LINC02303
LINC02303 is an important downstream effector of the tumor suppressor p53 activity.[1]
Contents
Annotated Information
Name
Approved symbol:LINC02303
Approved name:long intergenic non-protein coding RNA 2303
HGNC ID:HGNC:53222
Alias symbol:TRMP
RefSeq ID NR_146546
Characteristics
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Function
LINC02303 suppresses internal ribosomal entry site (IRES)-dependent translation of p27 by competing p27 mRNA for polypyrimidine tract-binding protein 1 (PTBP1) binding.[1].
Regulation
LINC02303 is able to regulate cell proliferation, G1/S cell cycle progression, and tumor xenograft growth via the inhibition of p27. [1]
Expression
Knockdown of LINC02303 inhibits cell proliferation by inducing a G1 cell cycle arrest. [1]
Diseases
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Labs working on this lncRNA
- Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China.[1]
- Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China. meiyide@ustc.edu.cn.[1]
