LINC02605
LINC02605,the long noncoding RNA in human and mouse, play a promoting role in the transcriptional regulation of inflammatory genes in the innate immune system.[1]
Contents
Annotated Information
Name
Approved symbol:LINC02605
HGNC ID:53974
Approved name:long intergenic non-protein coding RNA 2605
Alias symbol:RP11-79H23.3|IL-7|AS
RefSeq ID:NR_157588
Characteristics
location:8q21.13
Function
LINC02605 promotes the expression of several inflammatory genes, including CCL2, CCL5, CCL7, and IL-6, in cells in response to LPS.[1]
Regulation
LINC02605 and p300 complex modulate the assembly of SWI/SNF complex to the promoters. LINC02605 regulates chemotaxis activity of monocytes to intestine epithelial cells with involvement of CCL2. [1]
Expression
The expression of LINC02605 is dependent on the NF-κB and MAPK signaling pathways in macrophages and intestinal epithelial cells.[1]
Labs working on this lncRNA
- Hubei Province Key Laboratory of Allergy and Immunology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, Hubei, People's Republic of China.[1]
- Department of Biochemistry and Molecular Biology, Medical College, Hubei Minzu University, Enshi 445000, Hubei, People's Republic of China.[1]
- Department of Endocrinology, Institute of Geriatric Medicine, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430077, Hubei, People's Republic of China.[1]
- Department of Gastrointestinal Surgery Section, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, People's Republic of China; and.[1]
- School of Computer Sciences, Wuhan University, Wuhan 430072, Hubei, People's Republic of China.[1]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Liu X, Lu Y, Zhu J, Liu M, Xie M, Ye M, Li M, Wang S, Ming Z, Tong Q, Liu F, Zhou R. A Long Noncoding RNA, Antisense IL-7, Promotes Inflammatory Gene Transcription through Facilitating Histone Acetylation and Switch/Sucrose Nonfermentable Chromatin Remodeling. J Immunol. 2019 Sep 15;203(6):1548-1559. doi: 10.4049/jimmunol.1900256. Epub 2019 Aug 5. PMID: 31383742.
