DACOR1
Contents
Annotated Information
Approved Symbol
DACOR1
Approved Name
DNMT1-associated colon cancer repressed lncRNA 1
Previous Symbols
Synonyms
TCONS_00023265
Chromosome
15q22.33
OMIM ID
_
Ensembl ID
_
pubmed IDs
26307088
Disease
- colon cancer[1]
Function
DACOR1 induction resulted in down-regulation of Cystathionine β-synthase, which is known to lead to increased levels of S-adenosyl methionine-the key methyl donor for DNA methylation. [1]
The deregulation of DNMT1-associated lncRNAs contributes to aberrant DNA methylation and gene expression during colon tumorigenesis.
Expression
DACOR1 (DNMT1-associated Colon Cancer Repressed lncRNA 1), shows high, tissue-specific expression in the normal colon (including colon crypts) but was repressed in a panel of colon tumors and patient-derived colon cancer cell lines. [1]
Labs working on this lncRNA
- Department of Genetics and Genome Sciences, Department of Biochemistry.[1]
