CARMN
Contents
Annotated Information
Approved Symbol
CARMN
Approved Name
cardiac mesoderm enhancer-associated non-coding RNA
Previous Symbols
MIR143HG
Synonyms
CARMEN
Function
CARMEN is a crucial regulator of cardiac cell differentiation and homeostasis. CARMEN exhibits RNA-dependent enhancing activity and is upstream of the cardiac mesoderm-specifying gene regulatory network. Interestingly, CARMEN interacts with SUZ12 and EZH2, two components of the polycomb repressive complex 2 (PRC2). CARMEN is modulated in cardiac disease and required for maintaining a differentiated cardiac fate. Carmen was significantly upregulated post myocardial infarction, supporting a role for Carmen in adult heart homeostasis and cardiac remodeling.
Regulation
CARMEN is able to control cardiac specification and differentiation independently of MIR-143/145. CARMEN exhibits cis-acting function, and interacts with SUZ12 and EZH2
Disease
cardiac differentiation
Chromosome
5q32
RefSeq ID
NR_105059
OMIM ID
_
Ensembl ID
ENSG00000249669
Reference
- ↑ Ounzain, S. et al. CARMEN, a human super enhancer-associated long noncoding RNA controlling cardiac specification, differentiation and homeostasis. J Mol Cell Cardiol 89, 98-112, doi:10.1016/j.yjmcc.2015.09.016 (2015).
Sequence
>gi|563318940|ref|NR_105059.1| Homo sapiens cardiac mesoderm enhancer-associated non-coding RNA (CARMN), transcript variant 1, long non-coding RNA
000081 GCCAGCTGCT TAAAAATGCC CCTGTGGCAG CGAGGGGCAC CAGAGGCTGG GTCTAATTAG TTGAGAAGCA GTGACACCCC 000160
000161 CAACCACTCC CCAAACAGGC TGGCTCCCGT CTCCAGGCCC CAAGGAGCCA CACCTGGACC AGACCCCAGG AAAGACATGT 000240
000241 GGTGGAAACC CTACGGCCCT GGAGCCCAAG GAGAGCAACG GCTGTAACAA GTGCACAGGC AAGGGCGCTA GCTGGTGGGA 000320
000321 GCCACCCCGC CATGCTGATG TCAGAGAAGC AAGAACTCTG GAGAAGCAGC CTCCTGGGAC CAGAGGAGGG CCAGCAGCAG 000400
000401 GCAGCCCGGA GACAGAACTC TCACCCACGC CTCTCCAAGC CTCCCAACAG AAGACAGAGG TCCCCCACAG CCAGAGACAT 000480
000481 TTCCTGAAGA CATGGGGAAC ACAGAGGCAG AAACAGCCCA TCCACCCAGG AGCTGTCCCC CACACTGCCG GGAGCCGGCA 000560
000561 CCCAGAGCCG CCAGGTAAAA CTGAGGCCAC CTGGTTCAAC ATCACCTTTC ACAGAAGGGG AAGCAGCCAC AGAAAGAAGG 000640
000641 GCCTCGTTAA GAAGTGGAAC CTGGGACCCC CAAGCGGTGT CTCTCATCCT GACTGGGGAT CCAGAGTAGG AGGGAGCCTT 000720
000721 TGGTGGGGTT GGAGTCCCGC CACAGGCCAC CAGAGCGGAG CAGCGCAGCG CCCTGTCTCC CAGCCTGAGG TGCAGTGCTG 000800
000801 CATCTCTGGT CAGTTGGGAG TCTGAGATGA AGCACTGTAG CTCAGGAAGA GAGAAGTTGT TCTGCAGCCA TCAGCCTGGA 000880
000881 AGTGCCTGGC TGGTGGGCCT TCTTGCAGTA GCTTCCCCTG GAGAAGAGGA AAAGCAAACC TTCATTGAGA CCCAAGCGGT 000960
000961 CTCTCCTGTG CTCTGTGACA ATAATAAAGT TCCAGCCCTT GGCAAAAAAA AAA
