LINC00319

Annotation

Name

Approved symbol: LINC00319

Approved name: long intergenic non-protein coding RNA 319

HGNC ID: HGNC:19730

Previous symbols: C21orf125; NCRNA00319

Previous names: chromosome 21 open reading frame 125; non-protein coding RNA 319

Alias symbols: PRED49; FLJ38036

RefSeq ID: NR_026960

LncBook ID: HSALNT0289323

Characteristics

Relative LINC00319 expression in lung adenocarcinoma tissues and its clinical significance

Long intergenic non-protein coding RNA 319 (LINC00319) (NR_152722), is located on chromosome 21q22.3 and has a transcript length of 2901 nucleotides^[1].

Expression

LINC00319 was significantly up-regulated in lung adenocarcinoma tissues compared with normal lung tissues^[1].

Reported to be highly expressed in lung cancer^[2].

Regulation

Please input regulartion information here.

Function

LINC00319 is a direct target of miR-450b-5p

Linc00319 promotes cell proliferation and invasion in lung cancer cells by directly binding with and downregulating the tumor suppressor miR-32.^[2]

LINC00319 was also shown to regulate the miR-450b-5p targeted gene enhancer of zeste homolog 2 (EZH2) by functioning as a competitive endogenous RNA (ceRNA) for miR-450b-5p in lung adenocarcinoma, thereby inhibiting the expression of EZH2 and promoting lung adenocarcinoma cell proliferation.^[1].

Disease

lung cancer ^[2]

lung adenocarcinoma carcinogenesis ^[1]

Evolution

Please input evolution information here.

Labs working on this lncRNA

College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, China.^[2]
Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang 441021, China.^[1]

References

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Zhang ZW, Chen JJ, Xia SH, et al. Long intergenic non-protein coding RNA 319 aggravates lung adenocarcinoma carcinogenesis by modulating miR-450b-5p/EZH2[J]. Gene, 2018, 650: 60-67.
↑ ^2.0 ^2.1 ^2.2 ^2.3 Zhou B, Yuan W and Li X. Long Intergenic Noncoding RNA 319 (linc00319) Promotes Cell Proliferation and Invasion in Lung Cancer Cells by Directly Downregulating the Tumor Suppressor MiR-32[J]. Oncol Res, 2017.

Sequence

>NR_152722.1 Homo sapiens long intergenic non-protein coding RNA 319 (LINC00319), long non-coding RNA

000001  GTTTAGATTA GGTTGGAAGT CACCTGGGCT GAGCTGATGG CTGATTCCGT CAGCAAAAAG AACTGTGGAA CATACTGGCA  000080
000081  CTTGGGCCGG TGTGAAGCCA CCCCCCTGCC ATGAAAAATG GCTCTTCCCT GCCACAGCCG GCCCAGCGGG AGCCAGGTCA  000160
000161  GGGCCTGGAG ACACAGCGCC CCCCACCGGA GCCACTGCCC GGCCCAGCAG CACCTGCGGA GAATCCCACC AGCTCCCACG  000240
000241  CCTCCCGCCG CGCCACCGCC CCGGCTTTCT GCAAATCCAC CTTATGGAAG CCGGATAAGC ACCTCCTCCT CTGATGCGTC  000320
000321  ACAGTCACAG GTCCTGGTGA GGAGGGAGCC ACGCCAAGCA CAGCGGCTGG AACAGGGGCA AGTGGGTGCC CACCCCGAAG  000400
000401  TGCAGGCAAT GAACTTGTGC TGTAGCCCAT GGTGAGCTGT GGGGCTGTTT GTGACTGCAG CGTAGCCAAG CCCATCCCGC  000480
000481  CTGATGCGGC CTCTTCATCC AGAGTGGGGG TGACGTGCCA GCCCCCACCT CACCGGAATG CTGGGAGGAG CGTCTCCACG  000560
000561  GAAGGAGCTC ACTTTGTCAG CTGTAATGTG CTGTGACTAT CGTAAAGTTC CTTCCGGGTG CAGAGTGATA CATGAACCCT  000640
000641  GGGGACTCAC TCCAACTTGG TATTGATTTT CTCCACGGAG GACCCAGCAG TCACGGCCCG TGTCTGCACA GCCCCTTGGA  000720
000721  TCCTGCGGAG GAATTCAGCC GGCCCCTCCC CCTGTGCCGA AAACCACGGA GGCAAAGCCA GGCCAGGGTA CAGTGAGAAC  000800
000801  ACGGGAGAGG ACTGAGAGAC CGCTGGCTGC CGAGGGAGGA AGAGCAGGAT TCGCACCCCC GTCATCGCTG GGCCCACACG  000880
000881  CCGCCGACAG CTTCCGCGTG TGGCCATCTG TCTTTCAGAA ACCCTCTGGC AGAGGGACCC AGCAGATGAC ACGGGGGCCG  000960
000961  TTCACACTCT GAAACCTGCC TGGAGTCAAA ACACTGCTGG CGAGCCTCCA CCGCAAACCC AATCCAGATG GTCTTCCCTG  001040
001041  GTGGCCCTCG GGGTGGCGGG CACCCTGCCC ACTCCCTGCC AGCCCCTGCC CGCTGGACTC CAGGCCCGGC CGAGCCCCCG  001120
001121  ACCGGTCTCC TGACCCAGCA TGCTGCTCTC CCCTGGGCCC GGCTTTCTCG CCCGCTGGGA CTCCCAGGCC CCTCCAGCCC  001200
001201  AGCCCCGAGA GCAGGAGCCC CAAGGGAGGC TTGGCGGCTG TGGAGGCGAG TGGGCCACGT GTAGCTGGGA GGCCGGCAGG  001280
001281  ACCAGGAGCC CCTCACAGCG CAGCACCCAC AGCATCACGA GCCACTTCCA CTCCTGGGTG GCCTGGGGGC CCCCACCCTG  001360
001361  CTCTGAGCTG CCCCTTGTTG TGACCTGGGG TCCCCCGTGG TGGGCCCGCC CCTTGAGCCT GGGATCCAGC CTCAGCGAGG  001440
001441  CTCCAGAAGT GTCGTCTCCG CCGGCCAGGC GTCAGCGCCT CCACCCAGGA TCACACACTC CTATCTCTGC ACTTCTGCCC  001520
001521  TCCATCCTGC TCCACGCCGC CTCTGCTTGT TATTCCAGCA CATTCCAGGG TGATGCCTGC TGAAGCCACG CAGCCAGTGC  001600
001601  CTCCACCCTA CCCCCCATCT GACCCACCGG CCCCTTCCGC ACGCTGGAAG CCTGCCCGGC CTGAAGTGTC CTCACCTGTC  001680
001681  GCCCTATCCT CCCCTCCACT CCAGCCCACC GGTGACTCAG CCCTCACAGC TCTCTCCTCC CCGAGGGAGC CGGTGACTTG  001760
001761  GCTCTGATGG TGCCGGGACC CAGCCCCGGC ATGTTCAGAA TCCTTGTCCT TTAACCTGCG TCCACATGTA GTCGCCTCCA  001840
001841  CCTCCCTGCC TGAACCTCCA GGCCCTGCAG AGCAAACACT GCTGCCTGCA GGAGACCCCT GGGGCCTTCT CCGTCCCCTC  001920
001921  ATCCTCCTAA GGAGCCTCCC CTGCCACCGT GCCAGAATGT GCCGGAGGAA CAGAGGCCCG AGCCTCCCGT GGCCCCAGCG  002000
002001  AGGCTTCCTC TGGGGAAGAC AGTGAGCCCA ACGCCCTGGC TCTCGAGGGG TGGACGGAGT CCAGCTGGCA TCGACCGGGT  002080
002081  GCCCCTCTTC ACCGGTGTCC ACAGTCCTTG AGAGCAAAGG GTTCCCA

[ref2-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Zhang ZW, Chen JJ, Xia SH, et al. Long intergenic non-protein coding RNA 319 aggravates lung adenocarcinoma carcinogenesis by modulating miR-450b-5p/EZH2[J]. Gene, 2018, 650: 60-67.

[ref1-2] 2.0 ^2.1 ^2.2 ^2.3 Zhou B, Yuan W and Li X. Long Intergenic Noncoding RNA 319 (linc00319) Promotes Cell Proliferation and Invasion in Lung Cancer Cells by Directly Downregulating the Tumor Suppressor MiR-32[J]. Oncol Res, 2017.

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