DINOL
p53 is a DINO-binding protein[1]
Germline disruption of mouse Dino impairs the p53-dependent, DNA damage-induced apoptosis[1]
Contents
Annotated Information
Approved Symbol
DINOL (damage induced long noncoding RNA)
Synonyms
DINO
Chromosome
6p21.2
RefSeq(supplied by NCBI)
NG_009364
Characteristic
DINO is a 951-base RNA transcribed divergently from CDKN1A.[1] DINO occupancies at p53 binding elements in 7 of 10 p53-target genes examined, including CDKN1A, GADD45A, and DDB2.[1]
Function
DINO encodes a p53-dependent DNA damage-induced transcript.[1] DINO stabilizes p53 and enhances regulation of its target genes.[1] Loss of DINO abrogates DNA damage-induced gene regulation and cell cycle arrest.[1]
Labs working on this lncRNA
- Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, California, USA.
- Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California, USA.
