NONHSAT084827

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Annotated Information

Name

TUG1: taurine up-regulated gene 1 (Young (2005)).

Characteristics

Multiple Tug1 isoforms, with a main 6.7kb transcript in mouse. Spliced (Young (2005)).

Function

Required for the proper formation of photoreceptors in the developing rodent retina (Young (2005)). Downregulation in developing retina leads to decreased retinal transcription factor expression and increased apoptosis (Young (2005)). TUG1 expression appears to be activated by p53 upon DNA damage, (Guttman (2009)) with many p53 binding sites in the Tug1 promoter (Khalil (2009)). Tug1 associates with PRC2 (polycomb repressive complex 2) and represses a number of cell cycle genes (Khalil (2009)).

Expression

Expressed in the developing retina and brain (Young (2005)). Expressed in adult tissues with highest expression in cortex (Young (2005)). Expression levels are elevated in the caudate nucleus of patients suffering from the trinucleotide repeat neurodegenerative condition, Huntington's disease (Johnson (2012)). Localises to both the nucleus and cytoplasm (Khalil (2009)). Transcript was classified as unstable with a half-life >4 hr in human Hela cells (Tani (2012)). Similar results were found in human B cells and mouse 3T3 cells (Friedel (2009), Clark (2012)).

Conservation

Mammals - identified in mouse, rat, cow, dog and human (Young (2005)). Present in two locations in rat, with one an apparent processed pseudogene.

Misc

Nb: Mouse NRED accession is specific to one of two Tug1 isoforms.

Transcriptomic Nomeclature

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Regulation

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Allelic Information and Variation

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Evolution

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Labs working on this lncRNA

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References

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Basic Information

Transcript ID	NONHSAT084827
Source	NONCODE4.0
Same with	,
Classification	intergenic
Length	7115 nt
Genomic location	chr22+:31365263..31375327
Exon number	3
Exons	31365263..31367765,31368841..31369587,31371156..31375327
Genome context
Sequence	000001 GCGGCCGCGG GATTTGGAGC GGCCGGGGAG GCGGGGGTGG CCGGGGCCGG CTTGGAGGCC TGGCGCCACC CTTCGGGGCC 000080 000081 TGCAAGGACC CAGTTGGGGG GGCAGGAGGG GGCCGGAGGA TGGTTGGTTG TGGGATTTCT ACTTTGCCTT TTCCTCCTTA 000160 000161 TGCCGCCTTA GTGAGGGGCG GGAGCTCTGG CGGCAGCCCC GGGGTGGGGA GACGAGCTCC GGAGTCGGAA GAGCTGGGTT 000240 000241 TTCTTCCGGG CCTAGCCACC AGTTGGCGGA GTGACCTTAG GCGAGTCACT CTGTAATTTG TCTGCGCCTC AGTTTCCTCC 000320 000321 TCTGCCTATC AATGTGTGTG GGGTTGAAAT CGCTTTGTAA ACTATAAAGC GTGGGTGTAC GTAAAGGATG GTTATTGTTT 000400 000401 ATAATTTTTT TTGAGTTGTA AGAAAACTTA GCAGTTCCCC AATCCTTGGG TTTTGAACCT GGGAACCTTG GATTGGAGTT 000480 000481 GGGGATCCCC AAACTTCCTG AAATTGTGGG AATGTGCGGT TTGGGGGAAT GATGGGAATT TGTGGGAATG TGCGTTTTAG 000560 000561 GGGAATGATG ATCCATCGCT AGCAAGTTTT CCAAGGGGGC TGTGACCCAG AAGAGTTAAG AATCACAATT TCTTCATGCT 000640 000641 ACAGAGAGGA AACTGAGGCC TAGATGTCAT TTGGGACCCT TCACAACCAT TTTGAAGCCC TGTTTGAGTC CCTGGGATAT 000720 000721 GTGAGCTGTT TCTATGCATA ATGGATATTC GGGGTTAACA ACAGTCCCCT GCTTGGCTTC TATTCTGAAT CCTTTTCTTT 000800 000801 CACCATGGGG TGCCTGAAGG GTGGCTGATG CATATGGTAC AATGGCACCC AGTGTAAAGC AGCTACAATT AGGAGTGGAT 000880 000881 GTGTTCTGTA GCATCCTATT TAAATAAGCC TATTTTATCC TTTGGCCCGT CAACTCTGTT ATCTGCTGCT TGTACTGGTG 000960 000961 CCTGTACTTT TCTGACTCTC ATTGACCATA TTCCACGACC ATGGTTGTCA TCCATTACTT GATCCTACTT TACATGTCTA 001040 001041 GTCTGTGTGG TTGGTGGTGA ATAGGCTTCT TTTTACATGG TGCTGCCAGC CCAGCTAATT AATGGTGCAC GTGGACTTTT 001120 001121 AGCAAGCGGG CTCACTGGAA GAGACTGAAC CTGGCATGGA ATTCCTGAAG ATGTTTGGGG TTTTTTTCTT TCTTAATCGA 001200 001201 AAGTTAACAT TGTCTGAAAA GTTTTGTTAG AACTACTGCG GAACCTCAAA ATCAGTAGAT TTGGAAGTGA TTCAAAGCTA 001280 001281 AACTTTTTCC TTGGCCCTCC TTGTGTTCTA ATTGCTTGCA AGTGTAATAC TAGGATGTCC AAGATGCCAG TTTTTGCTTC 001360 001361 TTTGTTAGTT GTCAGCTGCT TTTATCAAAT TTCAGGCCAT TATCCAACAA ACACTATAAA AATGTTTGAA CAATTGGATT 001440 001441 TCAAACATTT TCGTTTTGTG GAGTGGTGCT CACCAAGTGG TACAGCCCTA AGCAAGTGAA CACAAACACA TTTAAGTGTA 001520 001521 TTTTGTCTGA TTAGATGTTA GCCAGTTATG CTATTTCATT CAAATGTCTG AAAAAATCAA TTGACTATTC CCTTTTCCTA 001600 001601 AAGGGCAGAG ACAGATAATC TCACTTCCAG AGAAATGACT TGGAGAAAAA AAAGTGTTGG TCTTTTTGCT CTTTTGTAAT 001680 001681 TAAATCCGGA TGTACCTCAA AAGACTTAAG ACTGTGGTGA TAAGATGCTT TCCTCAGCAG AAAGGAGGGA AAAAAAACAA 001760 001761 CTGGAACTCA AAGCTTGAAA TTCTGTGGCA AAACATGAGA TGTCCAGGAT TGGAGGTTGA AAAGATTTCA CTACAGTGTT 001840 001841 CTGCAATAGT TGGAGCAGAT AACTTTCAGT GTAGCCACAG CCATGGACTC CAGATTTCCA GATTTTCAAG ACCTGGACCT 001920 001921 GGAACCCGAA AGAGCTTGTC ACGATGCGGC AGGAACACTG GAGGTAGATT TTTTTTTATT TTTGAATTTT GGGACTGTTG 002000 002001 ACCTTGCTGT GAGAAAAGAG ACAACGACTG AGCAAGCACT ACCACCAGCA CTGTTACTGG GAATTAGAAG ACCTGAGTTT 002080 002081 CTGTCCAGAC CCTCAGTGCA AACTGAGGAT GCTCCATCCA AAGTGAATTA TGTCCTGTGC CTCCTGATTG CTGAGTGTTC 002160 002161 ACCTGGACCT TCTGACTACC TTCCCTGTGC TATTCCATCA GCCTACAGAC CTGGTACCTG GATTTTTGCC CGAGATGATT 002240 002241 CCTACCACCT TACTACTGAC GAAGACACCC ATTCCAGTGG ACCACTGTGA CCCAGGAGGC ATTCAGCCAT CATGATGTGG 002320 002321 CCTTTACCTC CACTCCTGTC TTGTTCTACC CAGATTCAGC ACAGCCCTTT ATAGTGAAGT CAGAGTCCTC AAGCCAAATA 002400 002401 GCTAAAGCTG TTTTATCACA ACAAAGGCCT AGTTTGTTCC ATGAGTGTGC ATTTCATTTC TTCAGTTAAA GCCTTCAGAG 002480 002481 ACACACAATA AATTTGGACC AGGGGATTTT TTAGTTATTA ATGCTCTCTG AAGAAAGGCA ACATCTTTTT GAGAGCAGCA 002560 002561 TTGGACCACA CCCCACAATC TCAAATGATT GAAATTCATG AACATCTAGG ATCCCGTGAA GGTCACTGGA CCCTGTTTTT 002640 002641 TCTACTTCAA ATCCTGTAGT AGCCTACTGA ATGAGAAAAC ATATTCTGAC CCATTGGGAT CAAATCAAAG GCACAGTGAA 002720 002721 CTCCTCATAG CATCTTCTTT GGAATTACTC AGGAACCAGA ACTTTTTACA CAAATGTAAG AAATTCTACC AAGGAGTCCC 002800 002801 CTTACCTAAC AGCATCTCAC AAGGCTGCAC CAGATTCCAG AAAAGGCTTC TCTTGATACA TCAAGGTAGA ACCTCTATGC 002880 002881 ATTTTGTGAC CGACTTATTC TTAGATCATT GGTTTTCCAA AGGCTTTGTG GCCATGAAGC CCTTTGAGTG AAAACTGTGC 002960 002961 AGAAGCCCAG AGTAAAAGTG AAGCTGCTCT GGATGAAGTA GTGAAGCAAG AGTAGGGGCC TGAATCCTGC TACAACTATC 003040 003041 TTCCTTTACC ACCGTGGTGA CACCTAAGGG GACTTCCTTA CAACACCTTG AACTCTTCCG AACACAGTTT GAAAACCACT 003120 003121 GCCCCAGACA GCAATATGTT TGACCTGAAT GGCATTCCAA TCTTTTCTGT ACCTCCACTC AGCACAGTTC ATGTTCAGTA 003200 003201 GATGCTGAAC ATTCTTAGAA ATACTGTGTG TGAACTTAGA AAAGTGCAAG AAGACAGGCA TGTCTTTGAC CCCAGGAATG 003280 003281 ATCATTTGCT GAAGATGGTG TCAAGTGAAC CTAGATTAAC AGCCCTCCAC TCCAGATGGA TATCCAGTGA TTCCTAGAAT 003360 003361 GGGATATAGC CAGAGAACAA TTCTATGCAC CCTACACTGA CAGACTCCCT TAAGCAACAC CAGATGCTCT ACTGGTACTT 003440 003441 GAAGTACATG ACTTTGAAGT CTTGACCCTC CATGAATACC TGAATTATCA GCAAGCGGGT TTTGAAGCTG GTGCCTCATT 003520 003521 GAGGCCATAT TAGAGCAACT TGTACATTTG ACCTCTTGTT ATCAGCCATG GTACTCTACT TCGTGTGCAA GAGATAACTA 003600 003601 TGAAAGCCAA ATTCAAATAC TGGCAACATT TCCTAAAGGG GCTCAATATC TATCATTCGT CTTCTTTTCC AAACTACACA 003680 003681 TCACTGTATG ACTCAACCAG TAGCAGTTAT ATTGCCCCTT GGTTTTTATT CAGTTTAACT ACTGTTTCCA AGATAAATGA 003760 003761 GCTAATAAGC TTTAAAAAAA AAAAAAAAAA AGGCTGAATT CTTTTTTCTT CATCACTGGC ATATCTGCCT ATTCTCCAGA 003840 003841 ATTATTATGA CTATTCAGCT CACTTTAACA GTTGAACTTC AAGCGACAAT CTTTGAACAC CCCTTCTCAT GTGATTTAAA 003920 003921 ATGAAACCAT TTGGAAAAGT TTCTTCTAGC CAGTAATAGA TTTTTTTTTT AATTGCTCTG CCTTGTGCCG AGAGATGTTC 004000 004001 TTTTAAGATG AATCTTTTGA TGTCTGATAC CACCAAATAT AGGTGGTAGG GAGAGTTGGA GGCTGGCCCT TTGAGCAGGC 004080 004081 CATTAGCTTA CTTGCTGGGC ATTTCCGATA GCTTATTGCC TACCTTTTTG CTGGAAACAA ACTGATTTGA AAAACAAAAT 004160 004161 CTATGAAGAC TGCAGCTAAG GATTTTATCG GTAGACTTAA GAGCTTTTGT CCTTGTGGAT ATTTTAGTGG AACCACATCA 004240 004241 GTCTCAATAC TGTCATTTTA CACTGACTCA GAGCAGCTGA CTTCATTCCT TGCCATGATA TATATTTAAG GCAGGCATTG 004320 004321 TAACAGACAT AAAGACAACT TATCTGTTTC AGCAGGAAGG ATTCAGTTTA TGAACTCTCA GACCAGATCA TGTTGAACAA 004400 004401 GGAGACTTTG ATGTGTGTCA TGAGAAAACT CATTCTTTAC TTCCCAGTCA ATTTAAAGGC CAGCTATCCT GAGCTACTCG 004480 004481 AATGAATGCA CTGGTTAAAC ATTGGAAATA GTTTGTTTAT ATCCTTGTCT CTCTCTAGGC CAATTGTGAT TACATGACTC 004560 004561 GACTCTACAT CTCGTCAAAC AAGGCCTAGG TCTGGTTGCT GTAGACTGCT CGCCCTCAAC AAATAAAATC TGGTTGACTA 004640 004641 GCCTCCTTGT ATATACAACT ATTATTTGTT AAGAAGAAAT TATCGTCAAT TTTCTACTAC CTTCCAATTG TCAGCTCTTT 004720 004721 TTTTCCTCTC TGGTTTTTCC TATACTTTAC AGAAAAAGAC ATTGATCTAT ACTGCCATTC CCTCTAATCC TGCCATACTC 004800 004801 AGTCAAAAGG AATGACTTAA GATGAAGATG ATCATCTGCT CGAGTCTAAA ATATACATTG TATATAAGAA TTGGTGATTA 004880 004881 GAAAAGCAAA AAACCTAAAA CTTAAATCTA GGAGTCTGTA TACTGTCTCC ATGTCTCCAT GCCTCAGATC TCATCTAAAT 004960 004961 CTTTGAACAG CACCATTCAA CCAATCTGAG GCCTTGACTT GCTTGTAAGA TGATTCTCAG AGATCGGCTG AGTTAAAAAA 005040 005041 GATGACGACT TGATTACCAA AGAAAGTAGG GCCAACTTTG ACAAATCTGG CTCTGCTGAC CCTGTCACTC CCAGATGTAG 005120 005121 CATAGACTCC TAAACAGAAC CTCAAGTCTG ATTGAGGATA AGGCCTTCTC CTGAGCTGAA AGTTCTTTGG CAGATGAGCA 005200 005201 AGAAACTGAA AGCTGATGTA CCTGACTGGC TCTGTAAGAT CAGAAAACTG TATCCAGAAT AAGCCCTATG GATTAACCCC 005280 005281 TGAGTACCCA GAGTAAAAAC TAATTTACAG AACTTCCTTA TTGATCTGCT GGTTCTTCCA GATCATATTC TGGCTATTGG 005360 005361 TATGGCTGGC CTTTCTGAAG GTACCCTGCT TGTCTATTTT CCTGACTCAG CTCTTGCCTG CCTTTTTCAC ATGTTGCTGC 005440 005441 AATTAGACTC ACCGTGAGGA CTACAGTCAA TTTCAGTCTA TCTTGTGCCC AATACAACAA GGATTTTTAA TAGTAACAAC 005520 005521 CCACACCTCA CCCACTAGGA CTCAATGTTC ACAACAGGAA GGACCATTGC TGCATACTCC TTGACCAGCA ACTTTTTTGA 005600 005601 AGATATTTTT AAGTGCAGAG TAGGCCTCTA TTCCTGTATG TAATTGTTCA TTTTCAGCAC CTGGAACCTC ATCTATCGGG 005680 005681 TCTGGAAGGA ATACAGCAGT TC