Institute, Stockholm, Sweden.[1]
- Department of Dermatology, The Second Hospital of Dalian Medical University, Dalian, China.[1]
- Department of Wound Regeneration, The Second Hospital of Dalian Medical University, Dalian, China.[1]
- Department of Molecular Medicine and Surgery, Section of Plastic Surgery, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden.[1]
- Department of Medicine Huddinge, Karolinska Institute, Stockholm, Sweden.[1]
- Department of Immunology, Genetics and Pathology, Section of Clinical Immunology, Uppsala University, Sweden.[1]
- Dermato-Venereology Clinic, Karolinska University Hospital, Stockholm, Sweden. [1]
Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA, USA.[2]
- Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.[2]
- Center for Infectious Disease Research (CIDR), Seattle, WA, USA.[2]
- Department of Immunology, University of Washington School of Medicine, Seattle, WA, USA.[2]
- Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego School of Medicine, La Jolla, CA, USA.[2]
References
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 Herter EK, Li D, Toma MA, Vij M, Li X, Visscher D, Wang A, Chu T, Sommar P, Blomqvist L, Berglund D, Ståhle M, Wikstrom JD, Xu Landén N. WAKMAR2, a Long Noncoding RNA Downregulated in Human Chronic Wounds, Modulates Keratinocyte Motility and Production of Inflammatory Chemokines. J Invest Dermatol. 2019 Jun;139(6):1373-1384. doi: 10.1016/j.jid.2018.11.033. Epub 2018 Dec 27. PMID: 30594489.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Zhang Q, Chao TC, Patil VS, Qin Y, Tiwari SK, Chiou J, Dobin A, Tsai CM, Li Z, Dang J, Gupta S, Urdahl K, Nizet V, Gingeras TR, Gaulton KJ, Rana TM. The long noncoding RNA ROCKI regulates inflammatory gene expression. EMBO J. 2019 Apr 15;38(8):e100041. doi: 10.15252/embj.2018100041. Epub 2019 Mar 27. PMID: 30918008; PMCID: PMC6463213.
