AIRN
The AIRN ,the master regulator of imprinted expression in the Igf2r imprinted gene cluster, splices suppression and termination silencing activity.[1]
Contents
Annotated Information
Name
Approved symbol:AIRN
Approved name:antisense of IGF2R non-protein coding RNA
HGNC ID:34515
Previous name:antisense of IGF2R RNA (non-protein coding)
Alias symbol:AIR|NCRNA00088|IGF2RAS|IGF2R-AS1
RefSeq ID:NR_047511
LncBook ID:HSALNG0054798
Characteristics
The AIRN transcript is 108 kb long, predominantly unspliced and nuclear localized, with only a minority being variably spliced and exported.[1] Mouse Igf2r imprinted expression is controlled by the AIRN whose promoter lies in an intronic maternally-methylated CpG island. [2]
Function
AIRN expression not only induces silencing of flanking mRNA genes but also protects the paternal copy of the ICE from de novo methylation.[1]
Expression
DNA methylation of the maternal imprint control element (ICE) restricts AIRN expression to the paternal allele. [1]
Labs working on this lncRNA
- Ce-M-M-Research Center for Molecular Medicine of the Austrian Academy of Science, Vienna Biocenter, Dr. Bohr-Gasse 9/4, A1030 Vienna, Austria.[2] [1]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Stricker SH, Steenpass L, Pauler FM, Santoro F, Latos PA, Huang R, Koerner MV, Sloane MA, Warczok KE, Barlow DP. Silencing and transcriptional properties of the imprinted Airn ncRNA are independent of the endogenous promoter. EMBO J. 2008 Dec 3;27(23):3116-28. doi: 10.1038/emboj.2008.239. Epub 2008 Nov 13. PMID: 19008856; PMCID: PMC2599881.
- ↑ 2.0 2.1 Yotova IY, Vlatkovic IM, Pauler FM, Warczok KE, Ambros PF, Oshimura M, Theussl HC, Gessler M, Wagner EF, Barlow DP. Identification of the human homolog of the imprinted mouse Air non-coding RNA. Genomics. 2008 Dec;92(6):464-73. doi: 10.1016/j.ygeno.2008.08.004. Epub 2008 Oct 2. PMID: 18789384; PMCID: PMC2846268.
