GCSIR
GCSIR expression and HCV replication has a positive correlation.
Contents
Annotated Information
Name
Approved symbol:GCSIR
Approved name:GPR55 cis regulatory suppressor of immune response RNA
HGNC ID:HGNC:54400
Alias symbol:Lnc-ITM2C-1
RefSeq ID:NR_038238
Characteristics
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Function
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Regulation
HCV induces GCSIR expression, while GCSIR indirectly favors HCV replication by stimulating expression of its neighboring gene GPR55, which in turn downregulates expression of ISGs.[1]
Expression
GCSIR is upregulated early after HCV infection.[1]
Diseases
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Labs working on this lncRNA
- Institute of Biochemistry, Medical Faculty, Justus-Liebig-University, Friedrichstrasse 24, 35392 Giessen, Germany. cannyhp@126.com.[1]
- Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), 35392 Giessen, Germany. jochen.wilhelm@patho.med.uni-giessen.de.[1]
- Institute of Biochemistry, Medical Faculty, Justus-Liebig-University, Friedrichstrasse 24, 35392 Giessen, Germany. gesche.gerresheim@gmx.de.[1]
- Institute of Biochemistry, Medical Faculty, Justus-Liebig-University, Friedrichstrasse 24, 35392 Giessen, Germany. ludmilashalamova@gmail.com.[1]
- Institute of Biochemistry, Medical Faculty, Justus-Liebig-University, Friedrichstrasse 24, 35392 Giessen, Germany. michael.niepmann@biochemie.med.uni-giessen.de.[1]
