BCL6-AS1

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BCL6 translocations occur at distinct sequence motifs within intron 1 of the BCL6 gene that are recognized and deaminated by activation-induced cytidine deaminase (AID).

Annotated Information

Name

Approved symbol:BCL6-AS1

Approved name:BCL6 antisense RNA 1

HGNC ID:HGNC:51843

Previous name:BCL6 antisense 1

Alias symbol:lnc-RP11-211G3.3.1-1

Expression

Expression of BCL6-AS1 was detected in the germinal cell B-cell type of DLBCL and at a lower level in the activated B-cell type of diffuse large B-cell lymphoma (DLBCL)[1]

Diseases

diffuse large B-cell lymphoma[1]

Labs working on this lncRNA

  • University of Southern California Norris Comprehensive Cancer Center, Departments of Pathology, Biochemistry & Molecular Biology, Molecular Microbiology & Immunology, and Biological Sciences (Section of Molecular and Computational Biology), University of Southern California Keck School of Medicine, Los Angeles, CA.

References

  1. Jump up to: 1.0 1.1 Lu Z, Pannunzio NR, Greisman HA, Casero D, Parekh C, Lieber MR. Convergent BCL6 and lncRNA promoters demarcate the major breakpoint region for BCL6 translocations. Blood. 2015 Oct 1;126(14):1730-1. doi:10.1182/blood-2015-07-657999. Epub 2015 Aug 14.