FOXC2-AS1

Annotated Information

Name

Approved Symbol: FOXC2-AS1

Approved Name: FOXC2 antisense RNA 1

Synonyms: ODRUL

RefSeq ID: NR_125795

Ensembl ID: ENSG00000260944

LncBook transcript ID: HSALNT0288979

Chromosome

16q24.1

Characteristics

-

Function

FOXC2-AS1 was significantly upregulated in breast cancer (BC) tissues and cell lines..

Silenced FOXC2-AS1 caused cell cycle arrest and induced apoptosis.

• Loss of function revealed that silenced FOXC2-AS1 significantly suppressed the proliferation ability, and flow cytometric analysis illustrated the influence of FOXC2-AS1 on cell cycle and apoptosis rate. Cyclin D1, cyclin D2, and cyclin D3 were all partly positively modulated by FOXC2-AS1 in breast cancer (BC)..

Regulation

-

Diseases

Breast cancer

Expression

FOXC2-AS1 was significantly increased in BC tissues and cell lines, and Kaplan–Meier survival analysis indicated that a high level of FOXC2-AS1 was associated with poor prognosis of BC patients.

Experiment	Forward primer	Reverse primer
Quantitative real-time PCR	5'-TTCATCGGCTGCGTATTCG- 3'	5'-TTGCCTTCTAGTCGCCTCC- 3'

Evolution

-

pubmed IDs

26408180, 29562954

Sequence

>gi|672890592|ref|NR_125795.1| Homo sapiens FOXC2 antisense RNA 1 (FOXC2-AS1), long non-coding RNA

000001 CTTGCCGGGC TTCTTGTCGT CGCGGGGCAC CTTGACGAAG CACTCGTTGA GCGAGAGGTT GTGGCGGATG CTGTTCTGCC 000080
000081 AGCCCTGCTT GTTCTCCCGG TAGAAGGGGA AGCGGTCCAT GATGAACTGG TAGATGCCGT TCAAGGTTTC CTTGCACCCT 000160
000161 TCCTGGCTGT TCATCGGCTG CGTATTCGAT TCTCAGCAAA AGGATGTTGA GACAACCCAC CAGGCCTCTT CGCTTCGGCC 000240
000241 TCTTCGCTTC GGGGAGGCGA CTAGAAGGCA ATGGGGCGTG CCACTTATTT CCAATAAAAG AACAGAAGAC GAAAATGTA

Labs working on this lncRNA

• Department of Breast Surgery, the Affiliated Hospital of Guizhou Medical University, Guizhou, P.R. China