MELTF-AS1

From LncRNAWiki
Jump to: navigation, search

Annotated Information

lncRNA MELTF-AS1 is upregulated in human osteosarcoma tissues and osteosarcoma cell lines [1].
Knockdown of MELTF-AS1 suppresses osteosarcoma cell proliferation [1].
Correlation between MELTF-AS1 expression level and FOXP4 protein expression in osteosarcoma [1].

Approved Symbol

MELTF-AS1 (MELTF antisense RNA 1)

Previous Symbols

MFI2-AS1

Chromosome

3q29

RefSeq(supplied by NCBI)

NR_038285

Disease

osteosarcoma

Expression

Compared with corresponding adjacent, histological normal tissues, MELTF-AS1 was significantly upregulated in human osteosarcoma tissues (P<0.0001).[1] FOXP4 protein is upregulated in osteosarcoma tissues and positively correlated with MELTF-AS1 expression.[1]

Function

Knockdown of MELTF-AS1 inhibits osteosarcoma cell migration, invasion and proliferation. However,knockdown of MELTF-AS1 promotes osteosarcoma cell apoptosis in vitro.[1]

Labs working on this lncRNA

  • Department of Orthopaedic Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, P.R. China.
  • Department of Anatomy, Guangzhou Medical University, Guangzhou, Guangdong 510182, P.R. China.

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Yin, Z., et al., Overexpression of long non-coding RNA MFI2 promotes cell proliferation and suppresses apoptosis in human osteosarcoma. Oncol Rep, 2016. 36(4): p. 2033-40.