CT70

Annotated Information

Name

Approved symbol: CT70

Approved name: cancer/testis associated transcript 70

HGNC ID: HGNC:37195

Previous names: cancer/testis antigen 70

Alias symbols: LeXis

RefSeq ID: XR_001746866

Characteristics

Schematic representation of the LeXis gene locus((Sallam T 2016))

LeXis, named as "Liver-expressed LXR-induced sequence", it's gene locus Lie in close proximity to the canonical LXR target gene Abca1 in mouse((Sallam T 2016)), was distinct gene with Abca1, almost exclusively located in the insoluble nuclear pellet in fractionation studies, along with the known nuclear lncRNAs XIST and histone H3.

Expression

The highly expressed in primary mouse hepatocytes treated with GW3965((Sallam T 2016)) and upregulated in OS(Osteosarcoma) tissues((Wang G 2017)).

Regulation

Please input evolution information here.

Function

Model of hLarp7 recognition of the 7SK 3′end and mechanism of assembly of core 7SK RNP((Eichhorn 2018))

LeXis binds with heterogeneous ribonucleoprotein Raly which contains both an RNA-binding domain and a leucine-zipper coiled domain, to affect the expression of srebf2 gene, resulting to the change of the level of SREBP-2(sterol regulatory element-binding protein), to modulate cholesterol metabolism((Sallam T 2016)).

LeXis positively regulates CTNNB1 expression by functioning as a ceRNA against miR-199a to promote osteosarcoma growth((Wang G 2017)).

Disease

• osteosarcoma
• colon adenocarcinoma

Evolution

Please input evolution information here.

Labs working on this lncRNA

• No.4 Department of Orthopedics, Cangzhou Central HospitalCangzhou, Hebei Province, China
• Department of Pathology and Laboratory Medicine, Howard Hughes Medical Institute, University of California, Los Angeles, California 90095, USA.

References

Annotation originally sourced from lncRNAdb.

Basic Information

Transcript ID	NONHSAT113149
Source	NONCODE4.0
Same with	,
Classification	intergenic
Length	332 nt
Genomic location	chr6+:52860418..52860749
Exon number	1
Exons	52860418..52860749
Genome context
Sequence	000001 GGATGTGAGG GCGATCTGGC TGCGACATCT GTCACCCCAT TGATCGCCAG GGTTGATTCG GCTGATCTGG CTGGCTAGGC 000080 000081 GGGTGTCCCC TTCCTCCCTC ACCGCTCCAT GTGCGTCCCT CCCGAAGCTG CGCGCTCGGT CGAAGAGGAC GACCATCCCC 000160 000161 GATAGAGGAG GACCGGTCTT CGGTCAAGGG TATACGAGTA GCTGCGCTCC CCTGCTAGAA CCTCCAAACA AGCTCTCAAG 000240 000241 GTCCATTTGT AGGAGAACGT AGGGTAGTCA AGCTTCCAAG ACTCCAGACA CATCCAAATG AGGCGCTGCA TGTGGCAGTC 000320 000321 TGCCTTTCTT TT

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