MAP3K20-AS1
Contents
Annotated Information
Name
Approved symbol: MAP3K20-AS1
Approved name: MAP3K20 antisense RNA 1
HGNC ID: HGNC:27935
Previous names: MLK7 antisense RNA 1 (non-protein coding); MLK7 antisense RNA 1
Previous symbols: MLK7-AS1
RefSeq ID: NR_033882
LncBook ID: HSALNT0289162
Chromosome
2q31.1
Characteristics
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Expression
lncRNA MLK7-AS1 was significantly increased in gastric cancer tissues compared with in adjacent tissues[1].
Regulation
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Function
MLK7-AS1 interacted with Dnmt1 and recruited it to miR-375 promotor, hyper-methylating miR-375 promotor and repressing miR-375 expression to inhibit gastric cancer growth, indicating that MLK7-AS1 may be a useful prognostic marker and therapeutic target for gastric cancer patients.[1].
Disease
Gastric cancer [1]
Evolution
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Labs working on this lncRNA
- Department of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Changsha, Hunan, China.
- Department of Ultrasound, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
