ASB16-AS1
ASB16-AS1,as a miR-760 Sponge，facilitates the Malignant Phenotype of Osteosarcoma by Increasing HDGF Expression.[1]
Contents
Annotated Information
Name
Approved symbol：ASB16-AS1
Approved name:ASB16 antisense RNA 1
HGNC ID ：25442
Previous name:chromosome 17 open reading frame 65
Alias symbol:DKFZp762C2414
RefSeq ID：NR_049729
Characteristics
HCG14 is a long non-protein coding RNA gene at chromosome location 17q21.31.[1]
Function
ASB16-AS1 increased HDGF expression by sponging miR-760, thereby conferring cancer-promoting roles in OS. ASB16-AS1 is a potential early diagnostic and therapeutic target in OS.[1]
Regulation
ASB16-AS1 served as a sponge for miR-760 and positively modulated the expression of its target HDGF. [1]
Expression
ASB16-AS1 expression was significantly elevated in OS tissues and cell lines.[1]
Disease
Osteosarcoma [1]
Labs working on this lncRNA
- Department of Orthopedics, China-Japan Union Hospital Jilin University, Changchun, Jilin 130033, People's Republic of China.[1]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Yin R, Liu J, Zhao D, Wang F. Long Non-Coding RNA ASB16-AS1 Functions as a miR-760 Sponge to Facilitate the Malignant Phenotype of Osteosarcoma by Increasing HDGF Expression. Onco Targets Ther. 2020 Mar 13;13:2261-2274. doi: 10.2147/OTT.S240022. PMID: 32214826; PMCID: PMC7081065.
