TP53TG1
TP53TG1, a p53-induced lncRNA, plays a vital role in the progression of human cancers.
Contents
Annotated Information
Approved Symbol: TP53TG1
Approved Name: TP53 target 1 (non-protein coding)
Previous Symbols: TP53AP1
Synonyms: H_RG012D21.9, LINC00096
Chromosome：7q21.1
RefSeq ID：NR_015381
OMIM ID：616403
Ensembl ID: ENSG00000182165
LncBook ID: HSALNT0289272
Characteristics
TP53TG1 , a long intergenic non-protein-coding RNA with 751 nt in length, was revealed to exert a tumor-suppressor feature in human cancer [1].
Function
TP53TG1 expression levels in NSCLC tissues and cells.[2].
- It is reported that TP53TG1 under glucose deprivation might facilitate cell proliferation and migration by affecting the expression of glucose metabolism related genes in glioma[3].
- TP53TG1 increased the sensitivity of NSCLC cells to cisplatin by modulating miR-18a/PTEN axis, elucidating a novel approach to boost the effectiveness of chemotherapy for non-small cell lung cancer (NSCLC)[2].
Regulation
Diseases
Glioma[3].
Non-small cell lung cancer[2].
Expression
TP53TG1 level was downregulated in cell lung cancer (NSCLC) tissues and cell lines[2].
| Experiment | Sense primer | Antisense primer |
|---|---|---|
| Quantitative real-time PCR | 5'-ACGAAGGTACCCAACCCTCT- 3' | 5'-GGTGTAAGTGTTCGCCTGGT- 3'[2] |
Evolution
Sequence
>gi|168823573|ref|NR_015381.1| Homo sapiens TP53 target 1 (non-protein coding) (TP53TG1), long non-coding RNA
000001 CCCTGTCTCC AGTGGGCGTC TTGGGCCCCG GCTCTATTCT GGGCTGCGGG CCTGGGAAGG GCTCGCCGGG TGCCAAATGA 000080
000081 GCTGTCCTAA CTCTGCGGGG CTGCAGCTTC CTGCATGATG CTGGGGAGCT TGGCGCCTGA CCCAGGATCT AGAAGGCACT 000160
000161 CTGGGCAGGC CGCGCTCCGC CCACGAAGGT ACCCAACCCT CTGGGATAGA TGCAGGAAGC GATGGTTAAG ACCCATTTTC 000240
000241 ACCCAACTTC TCGCCGCAGG TCTGGCTTAC CACACGCTCC TCCCCATTCC CAGTGAGCCG CTTTTTGCAG CACCAGGCGA 000320
000321 ACACTTACAC CAGTGCTTTG TAAAGGAATC TTATTGTCCA CCCCGTGTCT TGGCAAAAGA ACAGTGATCA CACAGATTCC 000400
000401 TACTTGGGCT CTTTCCTTTA ATCTTCGGAG GCTGAGTTTG CCCAACTCAG GTTTAACCAC CAAGGACTCT GAGAGCTGGC 000480
000481 AGGTCTGAGT AACCCTGGTA ACAATTCTCT TCACCTTATC AAAACCTGAG CTAAAACCAA TGCATCAGCT GATGATGACA 000560
000561 GCAGAGAGTG GCAGGGCTGA GGACCCAAAG TCATTTCCCA GGCTGGCGGA GAATAAACTG CCAGGGAGAA GAATGAGAAG 000640
000641 ACAGGAGACA AACTGTTTGG AAAGCTAAAT CTTCCCTCTT AATGAATAAA GGTTTTTGCC TTGTCTTAAA AAAAAAAAAA 000720
000721 AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA A
000081 GCTGTCCTAA CTCTGCGGGG CTGCAGCTTC CTGCATGATG CTGGGGAGCT TGGCGCCTGA CCCAGGATCT AGAAGGCACT 000160
000161 CTGGGCAGGC CGCGCTCCGC CCACGAAGGT ACCCAACCCT CTGGGATAGA TGCAGGAAGC GATGGTTAAG ACCCATTTTC 000240
000241 ACCCAACTTC TCGCCGCAGG TCTGGCTTAC CACACGCTCC TCCCCATTCC CAGTGAGCCG CTTTTTGCAG CACCAGGCGA 000320
000321 ACACTTACAC CAGTGCTTTG TAAAGGAATC TTATTGTCCA CCCCGTGTCT TGGCAAAAGA ACAGTGATCA CACAGATTCC 000400
000401 TACTTGGGCT CTTTCCTTTA ATCTTCGGAG GCTGAGTTTG CCCAACTCAG GTTTAACCAC CAAGGACTCT GAGAGCTGGC 000480
000481 AGGTCTGAGT AACCCTGGTA ACAATTCTCT TCACCTTATC AAAACCTGAG CTAAAACCAA TGCATCAGCT GATGATGACA 000560
000561 GCAGAGAGTG GCAGGGCTGA GGACCCAAAG TCATTTCCCA GGCTGGCGGA GAATAAACTG CCAGGGAGAA GAATGAGAAG 000640
000641 ACAGGAGACA AACTGTTTGG AAAGCTAAAT CTTCCCTCTT AATGAATAAA GGTTTTTGCC TTGTCTTAAA AAAAAAAAAA 000720
000721 AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA A
Labs working on this lncRNA
- Department of Radiology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou 450052, China.
References
- ↑ Diaz-Lagares A, Crujeiras AB, Lopez-Serra P, Soler M, Setien F, Goyal A, et al. Epigenetic inactivation of the p53-induced long noncoding RNA TP53.
- ↑ 2.0 2.1 2.2 2.3 2.4 Xiao H, Liu Y, Liang P, Wang B, Tan H, Zhang Y, Gao X, Gao J. TP53TG1 enhances cisplatin sensitivity of non-small cell lung cancer cells through regulating miR-18a/PTEN axis. Cell Biosci. 2018 Mar 22;8:23.
- ↑ 3.0 3.1 Chen X, Gao Y, Li D, Hao B, Cao Y. LncRNA-TP53TG1 participated in the stress response under glucose deprivation in glioma. J Cell Biochem. 2017;118(12):4897–904
