CHASERR

CHASERR, a highly conserved long noncoding RNA transcribed from a region near the transcription start site of Chd2 and on the same strand, acts in concert with the CHD2 protein to maintain proper Chd2 expression levels.

Annotated Information

Approved symbol：CHASERR

Approved name：CHD2 adjacent suppressive regulatory RNA

HGNC ID：48626

Previous name：long intergenic non-protein coding RNA 1578

prev_symbol：LINC01578

RefSeq ID：NR_037601

Characteristics

CHASERR, a highly conserved long noncoding RNA transcribed from a region near the transcription start site of Chd2 and on the same strand.<ref name="ref1">.

Function

Loss of CHASERR in mice leads to early postnatal lethality in homozygous mice, and severe growth retardation in heterozygotes. Mechanistically, loss of CHASERR leads to substantially increased Chd2 mRNA and protein levels, which in turn lead to transcriptional interference by inhibiting promoters found downstream of highly expressed genes. <ref name="ref1">.

Regulation

Loss of CHASERR leads to substantially increased Chd2 mRNA and protein levels, which in turn lead to transcriptional interference by inhibiting promoters found downstream of highly expressed genes <ref name="ref1">.

Expression

CHASERR production represses Chd2 expression solely in cis, and that the phenotypic consequences of CHASERR loss are rescued when Chd2 is perturbed as well<ref name="ref1">.

Disease

• neurological disease<ref name="ref1">.

Labs working on this lncRNA

• Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel<ref name="ref1">.

• National Institute for Biotechnology in the Negev and Department of Microbiology, Immunology and Genetics, Ben-Gurion University of the Negev, Beer-Sheva, Israel<ref name="ref1">.

• Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel<ref name="ref1">.

• Department of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel<ref name="ref1">.

• Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel. igor.ulitsky@weizmann.ac.il.Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China<ref name="ref1">.