LINC00998

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Annotated Information

Name

LINC00998:long intergenic non-protein coding RNA 998

Function

The SNP site, rs12526133, is strongly associated with MDD (Major depressive disorder)(χ2 = 11.68, P = 6.3E − 04), and it is located in LINC01108. Therefore, LINC01108 is most likely associated with MDD [1].

Expression

The expression of LINC00998 is significantly lower in MDD patients than controls based on microarray analysis (FC=0.11,P<0.001) [1].

Disease

Major depressive disorder [1]

Labs working on this lncRNA

  • State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences & Neuroscience Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Tsinghua University, China.

References

  1. 1.0 1.1 1.2 Ye N, Rao S, Du T, Hu H, Liu Z, Shen Y, Xu Q. Intergenic variants may predispose to major depression disorder through regulation of long non-coding RNA expression. Gene. 2017 Feb 15;601:21-26.