MYOSLID

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Annotated Information

Approved Symbol

MYOSLID ("myocardin-induced smooth muscle lncRNA, inducer of differentiation")

Chromosome

2q33.3

RefSeq(supplied by NCBI)

XR_923811

(A, C) or cultured Venous SMCs (B) were serum starved for 24 hrs, cells were then treated with the indicated growth factors for another 24 hrs before RNA isolation for qRT-PCR analysis[1]

Characteristics

MYOSLID is located in a lncRNA-rich genomic region of chromosome 2 where the closest protein coding genes are 70 kb (KLF7) and 200 kb (CREB1) away from its 5’end and 3’ end, respectively.[1] It is a VSMC-selective lncRNA, which is a direct transcriptional target of MYOCD/SRF and TGFβ/SMAD pathways.[1] MYOSLID transcripts are predominately localized in the cytosol.[1]

Regulation

MYOSLID is a new member of the SRF-dependent program of human VSMC differentiation and it can be directly targeted by MYOCD/SRF.Under pathological conditions, MYOSLID is reduced.[1]

Function

MYOSLID promotes F-actin assembly leading to MKL1 nuclear translocation and the subsequent transcriptional activation of downstream VSMC contractile genes.[1]

Labs working on this lncRNA

  • From the Department of Molecular and Cellular Physiology (J.Z., W.Z., W.W., E.T., M.X., A.R., D.J., H.A.S., X.L.), Albany Medical College, NY; Department of Medicine, Jersey Shore University Medical Center, Neptune, NJ (A.A.); Departments of Genetics (M.L., D.Z.) and Neurology and Neuroscience (D.Z.), Albert Einstein College of Medicine, Bronx, NY; Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, NY (P.J., J.M.M.); and National Aquafeed Safety Assessment Center, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing, P.R. China (M.X.).[1]
  • From the Department of Molecular and Cellular Physiology (J.Z., W.Z., W.W., E.T., M.X., A.R., D.J., H.A.S., X.L.), Albany Medical College, NY; Department of Medicine, Jersey Shore University Medical Center, Neptune, NJ (A.A.); Departments of Genetics (M.L., D.Z.) and Neurology and Neuroscience (D.Z.), Albert Einstein College of Medicine, Bronx, NY; Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, NY (P.J., J.M.M.); and National Aquafeed Safety Assessment Center, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing, P.R. China (M.X.). longx@mail.amc.edu.[1]

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Zhao, J., et al., MYOSLID Is a Novel Serum Response Factor-Dependent Long Noncoding RNA That Amplifies the Vascular Smooth Muscle Differentiation Program. Arterioscler Thromb Vasc Biol, 2016. 36(10): p. 2088-99.
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