LINC00908
LINC00908 could competitively bind to miR-483-5p to increase the expression of TSPYL5, thereby inhibiting the progression of PCa.[1].
Contents
Annotated Information
Name
Approved symbol：LINC00908
Approved name：long intergenic non-protein coding RNA 908
HGNC ID：；HGNC:27599
Alias symbol：ASRPS
RefSeq ID：NR_015417
Characteristics
LINC00908 encoding a 60-aa polypeptide and differentially expressed in TNBC tissues. [2]
Function
LINC00908 inhibited tumor growth of PCa[1]. LINC00908-encoded polypeptide ASRPS represented a TNBC-specific target for treatment.[2].
Regulation
LINC00908 competitively bound to miR-483-5p to up-regulate the TSPYL5 expression.[1]
Expression
Overexpression of LINC00908 resulted in reduced PCa cell proliferation, migration and invasion, and promoted apoptosis. [1]
Diseases
prostate cancer (PCa)[1] Triple-negative breast cancer (TNBC) [2]
Labs working on this lncRNA
- Department of Urology, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Street, Changchun, 130033 Jilin People's Republic of China.[1]
- Department of Genetics, Medical College of Soochow University, Suzhou, China.[2]
- Department of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, China.[2]
- Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China.[2]
- The State Key Lab of Respiratory Disease, The First Affiliated Hospital, The School of Public Health, Guangzhou Medical University, Guangzhou, China.[2]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Fan L, Li H, Zhang Y. LINC00908 negatively regulates microRNA-483-5p to increase TSPYL5 expression and inhibit the development of prostate cancer. Cancer Cell Int. 2020 Jan 9;20:10. doi: 10.1186/s12935-019-1073-x. PMID: 31938018; PMCID: PMC6953146.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Wang Y, Wu S, Zhu X, Zhang L, Deng J, Li F, Guo B, Zhang S, Wu R, Zhang Z, Wang K, Lu J, Zhou Y. LncRNA-encoded polypeptide ASRPS inhibits triple-negative breast cancer angiogenesis. J Exp Med. 2020 Mar 2;217(3):jem.20190950. doi: 10.1084/jem.20190950. PMID: 31816634; PMCID: PMC7062514.
