TH2LCRR
TH2LCRR, which is located at 3' end of the RAD50 gene, the location of TH2-LCR(locus control region) in mice, selectively expressed in primary and effector TH2 cultures relative to primary and effector TH1 and TH17 cultures and functions by binding hnRNPs and WDR5.
Contents
Annotated Information
Name
TH2LCRR: T helper type 2 locus control region associated RNA (HGNC nomenclature)
TH2-LCR [1]
Characteristics
It is located at 3’ end of the RAD50 gene, the location of TH2-LCR(locus control region) in mice [1].
Cellular Localization
TH2LCR transcript was enriched in the nuclear fraction[1].
Function
In murine T cells, the TH2LCR is necessary to establish hisone H3K4Me marks at Il4, Il3 and Il5 promoters and distal DNA regulatory elements surrounding these genes[1].
TH2LCR facilitates the formation of H3KRMe3 marks at multiple genomic positions at IL4 and IL13 loci[1].
TH2LCR lncRNAs recruit WDR5-containing complexes to regulatory genomic elements(IL4 promoter, IL4 intron and IL4 distal sequence along with the IL13 promoter and two IL13 distal regulatory elements). [1].
Diseases
- allergic asthma[1]
Expression
It is selectively expressed in primary and effector TH2 cultures relative to primary and effector TH1 and TH17 cultures[1].
It was co-expressed with IL4, IL5, IL13 genes, it is located within RAD50 but was not co-expressed with RAD50[1].
Sequence
>gi|827839360|ref|NR_132124.1| Homo sapiens T helper type 2 locus control region associated RNA (TH2LCRR), transcript variant 1, long non-coding RNA
000081 TACCTGCCTT TTGTCCAGCA CTGCATCGTC CTCGCATATC CAAGGCTGTG TCTCCCTTCA GCATCACCAC TCGGCTTTTA 000160
000161 GCAGACTGAA GCCATGGTTT TTAGTTTTGT CTCTAGTGAT GAGCAGAAAA GAGGGATGAG GAAGAGGCTT TACTGGTCCA 000240
000241 ACCAGAAAGA GAAGCTAAGA ACCCATGACT GGATTCTCTC CCTTGGACAC CCCACAGACC AATATCTCAC CTTCCAGGAG 000320
000321 AAGACCCTTC CAGCTCTTGC TTCTTTAAAC CTATTAACTT AGTTTTCTTT AGCTAGACTC CCAAACATCA GCTTTTACAA 000400
000401 TTCAGCCTAT GGTTCAATCA CTATGGCAAG ATAAACATTT GTTTAGGTGT GAAACAAAAA AAAAAAAAAA
Labs working on this lncRNA
- Department of Medicine, Vanderbilt University School of Medicine, Tennessee 37232, USA [1].
