LINC01121
LINC01121, Inhibits Cell Apoptosis While Facilitating Proliferation, Migration, and Invasion Though Negative Regulation of the Camp/PKA Signaling Pathway via GLP1R
Contents
Annotated Information
Approved Name
Approved symbol：LINC01121
Approved name：long intergenic non-protein coding RNA 1121
HGNC ID ：HGNC:49266
Alias symbol：UNQ6975
RefSeq ID：NR_033831
Characteristics
LINC01121 is determined to be located on chromosome 2p21, with indications that solute carrier family 3, member 1 (SLC3A1) share the same genetic locus with LINC01121 [1].
Function
LINC01121 influences the growth and apoptosis of pancreatic cancer cells by targeting GLP1R via the cAMP/PKA signaling pathway, in a bid to unearth an effective therapy for pancreatic cancer[1]. LINC01121 induces cell cycle arrest and inhibits apoptosis in pancreatic cancer cells and PANC-1 cells [1].
Regulation
NA
Diseases
- Pancreatic cancer [1].
Expression
LINC01121 is highly expressed in pancreatic cancer [1].
Labs working on this lncRNA
- Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
- Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, Key Laboratory of Organ Transplantation, Zhejiang Province, Hangzhou, China
- Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China
