ENST00000500949.2

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Annotated Information

Name

cyrano

Characteristics

Has similar structural characteristics in different vertebrate species. Spliced transcript with long (4-8kb) terminal exon which contains a number of conserved sequences.

Zebrafish: ~4.5kb, 3 exons with long terminal exon. Terminal exon contain several DNA transposons. Convergent transcription with oip5.

Human: ~8.8kb transcript has positional synteny, generally 3 or 4 exons, full length transcript has a long terminal exon.

Mouse: ~8.2kb, transcript has positional synteny, 3 exons, full length transcript has a long terminal exon.

Transcriptomic Nomeclature

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Function

• Required for normal embronyic development in Zebrafish. Morpholinos to decrease transcript level or block conserved (miR-7 recognition) site had neural development defects and short tails.

- Lack of functional cyrano caused small heads and eyes, “defect in neural tube opening, loss of NeuroD-positive cells in the retina and tectum and enlarged nasal placodes”.

• Defects could be recused by mature zebrafish cyrano transcript as well as the human and mouse orthologues.

• Conserved site was necessary but not sufficient to explain cyrano function in zebrafish.

Regulation

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Expression

Expressed in zebrafish nervous system. Brain and notochord at 24 hours post fertilization (hpf), expression at 72 hpf also includes zebrafish spinal cord. Mouse and human homolgoues are widely expressed in adult and developing tissues and cell lines including the brain (ENCODE, Gascoigne et al). RNA stability half-life of mouse homologue was 3-4 hr in neuroblastoma cells, close to lncRNA median (Clark (2012)).

Allelic Information and Variation

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Evolution

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Labs working on this lncRNA

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References

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Basic Information

Transcript ID	ENST00000500949.2
Source	Gencode19
Same with	lnc-AC012652.1.1-1:5
Classification	intergenic
Length	8829 nt
Genomic location	chr15+:41576203..41598732
Exon number	4
Exons	41576203..41576308,41577423..41577561,41578209..41578298,41590239..41598732
Genome context
Sequence	000001 GAGAAGCTGC GAAGATGGCG GAGTAAGGCG TGCCGCTGCA AACTGGCCTC TGGGCCGGGG GCGAGCAGCC CCCGGGAGGC 000080 000081 CGAGTGCATC TGTTGGACCG TGCGAGGAGA AGAAAAAAAA TATCGGCCAG AGGAGAGGAA CTAACCGAAC ATTCTTCCTC 000160 000161 CCTACCTTAT AGAGGGGAGT GGTCATCTAC ACTAAAGCAA AGTGTTAGGC GCGTCCGTGC GAAGAGACCA CCAAACAGGC 000240 000241 TTTGTGTTCC TTATCACAGG AAGAAAATTT TCCTTGACCT TTAGGTGCTT TTATATTCAT CTCAAAAACA AAATTCTGAA 000320 000321 CTCAGGACTT GGCAAGTGTC TCTATGTTGT CTCCTAGAGT GGGTAGTCCT GCTTCTTTTA CCCAGTTACT TTCCCGTTTT 000400 000401 TGAAATGTGG CTATCACTTC TCTACACATT ACCTCCATGA TTTGGAATGG AAAAGGCCAC TTTTCTTTTT GTTCTGCCTC 000480 000481 TCAAATTCAA CACAGAGGAG CTCCTAGGAT TCCAGTTATC CTGCTAACAT CTCCAGGAAG AAAGAAGCAA CTCACATGGG 000560 000561 TCTTTTGCTG TTTGCTTAAT TATAAAGACA TCATTTTGCA AGCAGAAGGC TGAGTTTCAT TTGAAACAGG TGCTTAGGTG 000640 000641 GTGGTATTTG TGAATACTTT TCATTCCAAG CAAGAAGACT AAAGAAGTAG CAAGTATGAA TGACTTCAGG GTTTAAAAAA 000720 000721 AATGTCTTCC AGTTTCAGCC ACTACCATGA TAAGCACAGT TGAGACTGCA GCAGTAAATT CCAAATATGT GTTTCTAATT 000800 000801 TGACGTGAAA GATACTAAAA ATTTATATTT GTATATTTAA ATCCTGGCTC ATCCTGTGAC ATAGATTTAC TGAATAGGAA 000880 000881 CAAAGGCCCA ATTTTAAACA AAAACCTAGG CCGGGTGTGG TGGCTCACAC CTGTAATCCC AACACTTTGG GAGGCCAAGG 000960 000961 CAGGCAAATC ACCTGAGGTT GGGAGTTTGA GACCAGCCTG ACCAACATGG AGAAACCCCA TCTCTACTAA AAATAGAAAA 001040 001041 TTAGCCAGGT GTGGTGGTAG ATACGTGTAA TCCCAGCTAC TCGTGAGGCT GAGGCAGGAG AATTGCTTGA ATCCGGGAGG 001120 001121 CGGAGGTTGC AGTGAACTGA GATTGCACCA CTGCACTCCA GCCTGGGCGA CAGAGTGAGA CTCCGTCTCA GAAAAATAAA 001200 001201 AAACAACTTT GGACATAGAG GAGTTGGGGG CAGAGGGGGG AGGATGAGAG AATTTTCCAT GTAACTCCTT TTCCTTAAGA 001280 001281 AAAAGAAGCA AAAATCCCTC ATGCAGTGCC ATCTGACTTT ATGGTGTTTC ACATTATATA GTTACTTTTT TTAATAAACG 001360 001361 CATAAGATTA ACTCTTCCTG CAACCCAAGG TGGATACTTG GATGTTTGAT TTTTATTTAT TTATTTATTT ATTTTTTGAG 001440 001441 GCAGTCTCTC TCTGTTGCCC AGGCTGGAGT GATGCGTGAT TTCTGCTCAC TGCAGTCTCT CCCACCCGGG TTCAAGCGAT 001520 001521 TCTCCTGCCT CAGCCTCCCA AGTAGCTAGG ATTACAGGCG CGCACCACCA CGCTCAGCCT GATTTCTAGG CTGAAAAGGC 001600 001601 TGGGACTCAG GTACTTTCCC CAGTTGGGAC TGAACTTTCT CATCAGAGAA TGGGCCTCAG AAGCAATGTT CCCAAACTTG 001680 001681 TGGTTGGGTC ATCGTGGAAA AGAAACCTCA AATAAGAAAA ATAATTACAA TAAGAAATGG ATTTTCTTTT TTCCCACAAC 001760 001761 AGTTATACAT TATAAAGAAC AGACTGTCGT AGAAAACTGT CTTTGCTTCC AAATCAGCAG AGGACCATTG TATGTATTGT 001840 001841 CAGGTCTTTA TATAAGAGTG AAACCTTTAT TTATGCTTCT TGTGAGTAGA GAATAAATTT TAAAACTAAT TAGATGAAAT 001920 001921 TAAGAACAGA GTATTGGAAC ATCTCTGTGT TTTCCGGAAT GTTTACTCAG GTCCATGAAT GCTGTGATGC TGGGAACTTA 002000 002001 GGGAAGATTC ACCAAAATTT GAGAGTGATA AAAATGGCCT AAAATGGGAA ATGGTGAGCA CTCTTATTAT TAGTGAGATT 002080 002081 GGTCAATCAG CCCATTTGAA ATGGGTAAAA AATACTTTCA GTAAAATAAT TACATATTAT ATATAAAATA TTTCTTTTTT 002160 002161 TGAGGGCAGC TACTGAGTGA TAAAAGCATA GTAGAAATCA CTTTGGTTAA AAGTAACTCA AATTTTTCTC TTAAGTAATC 002240 002241 TACCAACTTC CTGATGTTTT TCTTTAATAT TTTGGAACTG TTCAAGACAG AATGGAGCCT ACATATATGG TGTTCCACTA 002320 002321 GTATGTTGAA AATGTCATAT CATGGAGAAT GGAGACACCT TCCAGGTGTC TGTTAAACCC ATCTTCTCTG TGTACTTCTG 002400 002401 GCATCTTTTT TGGTAGGATC ATTTGGCAGG GGGTAGAGTA CCTGTACTTT TGGCACCATT GAAACCAGCT CTGGCCCACT 002480 002481 TGTTTGAATA GCTATCAGAC TCAGCGTCTC TATATGCTTT ATATACAGTT GAGAGAACCA GTGTTTAATG CTCTTGAAAT 002560 002561 TGTATCTTCC ATGCTTCAGA CCAGATGCAT TTAACAAAAT GGATATATTC CAGCTGTAGT TGCCCAGTGT TTACTTAACA 002640 002641 CATCTACATT TTTTTCTTGT CTATTTTGGT CCCCTTGATA GGAAAAGCTA TAATTTTAGG CAGGACTATA CGTCGATTTG 002720 002721 TAGCCATGCT TCCTTCCTTT CCCTTGCTCA TCCATGTTAG CTGGCAGTTT TTCTTTTGAA AAGTTAAAAC CGGGATATGT 002800 002801 GCAATAGAAA TATATATATA TATATGTATA TTTTAATACT TGTGGACAAA TGTTACAAGT TGTTTAAGAA CAACAAAATC 002880 002881 ACCAATGTCT TCCATTTTGA GATGTGTATA GTTTTGTAAG CATTAGTGCT TGGTAGCATA TTGTAGTGCC ATGTTAGGGG 002960 002961 TTAGTGCATG AGTCTAGTGA TTTTAAACTT CAGGATGAAT TATTGATAAT AACAAATAGT GTAAAAAGAG TGGAAAATCT 003040 003041 AAACCTTTTC TTTTTCCATA ATGTCTAAAT CTGTTATATT CTTCCTGGGG AAAAGAGATT AAGGCCCAAA AGACTCATTT 003120 003121 ATGAATAGAA ATGTGGGGTC AAAATCTGAG ATACTATATT TGAGGACATT TCAGCTTTCC ATAAGGTATC TGGAAACCAG 003200 003201 CTGTCTTTGT GTCTTATGAA ACCTCAAGTC AAAATGAGAC CGCATTTAAT TATTCTGCTT TGCTCTTTTT TTGGGGTGGG 003280 003281 GGGGAGATAG AGTTTCACTC TGTCACCCAG GCTGGAGTGC AGTGGCACAA TCTTTGCTCA CTGTAACCTC TGCCTCTTGG 003360 003361 GTTCAAGTGA TTCTCGTGCC CCAGCCTCCC GAGTAGCTGG GACTACAGGC ACGTGCCACC ACGCCCAGCT AATTTTTATA 003440 003441 TTTTTAGTAG AGACGGGGTT TTGCTGTGTT GGCCAGGCTG GTCTCAAACT CCTGACCTCA AGTAATCCAC CTGGCCTGCT 003520 003521 CTTTTCATGT CTTAACATGG CATGTCTTTT AGTTTCATTA TTTTCCTACT CCTTGTATGT CAAGAAATTA CATTTTGCAT 003600 003601 GTCTTATGGA GATGCTGTTA ATTGCTTCAG TGAGTGCTTT TCTAATCTGC AGACCATTTA CATTTCCTGT TTGCAGCATG 003680 003681 CTGTGTGCAA ACACTCAGTA ATTTGGAGTA TTCAATTATT TGTTAGGGCT CTTCCTATTT CCAAATGTGC TGAATTGTCT 003760 003761 ATTGATGGGA TTTTCAGATC TTTTCATGAG AACTGGAAAT GTAGCTGGGT GGCACCTACC TAGGTTGCTA CGTAGTGAGT 003840 003841 AGACTTTCTC TTGGGTATAG TAAGCCTCAG ACAGCTTTCA CTTTTATCTA CTTTACTTGT GGAAATAAAA CAGTCATTTT 003920 003921 GTTCTGAAAG AATAAGATAG CTTTCTGTAG AGAAGGAATT CCTACCTCTA AAAGCTGCCT TGAGAACTCA GAACTGGCAG 004000 004001 TTTTCTGAGG TGATTTTTAA ATTTCAGTAT TAGGGAGAGT CCAGCATTTG CTGACACAGA TTCTACATAA CTAATGTATG 004080 004081 ATAGCAAATG CAAAACTATT ATAATGTGGT GTATCTTGCG CATACACAGG TTAGAACAAG TAGACTCTGG CAGCAGATCT 004160 004161 CCAGAGACCC AAGTTTAGGT TCTCATAGTG TATTTGAAGT AGTTATACTC CTGGCTTAAG TAGTTTAGTG CCTGGGAGAA 004240 004241 TCCATTACTG AAAAGCATTT AACTTAAAAA AAAAAAAAAA AAAAAAAAAA AAAACTGAAA AGGTAGTGAA TACAGAATAG 004320 004321 CACAATATAT AGGAAAGGAT ATTTCCTGTT GAAAAAAAAA GCCATAAAAT TAATAGTAAT TTTCAAGAGG TAGAATTTTA 004400 004401 GTAGCAATAA GTTTGTGCAT GTATAGTAAT TTGCATTAGC AAGGTTGTAC AATAGAATAA GTGATACTAC TGGAGTTTGT 004480 004481 GGGGCTCTGC AACCAAGAGT TGCACAAGGG CCAGGTGCGG TGGCTTACAC CTATAATCCC AGCACTTTGG GAGGCCAAGG 004560 004561 TGGGCGGATC ACAAGGTCAA GAGATCAGGA CCATCCTGGC CAACATGGTG AAATGCCATC TCTACTAAAA ATACAAAACT 004640 004641 TAGCTGGGCA TGGTGGCACA TGCCTGTAAT CCCAGCTACT CAGGAGGCTG AGGCAGTAGA ATCACTTAAA CCTGAGAGGC 004720 004721 GGAGGTTGCA GTGAGCTGAG ATCACACCAC TGTACTCCAG CCTGGTGACA GTAAGACTCC ACCTCAAACA AACAAAAAAT 004800 004801 GCACAAAAGG AAAAAATGTT CTGGATAAAG AGCATATGAA AGGTACTTTC TTTTAGAACA GTATGAATGT ATATGAATTT 004880 004881 ATCTTTATGT GAGAAATAAT CTTTTTTGTA AGTTAAAGGT TAAAGACCCT GCTTGTTTCC TAAATCAGAG GGTTAGAGCT 004960 004961 GTTGAAATTA AACCTTTATA GTGCTTAACC TGGAAACAAA TGTACTACAG CCCCACTGAA GCCGCTCTAT GGGTTTTTTG 005040 005041 CTTACGATGT TTTAGCAACA GGCATTTATT TTGTAGAATG GTATACTTTC TGCTTTGTCT CCTCATCTTT CTCCACTGGT 005120 005121 TTCCTGGGTA CATTTTTTTT AAAGGGAGAG AAGTTTGTGA GTTTAATGTT TTAAAAAAAC TCCCAAGAAC ATGGATAAGC 005200 005201 CGGATTTCTC TCATGCTTAT GATTAGGGAG TTAGGATTTA AAGATGCAAA GCAGAAGGAC TGAAAGGAAT AGCCAGTGAA 005280 005281 TATGTTTCAG TGGGTGAGGT GTGAAACCTT GTCTAATATA GATGTGTCCT ATGGCCTGTG ACTGCTTATT CTTTATCAAT 005360 005361 GAGAACTCAG CAAACTAGTT TCTTTCTTGA TCTGAGGAAC CACACAGCTC ACATCAGAAT ATAATAGTGG AACTAGGGTG 005440 005441 ACTTCACTCC CTTTCACCTG ATGTCTATCT TGGCCTTTTA GCACCTTGAC TATCCCTGAA AAGACTGGGT CTTTGTTTTC 005520 005521 CCAGGGAAAA AACGAAGTGA TGTAGATCTA AGAAATAGTG CCTCTTTAAT ATTTAATTCT TACATGACAA CTAACACACA 005600 005601 GGGAAAAGGC TATGTTAAGT TGATTATAGC TCCTCTTAAA ATGTCCTATG CTGTCAGTTG GTCTTAGAGA CATGGGAATA 005680 005681 ACCAAGCAAT ATTCAGACAT CTGCACTATC TGGGGACAGC GCTACATAGT ACAATGATGT CAGCAGTTCA GTTACTTGGA 005760 005761 ACAATTAAAG ATTACCCTTA ACAGCCATGT TAATACATCT AAATGCTAAA ATATACTACG AGTTTTTCAT AGTCTTGAAA 005840 005841 GTATACAGTT AATTACTTTT CAAAGTTACT GTGGTCTCAT GTTTACTCTT CTTGTATCTG TGATATGCAA AAAGATGAAG 005920 005921 ACTCTTGGCC TCCAGGAGTT TACATTCTCA TGGTGCTGTT GGTTCAAGCA GATTGCTTTA GTTTATTAAT GAACATTGCT 006000 006001 TGGCTATTAA TTATATCCTA TTTGGAAGGA TCCCTTGGTG AACAGTTTTA AAAAGCAGAG GGCTGTGCTA AATTTCAGGG 006080 006081 TATTGATAGC TTGAGTTTAC ATTGTATTAG CCCTGCTCGT TATCATTTTT TTCCCCAGGG AGCTATGCAG GTAATGCTCA 006160 006161 TTAGCATGAA TCAGAAAAGA AACCATTCTG CCTAAGAGCA TCTTAACCAT CCCCCTAAAC CACCTATGCT CTCCTGTTAT 006240 006241 AGTTGTCAGT AAATCACGAA GAAAATTAAC AGCTCCTTAA GACTCTACAT CCCTCAATTC TCTTTCTTTT CCCAGAGTTT 006320 006321 GTACATCATT CTCTACTCAG ATGGACCAGG ATTTGCATAT AAGCCTTTTA AAACTGACTA GTGGTCCTAA TTTTAACATT 006400 006401 TTTGTGTATG ACTCCTATCC CTTTTCTGAA GCAGCATTGT GATAGATGTG GAGCTTCTAC CTGCATTTCT AAGCAATTAT 006480 006481 TAACCCAACT TTTGAGTTGA AACTTGCATG GATCCTTGTT ATGTCCCGTA ATTCCTCTGA ATCAAGGAAT TTATTTTGCA 006560 006561 TGCTTATTAA ACTCAAACTG GGTCTGATTG AAAGTGCAAG CAATAGTGAC AGGACCTTAA CTCTGGTTTT AGAGTACGAA 006640 006641 CATTCTAATG CATGACTCAA AATGTCCAGT GTTGTGGTTA CTAGTTATTT TATATATGCA TTTGTTAATA ATGAAGCAAT 006720 006721 AGAGACTAAG ACCAATAGCT TGAATATATT CAGATTATTT TCATGTTTTA ATAAAGGATT TTTCTTACTT CCATTGAAAA 006800 006801 TGGGAAGTAG AAGATAAACA GGGGCAACCA CAAGACATTC AAACTGTCAG GACTAGGGCG TAGCAGTGCC CACCCTCTAA 006880 006881 CCACTTGCCT GGTTCCATTA GTCCCCAAGC ATGTTTGAAA ACAAAAGACA CAAACTAAGC ATGCTGAATA AAACTAGCTG 006960 006961 CTATGGCTGT AATAATCAGA AAGGTGCAGA GTTTCAGAAA GAGTAGGAAA GTAGGGAATG CCAGTATGGA GTATGTAAAA 007040 007041 TAACTAGATA TGGATATGGG GTTTGTTTAT GATATGCTTT ATGTAGACAA AGTTTGAGGT CTTTTAAAAC TGGGATTTGA 007120 007121 GTTGAAAAGA GTCAGGATGC ACATATTTCC ACTATTTCAG GATTTTCAGA TGACTAGGCA CATGTTGTGG ATGATACTGG 007200 007201 TACCAACTAC CAATGACCAA CTATAAAGTA CCCCTGCAAT AAGGGAGACT TCCTTTTTGT AGAATAGTCC TGAAAATACT 007280 007281 GACAGATCTG TGGTTAGTTT GTTATTTTAT TGCATAAAAA ACAGTTTAAA CAAATTTTAT AGCCAAAGTT TTATCCTTGA 007360 007361 TGGGTTTGGC CAGACTGCAA TTTCTTGACT AAAGCTTTTA ATGCCAGGTT AAACAGGAGA AACTTTTTCC ACTAGAAGAA 007440 007441 AATCCTTGCT ATCTATTTTT TCCAATAGAA GAAAATCCTT GCTATTTATT TTATTTGATG AATAAACAAA TTTATTGCAG 007520 007521 TAGCTTAAAA AAATTTTTTT TTTAAACAGT CTCACTCTGT CGCCCAGGCT GGAGTGAAGC AATGTGATCT CAGCTCACTG 007600 007601 CAACCTCCAC CTCCCGAGTA GCTGGGATTA CAGACATGCA CCACCACCCT CAGCTAATTT TTGTATTTTT AGTAGAGACG 007680 007681 GGGTTTCGCC ATGTT